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- Pharmacology For Mebeverine + Chlordiazepoxide
Mebeverine + Chlordiazepoxide Pharmacology
Mebeverine + Chlordiazepoxide
About Mebeverine + ChlordiazepoxideN/AMechanism of Action of Mebeverine + ChlordiazepoxideN/APharmacokinets of Mebeverine + ChlordiazepoxideN/AOnset of Action for Mebeverine + ChlordiazepoxideN/ADuration of Action for Mebeverine + ChlordiazepoxideN/AHalf Life of Mebeverine + ChlordiazepoxideN/ASide Effects of Mebeverine + ChlordiazepoxideN/AContra-indications of Mebeverine + ChlordiazepoxideN/ASpecial Precautions while taking Mebeverine + ChlordiazepoxideN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Mebeverine + Chlordiazepoxide1.Irritable bowel syndrome
2.GI tract spasm
Interactions for Mebeverine + ChlordiazepoxideN/ATypical Dosage for Mebeverine + ChlordiazepoxideN/ASchedule of Mebeverine + ChlordiazepoxideN/AStorage Requirements for Mebeverine + ChlordiazepoxideN/AEffects of Missed Dosage of Mebeverine + ChlordiazepoxideN/AEffects of Overdose of Mebeverine + ChlordiazepoxideN/AMebeverine
About MebeverineReserpine derivative, antimuscarinic, a musculotropic antispasmodic, Motility stimulant.Mechanism of Action of MebeverineMebeverine has a direct relaxant effect on smooth muscle. This will inhibits gastrointestinal propulsive motility and gastric acid secretion.Pharmacokinets of MebeverineAbsorption: It is well absorbed after oral administration.
Distribution:
Metabolism: Mebeverine is rapidly and extensively undergoes hydrolysis and forms Veratric acid
Excretion: Metabolites are excreted mainly in urine
Onset of Action for MebeverineN/ADuration of Action for MebeverineN/AHalf Life of Mebeverine1.1 hoursSide Effects of Mebeverine1.Gastrointestinal disturbances
2.Heart burn
3.Dizziness
4.Dyspepsia
Contra-indications of Mebeverine1.Hypersensitivity to MebeverineSpecial Precautions while taking Mebeverine1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Ischemic heart disease
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Mebeverine1.Irritable bowel syndromeInteractions for MebeverineN/ATypical Dosage for MebeverineAdult: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children above 10 years: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children below 10 years: contraindicated.
Schedule of MebeverineHStorage Requirements for MebeverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of MebeverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MebeverineGive supportive measures and symptomatic treatment.Chlordiazepoxide
About ChlordiazepoxideBenzodiazepine derivative, Sedative /hypnotic, Antianxiety and skeletal muscle relaxant.Mechanism of Action of ChlordiazepoxideChlordiazepoxide mainly acts on Limbic system and ascending reticular formation in the CNS. It binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will increase the concentration of inhibitory neurotransmitter GABA and chloride ions in the CNS and decreases firing rate of neurons. This in turn alters normal excitatory functions of the body.Pharmacokinets of ChlordiazepoxideAbsorption: It is absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It is metabolised to active metabolite in the liver. Excretion: Most metabolites are excreted through urineOnset of Action for Chlordiazepoxide1 - 2 hourDuration of Action for Chlordiazepoxide12 - 24 hourHalf Life of Chlordiazepoxide5 - 30 hourSide Effects of Chlordiazepoxide1.Ataxia
2.Drowsiness
3.Lethargy
4.Hallucination
5.Nausea
6.Constipation
7.Amnesia
8.Dependence
9.Pain at the site of injection
10.Confusion
11.Depression
12.Mood changesContra-indications of ChlordiazepoxideHypersensitivity to BenzodiazepinesSpecial Precautions while taking Chlordiazepoxide1.Renal impairment
2.Hepatic impairment
3.Myasthenia gravis
4.Respiratory disease
5.Jaundice
6.Use caution while driving vehicles, operating machines or other dangerous activitiesPregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with caution
children < 6 years: contraindicated
NEONATES- contraindicatedIndications for Chlordiazepoxide1. Anxiety
2.Treatment of alcohol withdrawal symptom
3. Insomnia
4. Pre and post operative apprehensionInteractions for ChlordiazepoxideAlcohol & Other CNS Depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol.
Valproic acid: Elimination of chlordiazepoxide decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa : Decrease in antiparkinsonism efficacy.
Morphine, Pethidine, Atropine and Magnesium trisilicate: Absorption of chlordiazepoxide is impaired.
Probenecid: May cause rapid onset or prolonged effect.
Rifampicin: Decreases efficacy.
Typical Dosage for ChlordiazepoxideAdults: 5 - 10 mg 3 - 4 times daily
Severe anxiety: 20 - 25 mg 3 - 4 times daily
Treatment of alcohol withdrawal symptom: 25 - 100 mg daily; Depending on the patient`s condition dose can be reduced after 2 - 3 weeks
Pre and post operative apprehension: 5 - 10 mg 3 - 4 times daily; the drug should be given one day before surgery in pre operative apprehension
Children: 5mg 3 - 4 times daily.Schedule of ChlordiazepoxideHStorage Requirements for ChlordiazepoxideStore at temperature 15 - 30 degree C.Protect from light and moisture. Keep out of the reach of children.Effects of Missed Dosage of ChlordiazepoxideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of ChlordiazepoxideGive support and symptomatic treatment. Induce emesis or gastric lavage has to be done followed by charcoal administration. Flumazenil can be given as antagonist.Home Delivery for Mebeverine + Chlordiazepoxide in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mebeverine + chlordiazepoxide and other medicines and health products. Home delivery services for mebeverine + chlordiazepoxide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take mebeverine + chlordiazepoxide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mebeverine + chlordiazepoxide before they complete the sale. You can get this information while placing the order for mebeverine + chlordiazepoxide with the pharmacy.
Mebeverine + Chlordiazepoxide is a generic medicine name and there are several brands available for it. Some of the brands for mebeverine + chlordiazepoxide might be better known than mebeverine + chlordiazepoxide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mebeverine + chlordiazepoxide in stock, you can ask for one of the branded alternatives for mebeverine + chlordiazepoxide.
