S-Amlodipine + Metoprolol Pharmacology

S-Amlodipine + Metoprolol

About S-Amlodipine + Metoprolol
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Mechanism of Action of S-Amlodipine + Metoprolol
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Pharmacokinets of S-Amlodipine + Metoprolol
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Onset of Action for S-Amlodipine + Metoprolol
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Duration of Action for S-Amlodipine + Metoprolol
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Half Life of S-Amlodipine + Metoprolol
N/A
Side Effects of S-Amlodipine + Metoprolol
N/A
Contra-indications of S-Amlodipine + Metoprolol
N/A
Special Precautions while taking S-Amlodipine + Metoprolol
N/A
Pregnancy Related Information
Contraindicated; since Amlodipine and Metoprolol are contraindicated in pregnancy.So the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Amlodipine is contraindicated in lactation.
Children Related Information
N/A
Indications for S-Amlodipine + Metoprolol
It is a combination of calcium channel blocker Amlodipine and Beta blocker Metoprolol.
1.Hypertension
2.Arrhythmias
3.Angina
Interactions for S-Amlodipine + Metoprolol
N/A
Typical Dosage for S-Amlodipine + Metoprolol
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Schedule of S-Amlodipine + Metoprolol
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Storage Requirements for S-Amlodipine + Metoprolol
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Effects of Missed Dosage of S-Amlodipine + Metoprolol
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Effects of Overdose of S-Amlodipine + Metoprolol
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S-Amlodipine

About S-Amlodipine
Calcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.
Mechanism of Action of S-Amlodipine
S-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.
Pharmacokinets of S-Amlodipine
N/A
Onset of Action for S-Amlodipine
N/A
Duration of Action for S-Amlodipine
N/A
Half Life of S-Amlodipine
N/A
Side Effects of S-Amlodipine
1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm

Contra-indications of S-Amlodipine
1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment


Special Precautions while taking S-Amlodipine
Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for S-Amlodipine
Hypertension
Interactions for S-Amlodipine
N/A
Typical Dosage for S-Amlodipine
2.5mg once daily
Schedule of S-Amlodipine
H
Storage Requirements for S-Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of S-Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of S-Amlodipine
Give supportive measures and symptomatic treatment.

Metoprolol

About Metoprolol
A selective ?1 blocker, Anti-hypertensive.
Mechanism of Action of Metoprolol
Metoprolol is a cardio selective beta-1 adrenergic antagonist.
It have negative chronotropic and negative inotropic effects on heart. It decreases oxygen consumption; cardiac work and aortic pressure It decreases nor adrenaline and renin releases. It decreases central sympathetic out flow. In sympathetic over activity, it prolongs systole by retarding conduction. It increases oxygen supply and exercise tolerance in angina patients. The drug decreases BP in hypertensive individuals.
Antimigraine action: Metoprolol is useful in migraine due to its beta blockade action. Through beta blockade action it inhibits vasodilation and relieves migraine.
Pharmacokinets of Metoprolol
Absorption: well absorbed orally, bioavailabity is increased by administering along with food. Distribution: Widely distributed. Metabolism: Metabolized in liver by hydroxylation. Excretion: Excreted through urine.
Onset of Action for Metoprolol
15minutes
Duration of Action for Metoprolol
Up to 1 to12 hours
Half Life of Metoprolol
N/A
Side Effects of Metoprolol
1.Heart failure
2.Nightmares
3.Gastrointestinal problems
4.Nausea
5.Tiredness
6.Sinus bradycardia
7.Depression
8.Rash
9.Hypotension
10.Dizziness
11.Fatigue
12.Vomiting
13.Diarrhoea
14.Headache
15.Bronchospasm
Contra-indications of Metoprolol
1.Hypersensitivity to the drug
2.Second or third degree heart block
3.Congestive heart failure
4.Cardiogenic shock
5.Bradycardia
6.Bronchial asthma
7.Diabetes mellitus
Special Precautions while taking Metoprolol
1.Congestive heart failure
2.Hepatic impairment
3.The drug should be gradually withdraw with caution
4.Respiratory disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Contraindicated
Indications for Metoprolol
1.Hypertension
2.Arrhythmias
3.Angina
4.Migraine
5.Prophylaxis of myocardial infarction
6.Thyrotoxicosis
Interactions for Metoprolol
Thioamines: Increased efficacy of metoprolol.
Thyroid hormones: Decreased efficacy of metoprolol.
Benzodiazepines: Increased efficacy of benzodiazepines.
Clonidine: Abrupt withdrawal of clonidine may lead to hypertensive crisis.
Ergot alkaloids: Peripheral ischaemia, possible peripheral gangrene.
Lidocaine: Increased lidocaine level may occur leading to toxicity.
Prazosin: Increased postural hypotension produced by parzosin.
Sulphonylureas: Hypoglycaemic effects may be attenuated.
Typical Dosage for Metoprolol
Oral
Adult: 50 to 450mg/day
Hypertension: Starts with 50mg to 100mg/day once daily or in divided doses and gradually increases up to 450mg/day based on patient`s response
Arrhythmias:
Oral: 100mg to 150mg/day in 2 to 3 divided doses
I.V.: Dose range: 10 to 15mg. Starts with 5mg infused within 5minutes. Then repeat the therapy with the same dose at every 5minutes interval based on patient`s response
Maximum dose: 20mg
Angina: 50mg twice daily, gradually increases based on patient`s response at one week intervals
Maximum dose: 0.4gm/day
Migraine: 0.1 to 0.2gm/day in divided doses in 12th hourly to 6th hourly.
Prophylaxis of myocardial infarction: 0.1 to 0.2gm/day in divided doses
Myocardial infarction: 15mg in 3divided doses at 2minutes interval as I.V.bolus administration. Then 200mg orally in four divided doses for 2days.

Schedule of Metoprolol
H
Storage Requirements for Metoprolol
Store at controlled room temperature between 20 to 25 degree C in a well closed container

Effects of Missed Dosage of Metoprolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Metoprolol
Treatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal. Treat Bradycardia with atropine 0.5 to 1mg.If required administer isoproterinol with caution. Treat hypotension with glucagons and vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosides. Treat bronchospasm with isoproterinol and aminophylline

Home Delivery for S-Amlodipine + Metoprolol in Your City

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S-Amlodipine + Metoprolol is a generic medicine name and there are several brands available for it. Some of the brands for s-amlodipine + metoprolol might be better known than s-amlodipine + metoprolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-amlodipine + metoprolol in stock, you can ask for one of the branded alternatives for s-amlodipine + metoprolol.