Cefazolin Pharmacology


About Cefazolin
First Generation cephalosporin antibiotic
Mechanism of Action of Cefazolin
Cefazolin is a 1st generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefazolin inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefazolin
Pharmacokinets of Cefazolin
Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed, Metabolism: Not metabolized, Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Onset of Action for Cefazolin
Within 1 hour
Duration of Action for Cefazolin
10 hours
Half Life of Cefazolin
Side Effects of Cefazolin
1.Pain after I.M. injection & thrombophlebitis after I.V. injection
3.Allergic manifestation
5.Pseudo membranous colitis
7.Elevated liver enzymes
Contra-indications of Cefazolin
1.Hpersensitivity to cephalosporins
2.Aong with other nephrotoxic drugs
3.Along with oral anticoagulants
4.Pseudo membranous colitis
Special Precautions while taking Cefazolin
1.Renal impairment
2.Patient allergic to penicillins
3.Neuromuscular disorders

Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
May be used.
Indications for Cefazolin
1.Respiratory tract infections
3.Surgical prophylaxis
5.Urinary tract &genital tract infections
6.Skin & soft tissue infections

Interactions for Cefazolin
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.
Oral anticoagulants: Hypoprothrombinaemic effect potentiated, bleeding complications may occur.
Bacteriostatic agents like Chloramphenicol: Decrease efficacy of Cefazolin.
Probenecid: Slows tubular excretion and this enhances efficacy.
Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefazolin.
Lab. test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb?s Test: False positive.
Urinary 17-Ketosteroid values: Falsely elevated values.

Typical Dosage for Cefazolin
Adults: 500mg to 1gm I.M. or I.V. three times daily or four times daily.
Maximum adult dose: Up to 12gm/day
Children: 25 to 50 mg/kg/day I.M or I.V. three times daily or four times daily.
Maximum child dose: 100mg/kg/day
Schedule of Cefazolin
Storage Requirements for Cefazolin
The constituted solution should be used within one day & stored and protected from light..
Effects of Missed Dosage of Cefazolin
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefazolin
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures

Home Delivery for Cefazolin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefazolin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefazolin and other medicines and health products. Home delivery services for cefazolin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefazolin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefazolin before they complete the sale. You can get this information while placing the order for cefazolin with the pharmacy.

Cefazolin is a generic medicine name and there are several brands available for it. Some of the brands for cefazolin might be better known than cefazolin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefazolin in stock, you can ask for one of the branded alternatives for cefazolin.