Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium Pharmacology

Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium

About Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Mechanism of Action of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Pharmacokinets of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Onset of Action for Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Duration of Action for Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Half Life of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Side Effects of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Contra-indications of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Special Precautions while taking Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Pregnancy Related Information
Use with caution
Old Age Related Information
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Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
1.Cardiovascular diseases
2.Antioxidant
3.Diabetes
4.Mental disorders
Interactions for Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Typical Dosage for Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Schedule of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Storage Requirements for Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Effects of Missed Dosage of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Effects of Overdose of Alpha-Lipoic Acid + Eicosapentaenoic Acid + Docosahexenoic Acid + Selenium
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Alpha-Lipoic acid

About Alpha-Lipoic acid
Naturally occurring dithiol compound , antioxidant, Agent for neuropathies.
Mechanism of Action of Alpha-Lipoic acid
Alpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.
Pharmacokinets of Alpha-Lipoic acid
Absorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.
Onset of Action for Alpha-Lipoic acid
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Duration of Action for Alpha-Lipoic acid
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Half Life of Alpha-Lipoic acid
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Side Effects of Alpha-Lipoic acid
1.Nausea
2.Vomiting
Contra-indications of Alpha-Lipoic acid
1.Contraindicated during radiotherapy
Special Precautions while taking Alpha-Lipoic acid
Patient with diabetes and problems with glucose intolerance
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
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Indications for Alpha-Lipoic acid
1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disorders
Interactions for Alpha-Lipoic acid
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Typical Dosage for Alpha-Lipoic acid
Adult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.
Schedule of Alpha-Lipoic acid
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Storage Requirements for Alpha-Lipoic acid
Store at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.
Effects of Missed Dosage of Alpha-Lipoic acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.
Effects of Overdose of Alpha-Lipoic acid
Give supportive measures and symptomatic treatment.

Eicosapentaenoic Acid

About Eicosapentaenoic Acid
An omega-3 fatty acid, Essential fatty acid, dietary supplement, Anti atherosclerotic.
Mechanism of Action of Eicosapentaenoic Acid
Eicosapentaenoic acid is an omega-3 fatty acid. It is found with Docosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Eicosapentaenoic Acid
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Onset of Action for Eicosapentaenoic Acid
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Duration of Action for Eicosapentaenoic Acid
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Half Life of Eicosapentaenoic Acid
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Side Effects of Eicosapentaenoic Acid
1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.Diarrhoea
Contra-indications of Eicosapentaenoic Acid
Hypersensitivity to the drug
Special Precautions while taking Eicosapentaenoic Acid
1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Infants:Contraindicated
Indications for Eicosapentaenoic Acid
1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Eicosapentaenoic Acid
N/A
Typical Dosage for Eicosapentaenoic Acid
180mg once or twice daily
Schedule of Eicosapentaenoic Acid
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Storage Requirements for Eicosapentaenoic Acid
Store in airtight containers. Protect from light.
Effects of Missed Dosage of Eicosapentaenoic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Eicosapentaenoic Acid
Give supportive measures and symptomatic treatment.

Docosahexenoic Acid

About Docosahexenoic Acid
An omega-3 fatty acid(polyunsaturated fatty acids, PUFAs), An essential fatty acid, brain food ,Antiatherosclerotic.
Mechanism of Action of Docosahexenoic Acid
It is found with Eicosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Docosahexenoic Acid
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Onset of Action for Docosahexenoic Acid
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Duration of Action for Docosahexenoic Acid
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Half Life of Docosahexenoic Acid
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Side Effects of Docosahexenoic Acid
1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.Diarrhoea
8.Constipation
Contra-indications of Docosahexenoic Acid
Hypersensitivity to the drug
Special Precautions while taking Docosahexenoic Acid
1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Infants: Contraindicated
Indications for Docosahexenoic Acid
1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Docosahexenoic Acid
N/A
Typical Dosage for Docosahexenoic Acid
120 - 240 mg / day in single or 2 divided dose with Eicosapentaenoic acid.
Schedule of Docosahexenoic Acid
N/A
Storage Requirements for Docosahexenoic Acid
Store in airtight containers. Protect from light.
Effects of Missed Dosage of Docosahexenoic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Docosahexenoic Acid
Give supportive measures and symptomatic treatment.

Selenium

About Selenium
A vital antioxidant, selenium acts with vitamin E to protect the immune system and maintain healthy heart function. It is needed for pancreatic function and tissue elasticity and has been shown to protect against radiation and toxic minerals. High levels of heart disease are associated with selenium-deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China. Best sources are butter, Brazil nuts, seafood and grains grown in selenium-rich soil.
Mechanism of Action of Selenium
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Pharmacokinets of Selenium
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Onset of Action for Selenium
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Duration of Action for Selenium
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Half Life of Selenium
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Side Effects of Selenium
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Contra-indications of Selenium
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Special Precautions while taking Selenium
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Selenium
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Interactions for Selenium
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Typical Dosage for Selenium
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Schedule of Selenium
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Storage Requirements for Selenium
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Effects of Missed Dosage of Selenium
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Effects of Overdose of Selenium
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