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- Pharmacology For Thiocolchicoside + Ketoprofen
Thiocolchicoside + Ketoprofen Pharmacology
Thiocolchicoside + Ketoprofen
About Thiocolchicoside + KetoprofenN/AMechanism of Action of Thiocolchicoside + KetoprofenN/APharmacokinets of Thiocolchicoside + KetoprofenN/AOnset of Action for Thiocolchicoside + KetoprofenN/ADuration of Action for Thiocolchicoside + KetoprofenN/AHalf Life of Thiocolchicoside + KetoprofenN/ASide Effects of Thiocolchicoside + KetoprofenN/AContra-indications of Thiocolchicoside + KetoprofenN/ASpecial Precautions while taking Thiocolchicoside + KetoprofenN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Thiocolchicoside + Ketoprofen1.Degenerative vertebral disorders
2.Dorsal pain
3.Lowback pain
4.Torticollis
Interactions for Thiocolchicoside + KetoprofenN/ATypical Dosage for Thiocolchicoside + KetoprofenN/ASchedule of Thiocolchicoside + KetoprofenN/AStorage Requirements for Thiocolchicoside + KetoprofenN/AEffects of Missed Dosage of Thiocolchicoside + KetoprofenN/AEffects of Overdose of Thiocolchicoside + KetoprofenN/AThiocolchicoside
About ThiocolchicosideA GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant.Mechanism of Action of ThiocolchicosideThiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.Pharmacokinets of ThiocolchicosideN/AOnset of Action for ThiocolchicosideN/ADuration of Action for ThiocolchicosideN/AHalf Life of ThiocolchicosideN/ASide Effects of Thiocolchicoside1. Diarrhoea
2. Gastralgia
3. Nausea
4. Vomiting
5. Drowsiness
6. Anaphylactic reaction
Contra-indications of Thiocolchicoside1. Contraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Thiocolchicoside1. Use with caution in patients with diarrheaPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for ThiocolchicosidePainful muscle spasm associated with
1. Degenerative vertebral disorders
2. Torticollis
3. Dorsal pain
4. Low back pain
5. Traumatological disorders
6. Neurological disorders
Interactions for ThiocolchicosideNo known interactions with other drugs.Typical Dosage for ThiocolchicosideAdult-
Oral- 4mg twice a day for 5 to 7 days.
Intramuscular-
4mg twice a day for 3 to 5 days.
Schedule of ThiocolchicosideN/AStorage Requirements for ThiocolchicosideN/AEffects of Missed Dosage of ThiocolchicosideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ThiocolchicosideGive symptomatic and supportive treatment.Ketoprofen
About KetoprofenNSAID, propionic acid derivative, Analgesic,antipyretic,antiinflammatory.Mechanism of Action of KetoprofenIt inhibits cyclo oxygenase enzymes both COX1 and COX2.These cyclooxygenase enzyme catalyses the synthesis of prostaglandins from arachidonic acid in the tissue. These inhibition produces its analgesic, antipyretic and anti inflammatory effects. It can also stabilize the lysosomal membrane. It is a Non Steroidal Anti Inflammatory Drug. It is a propionic acid derivative.Pharmacokinets of KetoprofenAbsorption-Well absorbed orally. It enters to the synovial fluid and cross the placenta and blood brain barrier.
Distribution-Widely distributed in the body.99% of it bound to the plasma protein.
Metabolism - By hydroxylation and glucoronide conjugation in liver.
Excretion-It is excreted through urine and bile.
Onset of Action for KetoprofenOral - 1-2 hours
intramuscular - 1-2 hoursDuration of Action for KetoprofenOral - 6 to 8 hours
intramuscular - 3-4 hours
Half Life of Ketoprofen2 - 2.5 hoursSide Effects of Ketoprofen1. Nausea
2. Vomiting
3. Dyspepsia
4. Thrombocytopenia
5. Exfoliate dermatitis
6. Headache
7. Dizziness
8. CNS excitation
9. Depression
10.Peptic ulcer
11. BronchospasmContra-indications of Ketoprofen1. Hypersensitivity to Ketoprofen and other Non Steroidal Anti Inflammatory Drugs
2. Patients with history of peptic ulcer and dyspepsia
Special Precautions while taking Ketoprofen1.Hypertension
2.Oedema
3.Heart failure
4.Hepatic impairment
5.Renal impairment
6.AsthmaPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Ketoprofen1. Rheumatoid arthritis
2. Osteo arthritis
3. Pain due to dysmenorrhea
4. Treatment for exacerbations of musculo skeletal, periarticular and soft tissue disorders
5. Migraine
6. Gout-Acute attack
Interactions for KetoprofenNULL.Typical Dosage for KetoprofenOral-
In adults 100-200mg tab for rheumatoid disorder; 25-60mg every 6-8 hrs for pain.
In intramuscular injection it is 50-100mg every 4 hrs.
Schedule of KetoprofenHStorage Requirements for KetoprofenStore at room temperature.Effects of Missed Dosage of KetoprofenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of KetoprofenInduce emesis, and needs lavage with sodium bicarbonate followed by activated charcoal and cathartic. Supportive measures will be needed.Home Delivery for Thiocolchicoside + Ketoprofen in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including thiocolchicoside + ketoprofen.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for thiocolchicoside + ketoprofen and other medicines and health products. Home delivery services for thiocolchicoside + ketoprofen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take thiocolchicoside + ketoprofen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for thiocolchicoside + ketoprofen before they complete the sale. You can get this information while placing the order for thiocolchicoside + ketoprofen with the pharmacy.
Thiocolchicoside + Ketoprofen is a generic medicine name and there are several brands available for it. Some of the brands for thiocolchicoside + ketoprofen might be better known than thiocolchicoside + ketoprofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have thiocolchicoside + ketoprofen in stock, you can ask for one of the branded alternatives for thiocolchicoside + ketoprofen.
