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- Pharmacology For Folic acid + Mecobalamine + Amino acids
Folic acid + Mecobalamine + Amino acids Pharmacology
Folic acid + Mecobalamine + Amino acidsAbout Folic acid + Mecobalamine + Amino acidsN/AMechanism of Action of Folic acid + Mecobalamine + Amino acidsN/APharmacokinets of Folic acid + Mecobalamine + Amino acidsN/AOnset of Action for Folic acid + Mecobalamine + Amino acidsN/ADuration of Action for Folic acid + Mecobalamine + Amino acidsN/AHalf Life of Folic acid + Mecobalamine + Amino acidsN/ASide Effects of Folic acid + Mecobalamine + Amino acidsN/AContra-indications of Folic acid + Mecobalamine + Amino acidsN/ASpecial Precautions while taking Folic acid + Mecobalamine + Amino acidsN/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Folic acid + Mecobalamine + Amino acidsN/AInteractions for Folic acid + Mecobalamine + Amino acidsN/ATypical Dosage for Folic acid + Mecobalamine + Amino acidsN/ASchedule of Folic acid + Mecobalamine + Amino acidsN/AStorage Requirements for Folic acid + Mecobalamine + Amino acidsN/AEffects of Missed Dosage of Folic acid + Mecobalamine + Amino acidsN/AEffects of Overdose of Folic acid + Mecobalamine + Amino acidsN/A
Folic AcidAbout Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.About N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/A
Amino acidsAbout Amino acidsAn amino acid is any molecule that contains both amine and carboxyl functional groups. These amino acids are the basic components of proteins. There are twenty standard amino acids used by cells in protein biosynthesis that are specified by the general genetic code.
Amino acids are joined to each other by peptide bonds. A peptide bond is a chemical bond formed between two molecules (carboxyl group of one molecule reacts with the amino group of the other molecule), releasing a molecule of water (H2O). The resulting CO-NH bond is called a peptide bond, the chemical bond that links the amino acid monomers in a protein chain. Each protein has its own unique amino acid sequence that is known as its primary structure. Amino acids can be linked together in varying sequences to form a huge variety of proteins. The unique shape of each protein determines its function in the body.
Aminoacids are of 2 types, essential and nonessential. Essential amino acids are the ones that must be obtained in the diet and non-essential are synthesized within the body
Essential aminoacids: Methionine, Threonine, Tryptophan, Valine, Isoleucine, Leucine, Lysine, Phenylalanine, Histidine,
Nonessential aminoacids: Alanine, Asparagine, Aspartic acids, Proline, Glutamic acid, Glutamine, Serine
Amino acids Arginine, Cysteine, Glycine and Tyrosine are considered conditionally essential, meaning they are not normally required in the diet, but must be supplied exogenously to specific populations that do not synthesize it in adequate amounts
Histidine and Arginine are generally only considered essential in children, because the metabolic pathways that synthesize these amino acids are not fully developed in children.
Nutritional role of aminoacids: Aminoacids have been used orally or in relatively dilute solutions intravenously as supplementary nutrients for patients unable to metabolize intact protein adequately. For patients in whom oral or tube feeding is contraindicated or Inadequate good nutrition may be achieved or maintained by intravenous feeding known as total parenteral nutrition or intravenous or parenteral hyperalimentation. Such feeding provides essential nutrients in a sufficiently concentrated form that does not exceed normal daily fluid requirements.
Mechanism of Action of Amino acidsN/APharmacokinets of Amino acidsN/AOnset of Action for Amino acidsN/ADuration of Action for Amino acidsN/AHalf Life of Amino acidsN/ASide Effects of Amino acidsN/AContra-indications of Amino acidsN/ASpecial Precautions while taking Amino acidsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Amino acids1.Hypoproteinaemia
2.Pre and post surgeryInteractions for Amino acidsN/ATypical Dosage for Amino acidsN/ASchedule of Amino acidsN/AStorage Requirements for Amino acidsN/AEffects of Missed Dosage of Amino acidsN/AEffects of Overdose of Amino acidsN/A
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