Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin Pharmacology

Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin

About Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Mechanism of Action of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
1.Aceclofenac relieves pain & inflammation.
2.Methyl Salicylate provides counter-irritant action.
3.Menthol enhances Aceclofenac absorption and provides cooling action.
4.Linseed oil helps in reducing inflammation.
5.Capsaicin provides counter-irritant action.
Pharmacokinets of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Onset of Action for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Duration of Action for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Half Life of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Side Effects of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Contra-indications of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Special Precautions while taking Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
1.Back pain
2.Knee pain
3.Sprain & strains
4.Soft tissue disorders
5.Osteoarthritis Knee
6.Spondylosis
7.Cervical spondylosis
8.Injury
9.Arthritis
10.Shoulder lesions
11.Frozen Shoulder
12.Prolapsed intervertebral disc
13.Thumb, knee, shoulder stiffness
14.Rheumatoid arthritis
15.Tennis elbow



Interactions for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Typical Dosage for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Schedule of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Storage Requirements for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Effects of Missed Dosage of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A
Effects of Overdose of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
N/A

Aceclofenac

About Aceclofenac
NSAID, Analgesic, Antiinflammatory, Anti arthritic.
Mechanism of Action of Aceclofenac
This drug has several mechanism of action.
1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action).
2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines.
3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production.
4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen.
5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs.
6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.
7. Aceclofenac is also an NSAID with greater COX-2 specificity
Pharmacokinets of Aceclofenac
Absorption- It is rapidly and completely absorbed after oral administration
Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma.
Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac
Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites
Onset of Action for Aceclofenac
N/A
Duration of Action for Aceclofenac
N/A
Half Life of Aceclofenac
The mean plasma elimination half-life is 4 - 4.3 hours
Side Effects of Aceclofenac
1. Dyspepsia
2. Abdominal pain
3. Dizziness
4. Vertigo
5. Pruritis
6. Rash
7. Dermatitis
8. Nausea
9. Diarrhoea
10. Flatulence
11. Gastritis
12. Constipation
13. Vomiting
14. Ulcerative stomatitis
15. Elevation of circulating levels of hepatic enzymes.
Contra-indications of Aceclofenac
1. Hypersensitivity to the drug
2. Bleeding from the stomach or intestines
3. Moderate to severely decreased kidney function
4. Hypersensitivity to other NSAIDs
5. Active peptic ulcer
Special Precautions while taking Aceclofenac
1. Hepatic porphyria
2. Bleeding tendencies
3. Blood disorders
4. Crohn`s disease
5. Decreased heart function
6. History of peptic ulcers
7. Inflammation of the bowel and back passage
8. Mildly decreased kidney function
9. Recent major surgery
10. Stomach disorders
11. Decreased liver function
12. Intestinal disorders
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
Indications for Aceclofenac
1. Ankylosing spondylitis
2. Osteoarthritis
3. Symptomatic treatment of pain and inflammation in Post-Traumatic pain
4. Cervical pain
5. Low back pain
6. Acute gout
Interactions for Aceclofenac
Lithium, digoxin and methotrexate: Aceclofenac may increase plasma concentrations of lithium, digoxin and methotrexate.
Anticoagulants: Activity of anticoagulants may be increased.
Diuretics : Aceclofenac inhibits the activity of diuretics. When concomitantly administrated with potassium sparing diuretics, serum potassium should be monitored.
Cyclosporin: Aceclofenac may enhance cyclosporin nephrotoxicity.
Quinolones : Aceclofenac may precipitate convulsions when coadministered with quinolone antibiotics.
Typical Dosage for Aceclofenac
Oral-
Adult (general dose)-
100mg twice daily
Schedule of Aceclofenac
H
Storage Requirements for Aceclofenac
Store below 25?C
Effects of Missed Dosage of Aceclofenac
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aceclofenac
Give symptomatic and supportive treatment. Induce gastric lavage and administer charcoal in repeated doses. Treated with antacid if necessary.

Methyl salicylate

About Methyl salicylate
Salicylates, Rubefacient, counterirritant.
Mechanism of Action of Methyl salicylate
Methyl salicylate is a rubefacient. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. It is also called as counterirritant because they produce their action by counter irritation. Irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.
Pharmacokinets of Methyl salicylate
N/A
Onset of Action for Methyl salicylate
N/A
Duration of Action for Methyl salicylate
N/A
Half Life of Methyl salicylate
N/A
Side Effects of Methyl salicylate
N/A
Contra-indications of Methyl salicylate
N/A
Special Precautions while taking Methyl salicylate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Methyl salicylate
N/A
Interactions for Methyl salicylate
N/A
Typical Dosage for Methyl salicylate
N/A
Schedule of Methyl salicylate
N/A
Storage Requirements for Methyl salicylate
N/A
Effects of Missed Dosage of Methyl salicylate
N/A
Effects of Overdose of Methyl salicylate
N/A

Menthol

About Menthol
Terpenes and terpenoid, Antipruritic, decongestant, topical analgesic.
Mechanism of Action of Menthol
Menthol acts as a local anesthetic on the respiratory passageways and causing cough suppression. When Menthol is rubbed on the skin, it acts as a rubefacient and causes localized vasodilatation; which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and mild local anaesthetic effect relieves itching. It has good soothing effect and acts as a demulcent. It also acts as a carminative.
Pharmacokinets of Menthol
N/A
Onset of Action for Menthol
N/A
Duration of Action for Menthol
N/A
Half Life of Menthol
N/A
Side Effects of Menthol
1.Irritation
2.Anxiety
3.Excitement
4.Delirium
5.Colic
6.Nausea
7.Vomiting
8.Diarrhoea
9.Convulsions
10.Apnoea
11.Asystole
12.Contact dermatitis
13.Allergic reactions
Contra-indications of Menthol
1. Hypersensitivity to the drug
2.Should not applies to broken, injured, or burned skin
Special Precautions while taking Menthol
1.Should not apply Menthol directly in to or near the nostrils of small children or asthma patients
2.Prolonged use
3.Seizures
4.Should not take steam inhalation orally
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
below 2 years: Contraindicated
Indications for Menthol
1. Rubefacient.
2.Ingredient in cough preparations
3.Antipruritic
4. Ingredient in ointment or liniment to treat sprains; joint and muscle pain
5.Sore throat
6.Cold sores
7.Hay fever
8.As an inhalant to relieve nasal, bronchial, or upper respiratory congestion
9.Sinusitis
10.Bronchial cough
11.Pharyngeal inflammation
Interactions for Menthol
N/A
Typical Dosage for Menthol
Dosage individualized based on requirements of the patient.
Lozenges: Dissolve lozenge (5%-10% menthol) slowly in the mouth hourly as needed by the patients.
Topical: Rubbed on the throat and chest in a layer loosely covered with a warm dry cloth; up to thrice daily.
In vaporizer: Menthol (3.2%) in a hot steam vaporizer can be used by adding 1 tbsp of solution for each quart of cold water, or 1tsp of solution for each pint, up to thrice daily
Schedule of Menthol
N/A
Storage Requirements for Menthol
Store at a cool dry place in a well closed container. Protect from light and heat. Keep out of reach of children.
Effects of Missed Dosage of Menthol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Menthol
Provide symptomatic treatment and supportive measures.

Linseed Oil

About Linseed Oil
It contains powerful, rare natural antioxidants (lignans), omega-3 fatty acids, vitamins and minerals. It is a popular oil in cosmetic manufacturing and to a lesser degree (but no less suitable), massage therapists and aroma therapists. Linseed oil is also well absorbed by the skin.
Mechanism of Action of Linseed Oil
N/A
Pharmacokinets of Linseed Oil
N/A
Onset of Action for Linseed Oil
N/A
Duration of Action for Linseed Oil
N/A
Half Life of Linseed Oil
N/A
Side Effects of Linseed Oil
N/A
Contra-indications of Linseed Oil
N/A
Special Precautions while taking Linseed Oil
Taking blood thinners may not be safe to use along with flaxseed oil as treatment for a medical condition. Flaxseed will make your blood thinning medication more effective, which could be dangerous.


Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Linseed Oil
1.Lower Cholesterol:Flaxseed oil and other sources of omega-3 fatty acids may increase your level of HDL--what is commonly called "good" cholesterol--and can help lower LDL ("bad" cholesterol) levels.
2.Healthy Heart:One of the elements in flaxseed oil, called alpha-linolenic acid (ALA), can lower your risk of heart disease through a number of factors. ALA keeps your blood vessels healthy, keeps platelets from sticking together and may even prevent minor arrhythmias.
3.Reduce Inflammation:The omega-3 found in flaxseed oil is a naturally-occurring anti-inflammatory agent. People who have arthritis, lupus, psoriasis and inflammatory bowel disorders may find a reduction in inflammation by adding flaxseed oil to their diets.
Interactions for Linseed Oil
N/A
Typical Dosage for Linseed Oil
Adults can safely take up to 2 tbsp. of flaxseed oil or two soft-gels daily for medical use. Check with your doctor before giving your child flaxseed oil.
Schedule of Linseed Oil
N/A
Storage Requirements for Linseed Oil
N/A
Effects of Missed Dosage of Linseed Oil
N/A
Effects of Overdose of Linseed Oil
N/A

Capsaicin

About Capsaicin
A lipophilic capsaicinoid(methyl vanillyl nonenamide),substance P release inducer, A topical analgesic ,antineuralgic and antipruritic, rubefacient.
Mechanism of Action of Capsaicin
Capsaicin is a rubefacient. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. It is also called as counterirritant because they produce their action by counter irritation. Irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.
Capsaicin depletes the neurochemical substance P which transmits pain and desensitizes person to pain. Capsaicin produces a temporary reduction in pain.
Pharmacokinets of Capsaicin
N/A
Onset of Action for Capsaicin
N/A
Duration of Action for Capsaicin
N/A
Half Life of Capsaicin
N/A
Side Effects of Capsaicin
1.Warm
2.Stinging
3.Burning
4.Skin redness
Contra-indications of Capsaicin
Hypersensitivity to Capsaicin
Special Precautions while taking Capsaicin
1.Wear gloves when applying cream.
2.Do not apply after a hot bath or shower or use it with a heating pad.
3.Avoid contact with eyes, mucus membranes or broken skin
4.Broken or irritated skin
5.Prolonged use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Below 2 years:Contraindicated
Indications for Capsaicin
1.Back pain
2.Bursitis
3.Fibromyalgia
4.Joint pain
5.Muscle pain
6.Nerve Pain
7.Osteoarthritis
8.Pain due to diabetic neuropathy
9.Post-herpetic neuralgia
10.Post-surgical neuropathic pain
Interactions for Capsaicin
N/A
Typical Dosage for Capsaicin
Topical
For neuralgia or itching of the skin:
Adults: Apply 0.025% cream 3 or 4 times a day and rub well and if sufficient response is not obtained apply 0.075% cream.
Children: Same as adult dose
Below 2 years: Contraindicated
Schedule of Capsaicin
N/A
Storage Requirements for Capsaicin
Store the medicine in a closed container at room temperature. Keep away from heat, moisture and direct light. Keep out of the reach of children.
Effects of Missed Dosage of Capsaicin
Apply the missed dose as soon as remember and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doses.
Effects of Overdose of Capsaicin
Give supportive measures and symptomatic treatment.

Home Delivery for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin in Your City

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Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin is a generic medicine name and there are several brands available for it. Some of the brands for aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin might be better known than aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin in stock, you can ask for one of the branded alternatives for aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin.