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- Pharmacology For Miglitol + Metformin
Miglitol + Metformin Pharmacology
Miglitol + MetforminAbout Miglitol + MetforminN/AMechanism of Action of Miglitol + MetforminN/APharmacokinets of Miglitol + MetforminN/AOnset of Action for Miglitol + MetforminN/ADuration of Action for Miglitol + MetforminN/AHalf Life of Miglitol + MetforminN/ASide Effects of Miglitol + MetforminN/AContra-indications of Miglitol + MetforminN/ASpecial Precautions while taking Miglitol + MetforminN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Miglitol + MetforminType 2 diabetes mellitusInteractions for Miglitol + MetforminN/ATypical Dosage for Miglitol + MetforminN/ASchedule of Miglitol + MetforminN/AStorage Requirements for Miglitol + MetforminN/AEffects of Missed Dosage of Miglitol + MetforminN/AEffects of Overdose of Miglitol + MetforminN/A
MiglitolAbout MiglitolAlpha-glucosidase inhibitor,Piperidine derivative, Oral anti-diabetic drug.Mechanism of Action of MiglitolThe drug exerts it`s antihyperglycaemic action by causing reversible competitive inhibition of membrane bound intestinal alpha-glucosidase hydrolase enzymes; which are the final enzymes in the carbohydrate digestion in the brush border of small intestinal mucosa. It also inhibits sucrase and weak inhibitory effects on pancreatic a-amylase and reduces digestion and absorption of polysaccharides and sucrose, lowers HbA1c, body weight and serum triglyceride levels. It delays and reduces glucose absorption and lowers postprandial hyperglycaemia.Pharmacokinets of MiglitolAbsorption: Absorption of drug is saturable at higher doses; a dose of 25mg is completely absorbed but at high dose of 100mg, only about 50 to 70% is absorbed, Distribution: It acts locally within the gastrointestinal tract; and distributed extracellularly, Metabolism: It is not metabolized in the body, Excretion: Excreted mainly through urine as unchanged drug.Onset of Action for MiglitolN/ADuration of Action for MiglitolN/AHalf Life of Miglitol2 hoursSide Effects of Miglitol1.Flatulence
5.Decreased serum iron
6.RashesContra-indications of Miglitol1.Hypersensitivity to the drug
4.Partial intestinal obstruction
5.Chronic intestinal diseases
6.Severe renal impairmentSpecial Precautions while taking Miglitol1.Mild to moderate renal impairment
2.Along with insulin or sulfonylureas
3.Enhance hypoglycaemic effects of sulfonylureas give glucose in such situations
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for MiglitolAs monotherapy as an adjunct to diet to improve glycemic control in patients with type 2 diabetes. Can be used in combination with sulphonylurea, metformin and/or insulin.Interactions for MiglitolNo serious drug interaction reported.Typical Dosage for MiglitolOral: 25mg thrice daily; start with the 1st bite of each main meal. Increased to 50mg thrice daily after 4 to 8 week. Then increased to 100mg thrice daily after 3 months if required based on the glycosylated haemoglobin level.
Schedule of MiglitolN/AStorage Requirements for MiglitolStore at controlled room temperature at a range of 15 to 30 degree C. in a well closed container. Protect from moisture. Keep out of reach of children.Effects of Missed Dosage of MiglitolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MiglitolProvide symptomatic treatment and supportive measures.
MetforminAbout MetforminBiguanide derivative, Oral anti-diabetic.Mechanism of Action of MetforminIt is a biguanide which exerts antidiabetic action. The drug suppresses gluconeogenesis in liver and thus suppresses hepatic glucose output. It enhance insulin mediated glucose disposal in muscle and adipose tissue. It enhance GLUT1 (glucose transporter-1) transport from intracellular site to plasma membrane. It also interferes with respiratory chain in mitochondria and promotes peripheral glucose utilization by increasing anaerobic glycolysis. It inhibits intestinal absorption of glucose, other hexose sugars, amino acids and vitamin B12. It also improves lipid profile in type-2 diabetics.Pharmacokinets of MetforminAbsorption: Absorbed orally and bioavailability is about 50% to60%. Distribution: It is distributed in to erythrocytes, Metabolism: Not metabolized in the body, Excretion: Excreted mainly through urine.Onset of Action for MetforminN/ADuration of Action for Metformin6 to 8 hoursHalf Life of Metformin1.5 to 3hoursSide Effects of Metformin1. Abdominal pain
5. Metalic taste
6. Mild diarrhea
8. Small increase in blood lactate
9. Lactic acidosis (rare)
10. Vitamin B12 deficiency
11. Megaloblastic anaemia
Contra-indications of Metformin1. Hypersensitivity to the drug
2. Renal impairment
3. Hepatic impairment
4. Diabetic ketoacidosis
5. Cardiovascular collapse
6. Hypotensive states
7. Respiratory disease
Special Precautions while taking Metformin1. Alcohol intake can precipitate severe lactic acidosis
2. Vitamin B12deficiency
3. In malnourished and deliberate individuals
4. Adrenal insufficiency
5. Pituitary insufficiency.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for MetforminNon-insulin dependent diabetes mellitus (as adjunct to diet and exercise).Interactions for MetforminN/ATypical Dosage for MetforminAdults: Initial dose: 250mg twice or thrice daily with meals. Increase gradually at 2 week intervals, if required to a maximum of 3g daily.
Children: Not applicable. Schedule of MetforminGStorage Requirements for MetforminStore at room temperature at a range of 15 to 30 degree C. in a well closed container.Keep out of reach of children.
Effects of Missed Dosage of MetforminTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of MetforminProvide supportive measures and symptomatic treatment. Remove accumulated drug from the body by haemodialysis.
Home Delivery for Miglitol + Metformin in Your City
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Miglitol + Metformin is a generic medicine name and there are several brands available for it. Some of the brands for miglitol + metformin might be better known than miglitol + metformin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have miglitol + metformin in stock, you can ask for one of the branded alternatives for miglitol + metformin.