- Medicine India
- Generic Medicines
- M
- Pharmacology For Minoxidil + Azelaic acid + Tretinoin
Minoxidil + Azelaic acid + Tretinoin Pharmacology
Minoxidil + Azelaic acid + Tretinoin
About Minoxidil + Azelaic acid + TretinoinN/AMechanism of Action of Minoxidil + Azelaic acid + TretinoinN/APharmacokinets of Minoxidil + Azelaic acid + TretinoinN/AOnset of Action for Minoxidil + Azelaic acid + TretinoinN/ADuration of Action for Minoxidil + Azelaic acid + TretinoinN/AHalf Life of Minoxidil + Azelaic acid + TretinoinN/ASide Effects of Minoxidil + Azelaic acid + TretinoinN/AContra-indications of Minoxidil + Azelaic acid + TretinoinN/ASpecial Precautions while taking Minoxidil + Azelaic acid + TretinoinN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Minoxidil + Azelaic acid + TretinoinBaldnessInteractions for Minoxidil + Azelaic acid + TretinoinN/ATypical Dosage for Minoxidil + Azelaic acid + TretinoinN/ASchedule of Minoxidil + Azelaic acid + TretinoinN/AStorage Requirements for Minoxidil + Azelaic acid + TretinoinN/AEffects of Missed Dosage of Minoxidil + Azelaic acid + TretinoinN/AEffects of Overdose of Minoxidil + Azelaic acid + TretinoinN/AMinoxidil
About MinoxidilA potassium channel agonist,Direct-Acting Vasodilator, Hair- growth stimulant,In androgenic alopecia.Mechanism of Action of MinoxidilMinoxidil works by activating PGHS 1 (prostaglandin endoperoxide synthase-1) which helps promote hair growth. It enhances follicular size and results in thicker hair shafts and stimulates and prolongs the anagen phase of the hair cycle. This will results in longer and increased number of hairs.Pharmacokinets of MinoxidilAbsorption: It is poorly absorbed after topical administrationOnset of Action for MinoxidilN/ADuration of Action for MinoxidilN/AHalf Life of MinoxidilN/ASide Effects of Minoxidil1.Headache
2.Dizziness
3.Irritation
4.Itch
5.Contact dermatitis
6.Palpitation
7.Irregular heart beat
8.Nausea
9.Vomiting
10.Diarrhoea
11.Dermatitis
12.Chest pain
13.Hypertension
14.HypotensionContra-indications of Minoxidil1.Hypersensitivity to MinoxidilSpecial Precautions while taking Minoxidil1.Renal impairment
2.Hepatic impairment
3.Cardiac impairment
4.Avoid contact with broken area, eye and mucus membranePregnancy Related InformationContraindicated.Old Age Related InformationUse with caution
above 65 years: contraindicatedBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
NEONATES: contraindicated
Indications for Minoxidil1. Alopecia areata
2. Androgenic alopeciaInteractions for MinoxidilN/ATypical Dosage for MinoxidilTopical
Adult: Apply 1 ml solution on the dry scalp and hair 2 times daily for 4 months or longer
Children: contraindicated
Schedule of MinoxidilN/AStorage Requirements for MinoxidilStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of MinoxidilApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MinoxidilGive supportive measures and symptomatic treatment. Thoroughly wash the hair. In accidental ingestion drug can be removed from the body by inducing emesis or gastric lavage. Absorption of the drug can be reduced by administration of activated charcoalAzelaic Acid
About Azelaic AcidAnti bacterial, Acne Product (Topical), AntiAcne,in rosacea treatment, a hair growth stimulant.Mechanism of Action of Azelaic AcidAzelaic acid is used in acne vulgaris due to its antimicrobial and an anti-keratinizing effect on the follicular epidermis. The antimicrobial effect is due to inhibition of synthesis of microbial cellular proteins. Azelaic acid possesses bacteriostatic and bactericidal (at high concentrations) properties against Staphylococcus epidermidis and Propionibacterium acnes which produce acne
By reducing the concentration of bacteria present on the skin, Azelaic acid decreases the inflammation associated0 with acne lesions. Azelaic acid also possesses a direct anti-inflammatory effect by scavenging oxygen radicals. The anti-keratinizing effects of Azelaic acid may be due to decreased synthesis of filaggrin (keratin filament aggregating protein). By inhibiting filaggrin, Azelaic acid normalizes the keratinization of the follicle and produces a reduction in non-inflamed acne lesions. Azelaic acid does not affect sebum excretion
The antiproliferative and cytotoxic actions of Azelaic acid may be due to reversible inhibition of a variety of oxido-reductive enzymes including DNA polymerase, tyrosinase, and mitochondrial enzymes of the respiratory chain. At the cellular level, Azelaic acid causes mitochondrial swelling and accumulation of cytoplasmic lipid droplets. Azelaic acid has shown efficacy in treating lentigo, cutaneous malignant melanoma, and melasma (chloasma). When Azelaic acid is applied topically in these conditions, there is a reduction in epidermal melanogenesis and replacement of abnormal melanocytes by normal cells; flattening of nodular areas may also occur. Hyperactive and malignant melanocytes are much more susceptible to the effects of Azelaic acid than are normal melanocytes.
Pharmacokinets of Azelaic AcidAbsorption: About 4 % of the applied medicament is absorbed in to the systemic circulation.Onset of Action for Azelaic AcidN/ADuration of Action for Azelaic AcidN/AHalf Life of Azelaic AcidN/ASide Effects of Azelaic Acid1.Local irritation
2.Burning
3.Pruritis
4.Stinging
5.Tingling
6.Itching
7.Redness
8.Dryness
9.Peeling
10.Warmth
Contra-indications of Azelaic Acid1. Hypersensitivity to Azelaic acidSpecial Precautions while taking Azelaic Acid1.Avoid contact with eyes mucous membrane
2.Stop the use of medicament if irritation occurs
3.Avoid use of Azelaic acid topical on dry chapped or irritated skin wounds or in Eczema
4.Avoid occlusive dressing
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution
NEONATES: contraindicated
Indications for Azelaic Acid1. Acne
2.Lentigo
3.Cutaneous malignant melanoma
4.Melasma (chloasma)
Interactions for Azelaic AcidN/ATypical Dosage for Azelaic AcidTopical: Azelaic acid 10 - 20 % is used. Clean and dry the face apply the medicament 1-2 times daily.Schedule of Azelaic AcidN/AStorage Requirements for Azelaic AcidStore at 15 - 30 degree C. Keep out the reach of children.Effects of Missed Dosage of Azelaic AcidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Azelaic AcidGive supportive measures and symptomatic treatmentTretinoin
About TretinoinRetinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.Mechanism of Action of TretinoinTretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reducedPharmacokinets of TretinoinAbsorption: Absorption after topical application is minimal.Onset of Action for TretinoinN/ADuration of Action for TretinoinN/AHalf Life of TretinoinN/ASide Effects of Tretinoin1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema
Contra-indications of Tretinoin1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn
Special Precautions while taking Tretinoin1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Tretinoin1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface
Interactions for TretinoinSulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.Typical Dosage for TretinoinTopical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.
Schedule of TretinoinHStorage Requirements for TretinoinStore at 15 - 25 degree C in a tightly closed container.Effects of Missed Dosage of TretinoinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TretinoinGive supportive measures and symptomatic treatment.Home Delivery for Minoxidil + Azelaic acid + Tretinoin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including minoxidil + azelaic acid + tretinoin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for minoxidil + azelaic acid + tretinoin and other medicines and health products. Home delivery services for minoxidil + azelaic acid + tretinoin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take minoxidil + azelaic acid + tretinoin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for minoxidil + azelaic acid + tretinoin before they complete the sale. You can get this information while placing the order for minoxidil + azelaic acid + tretinoin with the pharmacy.
Minoxidil + Azelaic acid + Tretinoin is a generic medicine name and there are several brands available for it. Some of the brands for minoxidil + azelaic acid + tretinoin might be better known than minoxidil + azelaic acid + tretinoin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have minoxidil + azelaic acid + tretinoin in stock, you can ask for one of the branded alternatives for minoxidil + azelaic acid + tretinoin.
