- Medicine India
- Generic Medicines
- C
- Pharmacology For Cetirizine + Diethylcarbamazine
Cetirizine + Diethylcarbamazine Pharmacology
Cetirizine + Diethylcarbamazine
About Cetirizine + DiethylcarbamazineN/AMechanism of Action of Cetirizine + DiethylcarbamazineN/APharmacokinets of Cetirizine + DiethylcarbamazineN/AOnset of Action for Cetirizine + DiethylcarbamazineN/ADuration of Action for Cetirizine + DiethylcarbamazineN/AHalf Life of Cetirizine + DiethylcarbamazineN/ASide Effects of Cetirizine + DiethylcarbamazineN/AContra-indications of Cetirizine + DiethylcarbamazineN/ASpecial Precautions while taking Cetirizine + DiethylcarbamazineN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Cetirizine + DiethylcarbamazineParasitic infectionsInteractions for Cetirizine + DiethylcarbamazineN/ATypical Dosage for Cetirizine + DiethylcarbamazineN/ASchedule of Cetirizine + DiethylcarbamazineN/AStorage Requirements for Cetirizine + DiethylcarbamazineN/AEffects of Missed Dosage of Cetirizine + DiethylcarbamazineN/AEffects of Overdose of Cetirizine + DiethylcarbamazineN/ACetirizine
About CetirizineSecond Generation H1 Antagonist, Metabolite of hydroxyzine, Antihistamine.Mechanism of Action of CetirizineThis drug is a selective peripheral H1 receptor antagonist. Thus it inhibits the allergic symptoms produced by histamines like cold, rhinorrhea, sneezing, urticaria etc. The drug has some mast cell stabilizing properties. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.Pharmacokinets of CetirizineAbsorption- Well absorbed after oral administration
Distribution-Widely distributed in the body. 93% bound to the plasma proteins. It enters to the CNS in small amounts.
Metabolism-Metabolized in the liver to its metabolites by oxidative O-dealkylation
Excretion- Excreted through urine (50% as unchanged form) and a small amount through feces
Onset of Action for Cetirizine10-30 minDuration of Action for Cetirizine12-24hrsHalf Life of CetirizineIts plasma half life is 8.3 hrsSide Effects of Cetirizine1. Somnolence.
2. Fatigue
3. Malaise
4. Headache
5. Dry mouth
6. CNS stimulation in children
7. Dizziness
8. Tinnitus
9. Incordination
10. Blurred vision
12. Diplopia
13. Euphoria
14. Nervousness
15. Drowsiness
16. Excessive tiredness
17. Vomiting
18. Diarrhea
19. Sore throat
20. Stomach pain
Contra-indications of CetirizineHypersensitivity to the drug or hydroxyzine.Special Precautions while taking Cetirizine1. Renal impairment.
2. Hepatic dysfunction.
3. Haemodialysis.
4. Any work which require mental alertness like driving or machine operation.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Cetirizine1. Sneezing
2. Rhinorrhoea
3. Postnasal discharge.
4. Common coughs
5. Colds.
6. Chronic urticaria
7. Dermatitis
8. Pruritic skin disorders
9. Hay fever
10. Angioedema
Interactions for CetirizineAlcohol: Avoid excessive alcohol consumption.Typical Dosage for CetirizineOral-
Adult - 10 mg daily, single dose
Children (6-12 years) -5 mg daily.
Schedule of CetirizineN/AStorage Requirements for CetirizineStore in cool, dry, dark placeEffects of Missed Dosage of CetirizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CetirizineGive symptomatic and supportive treatment.Diethylcarbamazine
About DiethylcarbamazineAntiparasitic agents, Piperazines derivative, Antihelminthic agent, Filaricides.Mechanism of Action of DiethylcarbamazineThe drug exerts its action by altering micro filarial membrane which leads to their phagocytosis by tissue fixed monocytes of host. It also has an effect on muscular activity of micro filaria & adult worms causing hyperpolarisation and eventually they are dislodged.Pharmacokinets of DiethylcarbamazineAbsorption: It is absorbed orally.Distribution: Widely distributed.Metabolism: Metabolized by liver.
Excretion: Excreted through urine.
Onset of Action for Diethylcarbamazine1hourDuration of Action for Diethylcarbamazine12 hourHalf Life of Diethylcarbamazine4 to 12 hoursSide Effects of Diethylcarbamazine1. Anorexia
2. Nausea
3. Vomiting
4. Headache
5. Drowsiness
6. Myalgia
7. Arthralgia
8. Rashes
9. Fever
10. Tachycardia
11. Lymphadenopathy
Contra-indications of Diethylcarbamazine1. In Renal impairment
2. In Cardio vascular diseases
3. In debilitating individuals
4. In hypersensitivity to the drug
Special Precautions while taking Diethylcarbamazine1. Starts with a smaller dose & then increase to therapeutic dose for avoiding allergic manifestation
2. Use with caution in poor health individuals
3. Use with caution in renal diseases
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationNEONATES : ContraindicatedIndications for Diethylcarbamazine1. Filariasis
2. Filarial prophylaxis
3. Tropical eosinophilia
4. In larva migrans
Interactions for DiethylcarbamazineN/ATypical Dosage for DiethylcarbamazineStarts with 1mg/kg on first day. Then 2mg/kg 8hourly for 1 to 3 weeks
The course may be repeated after 6 months.
In larva migrans: 3mg/kg/day for 3 weeks
For prophylaxis:0.3g/week.
Schedule of DiethylcarbamazineHStorage Requirements for DiethylcarbamazineStore at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.Effects of Missed Dosage of DiethylcarbamazineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DiethylcarbamazineIn allergic manifestations due to the drug stops the drug and administer antihistaminics and glucocorticoids. Subsequent administration does not cause such reactions.Home Delivery for Cetirizine + Diethylcarbamazine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cetirizine + diethylcarbamazine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cetirizine + diethylcarbamazine and other medicines and health products. Home delivery services for cetirizine + diethylcarbamazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cetirizine + diethylcarbamazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cetirizine + diethylcarbamazine before they complete the sale. You can get this information while placing the order for cetirizine + diethylcarbamazine with the pharmacy.
Cetirizine + Diethylcarbamazine is a generic medicine name and there are several brands available for it. Some of the brands for cetirizine + diethylcarbamazine might be better known than cetirizine + diethylcarbamazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cetirizine + diethylcarbamazine in stock, you can ask for one of the branded alternatives for cetirizine + diethylcarbamazine.
