Betamethasone Dipropionate + Neomycin + Zinc Sulphate Pharmacology

Betamethasone Dipropionate + Neomycin + Zinc Sulphate

About Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Mechanism of Action of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Pharmacokinets of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Onset of Action for Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Duration of Action for Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Half Life of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Side Effects of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
1.Prolonged use may cause local atrophic changes in the skin e.g. thining, striae and dilatation of superficial blood vessels.
2.Local skin burning sensation, pruritus, pigmentation changes, allergic contact dermatitis and hypertrichosis.
Contra-indications of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
1.Hypersensitivity
2.Rosacea
3.Acne vulgaris
4.Perioral dermatitis
5.Perianal and genital pruritus
6.Primary cutaneous viral infections
7.Not to be used in otitis externa complicated by ear-drum perforation
8.Treatment of primary infected skin lesions caused by fungi or bacteria
9.Primary or secondary infections due to yeast; or secondary infections due to Pseudomonas or Proteus species.
Special Precautions while taking Betamethasone Dipropionate + Neomycin + Zinc Sulphate
1.Avoid prolonged treatment as it may lead to systemic corticosteroid effects even withour occlusion.
2.Avoid prolonged excessive application to the facial areas
3.Withdraw treatment if there is spread of the infection
4.Regular monitoring is recommended when used in psoriasis due to treatment tolerance, rebound relapses, generalised pustular psoriasis or systemic toxicity.
5.Increased risk of contact sensitisation when used for extended period or recurrently
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated below 2 years
Indications for Betamethasone Dipropionate + Neomycin + Zinc Sulphate
Corticosteriod-responsive dermatoses with secondary infection.
Interactions for Betamethasone Dipropionate + Neomycin + Zinc Sulphate
If there is significant systemic absorption, neomycin sulfate may increase the respiratory depressant effects of neuromuscular blockers.
Typical Dosage for Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Schedule of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Storage Requirements for Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Effects of Missed Dosage of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Effects of Overdose of Betamethasone Dipropionate + Neomycin + Zinc Sulphate
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Betamethasone dipropionate

About Betamethasone dipropionate
A synthetic glucocorticoid, anti-inflammatory.
Mechanism of Action of Betamethasone dipropionate
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone dipropionate
Absorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.

Onset of Action for Betamethasone dipropionate
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Duration of Action for Betamethasone dipropionate
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Half Life of Betamethasone dipropionate
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Side Effects of Betamethasone dipropionate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone dipropionate
1.Hypersensitivity to Betamethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone dipropionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Betamethasone dipropionate
1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Betamethasone dipropionate
N/A
Typical Dosage for Betamethasone dipropionate
Apply thinly 1 -2 times daily.
Schedule of Betamethasone dipropionate
H
Storage Requirements for Betamethasone dipropionate
Store at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Betamethasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Betamethasone dipropionate
Provide symptomatic treatment and supportive measures.

Neomycin

About Neomycin
An aminoglycoside, Antibiotic, Ammonium Detoxicant.
Mechanism of Action of Neomycin
This aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pharmacokinets of Neomycin
Absorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin
1 to 4 hr after oral administration
Duration of Action for Neomycin
8hrs after oral administration
Half Life of Neomycin
Its plasma half life is 2 to 3 hrs
Side Effects of Neomycin
1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin
1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin
1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Neomycin
1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for Neomycin
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Typical Dosage for Neomycin
Ophthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of Neomycin
C
Storage Requirements for Neomycin
Eye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.
Effects of Missed Dosage of Neomycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Neomycin
Give symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drug

Zinc Sulphate

About Zinc Sulphate
Zinc compound, An astringent , Adjunctive treatment of Wilson?s disease.
Mechanism of Action of Zinc Sulphate
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Pharmacokinets of Zinc Sulphate
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Onset of Action for Zinc Sulphate
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Duration of Action for Zinc Sulphate
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Half Life of Zinc Sulphate
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Side Effects of Zinc Sulphate
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Contra-indications of Zinc Sulphate
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Special Precautions while taking Zinc Sulphate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Zinc Sulphate
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Interactions for Zinc Sulphate
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Typical Dosage for Zinc Sulphate
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Schedule of Zinc Sulphate
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Storage Requirements for Zinc Sulphate
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Effects of Missed Dosage of Zinc Sulphate
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Effects of Overdose of Zinc Sulphate
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