Ig G + Human Albumin Pharmacology
Ig G + Human Albumin
2. Fever (pyrexia)
4. Itching (pruritis)
5. Redness around injection site
6. Hardening of skin around injection site
7. Increased heart rate (tachycardia)
9. Pain and swelling at site of injection
2. Vaccination with a live vaccine (e.g. oral polio, MMR) at the same time or in the previous 3 weeks
3. Immunoglobulin A (IgA) deficiency
5. Coagulation disorder
2. Prevention of German measles following exposure in pregnancy
3. Prevention of Hepatitis A
4. Prevention of measles or reduction in measles symptoms following exposure in susceptible people 5. Reducing number and severity of infections in people with low levels of immunoglobulins in their blood
Long term protection:0.06 mL/kg bodyweight
Short term protection: 0.03 mL/kg bodyweight
For prophylaxis long term, the injections should be given 5 monthly but serological checks should be made to assess if active immunity has developed.
The following doses of Normal Immunoglobulin are recommended for persons who plan
to travel in areas where hepatitis A is common
Length of stay <3 months- 0.03 mL/kg bodyweight
3 months or longer - 0.06 mL/kg bodyweight (repeat every 4-6 months)
Institutional contacts- 0.06 mL/kg bodyweight. Staff in institutions where hepatitis is endemic- A large dose (0.06 mL/kg bodyweight)
should be given at the time of employment, and this should be repeated at six-monthly
intervals if the risk persists.
Measles- 0.2 mL/kg bodyweight for prevention.
Poliomyelitis- 0.3 mL/kg bodyweight.
Hypogammaglobulinaemia- 0.6 mL/kg bodyweight at intervals of one month. An additional dose should be given during the first month of treatment
2. Volume overload
3. Circulatory failure
3. In circulatory failure monitor central venous pressure
4. Renal impairment
2. Hypovolaemic shock
3. Normovolaemic haemodilution burns
4. Neonatal jaundice
Adults: 100 to 200ml.
Children: 1 to 2ml/kg body weight.
Burns: Initially 200 to 400ml; on 1st day followed by 100 to 200ml. or 2 to 4ml/kg body weight.
Neonatal jaundice: 10 to 15ml with exchange transfusion. Do not exceed 20 drops/minute.
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