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- Pharmacology For L-Arginine + Zinc + Folic Acid
L-Arginine + Zinc + Folic Acid Pharmacology
L-Arginine + Zinc + Folic AcidAbout L-Arginine + Zinc + Folic AcidN/AMechanism of Action of L-Arginine + Zinc + Folic AcidL-Arginine - The precursor of nitric oxide, induces slow and prolonged relaxation of Corpus cavernosum.
Zinc - Vital trace mineral for optimal foetal growth, Promotes testosterone synthesis
Folic Acid - Essential vitamin for cell division,Minimises intra-cavernosal oxidative stress
Pharmacokinets of L-Arginine + Zinc + Folic AcidN/AOnset of Action for L-Arginine + Zinc + Folic AcidN/ADuration of Action for L-Arginine + Zinc + Folic AcidN/AHalf Life of L-Arginine + Zinc + Folic AcidN/ASide Effects of L-Arginine + Zinc + Folic AcidN/AContra-indications of L-Arginine + Zinc + Folic AcidN/ASpecial Precautions while taking L-Arginine + Zinc + Folic AcidN/APregnancy Related InformationUse with cautionOld Age Related InformationMaty be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for L-Arginine + Zinc + Folic Acid1.Male reproductive improvement
Interactions for L-Arginine + Zinc + Folic AcidN/ATypical Dosage for L-Arginine + Zinc + Folic AcidN/ASchedule of L-Arginine + Zinc + Folic AcidN/AStorage Requirements for L-Arginine + Zinc + Folic AcidN/AEffects of Missed Dosage of L-Arginine + Zinc + Folic AcidN/AEffects of Overdose of L-Arginine + Zinc + Folic AcidN/A
L-ArginineAbout L-ArginineProteinogenic , a-amino acid, Essential amino acid.Mechanism of Action of L-ArginineL-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body.Pharmacokinets of L-ArginineN/AOnset of Action for L-ArginineN/ADuration of Action for L-ArginineN/AHalf Life of L-ArginineN/ASide Effects of L-Arginine1.Abdominal pain
8.Worsening of asthma
9.Low blood pressure.
Contra-indications of L-ArginineN/ASpecial Precautions while taking L-Arginine1.Allergies or asthma: L-arginine can cause an allergic response or make swelling in the airways worse. If you decide to take L-arginine, use it with caution.
2.Herpes: There is a concern that L-arginine might make herpes worse. There is some evidence that L-arginine is needed for the herpes virus to multiply.
3.Low blood pressure: L-arginine might lower blood pressure. This could be a problem if you already have low blood pressure.
4.Recent heart attack: There is a concern that L-arginine might increase the risk of death after a heart attack, especially in older people. If you have had a heart attack recently, don?t take L-arginine.
5.Surgery: L-arginine might affect blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop taking L-arginine at least 2 weeks before a scheduled surgery.
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for L-Arginine1.Angina
3.Congestive Heart Failure
Interactions for L-Arginine1.L-arginine seems to decrease blood pressure. Taking L-arginine along with medications for high blood pressure might cause your blood pressure to go too low.
2.Medications that increase blood flow to the heart (Nitrates) interacts with L-ARGININE
3.Sildenafil (Viagra) can lower blood pressure. L-arginine can also lower blood pressure
Typical Dosage for L-Arginine1.For congestive heart failure: doses range from 6-20 grams per day, as three divided doses.
2.For chest pain associated with coronary artery disease (angina pectoris): 3-6 grams three times per day for up to one month.
3.For preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease (angina pectoris): 700 mg four times daily.
4.For organic erectile dysfunction (ED): 5 grams per day. Taking lower doses might not be effective.
5.For preventing inflammation of the digestive tract in premature infants: 261 mg/kg added to oral feedings daily for the first 28 days of life.
Schedule of L-ArginineN/AStorage Requirements for L-ArginineN/AEffects of Missed Dosage of L-ArginineN/AEffects of Overdose of L-ArginineN/A
ZincAbout ZincTrance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.Mechanism of Action of ZincZinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.Pharmacokinets of ZincAbsorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.Onset of Action for ZincN/ADuration of Action for ZincN/AHalf Life of ZincN/ASide Effects of Zinc1. Nausea
3. Abdominal distress
4. Gastric ulceration
Contra-indications of ZincN/ASpecial Precautions while taking Zinc1.Don`t exceed prescribed dose
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
Interactions for ZincFluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.
Typical Dosage for ZincAdults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of ZincN/AStorage Requirements for ZincStore at a temperature below 30 degree CEffects of Missed Dosage of ZincTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ZincProvide symptomatic treatment and supportive measures
Folic AcidAbout Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.
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