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- Pharmacology For Mebeverine + Ispaghula Husk
Mebeverine + Ispaghula Husk Pharmacology
Mebeverine + Ispaghula Husk
About Mebeverine + Ispaghula HuskN/AMechanism of Action of Mebeverine + Ispaghula HuskN/APharmacokinets of Mebeverine + Ispaghula HuskN/AOnset of Action for Mebeverine + Ispaghula HuskN/ADuration of Action for Mebeverine + Ispaghula HuskN/AHalf Life of Mebeverine + Ispaghula HuskN/ASide Effects of Mebeverine + Ispaghula HuskN/AContra-indications of Mebeverine + Ispaghula HuskN/ASpecial Precautions while taking Mebeverine + Ispaghula HuskN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Mebeverine + Ispaghula HuskSymptomatic relief of irritable bowel syndrome.Interactions for Mebeverine + Ispaghula HuskN/ATypical Dosage for Mebeverine + Ispaghula HuskN/ASchedule of Mebeverine + Ispaghula HuskN/AStorage Requirements for Mebeverine + Ispaghula HuskN/AEffects of Missed Dosage of Mebeverine + Ispaghula HuskN/AEffects of Overdose of Mebeverine + Ispaghula HuskN/AMebeverine
About MebeverineReserpine derivative, antimuscarinic, a musculotropic antispasmodic, Motility stimulant.Mechanism of Action of MebeverineMebeverine has a direct relaxant effect on smooth muscle. This will inhibits gastrointestinal propulsive motility and gastric acid secretion.Pharmacokinets of MebeverineAbsorption: It is well absorbed after oral administration.
Distribution:
Metabolism: Mebeverine is rapidly and extensively undergoes hydrolysis and forms Veratric acid
Excretion: Metabolites are excreted mainly in urine
Onset of Action for MebeverineN/ADuration of Action for MebeverineN/AHalf Life of Mebeverine1.1 hoursSide Effects of Mebeverine1.Gastrointestinal disturbances
2.Heart burn
3.Dizziness
4.Dyspepsia
Contra-indications of Mebeverine1.Hypersensitivity to MebeverineSpecial Precautions while taking Mebeverine1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Ischemic heart disease
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Mebeverine1.Irritable bowel syndromeInteractions for MebeverineN/ATypical Dosage for MebeverineAdult: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children above 10 years: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children below 10 years: contraindicated.
Schedule of MebeverineHStorage Requirements for MebeverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of MebeverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MebeverineGive supportive measures and symptomatic treatment.Ispaghula Husk
About Ispaghula HuskBulk forming agent, LaxativeMechanism of Action of Ispaghula HuskAbsorbs water in the GI tract to form a mucilaginous mass which increases the volume of faeces and hence promotes peristalsisPharmacokinets of Ispaghula HuskAbsorption: Absorbed after oral administration
Metabolism: Metabolised in the colon
Onset of Action for Ispaghula HuskN/ADuration of Action for Ispaghula HuskN/AHalf Life of Ispaghula HuskN/ASide Effects of Ispaghula Husk1.Hypersensitivity reactions
2.Temporary increase of flatulence and abdominal distension
Contra-indications of Ispaghula Husk1.Intestinal obstruction
2.Colonic atony
Special Precautions while taking Ispaghula Husk1.Intestinal or oesophageal obstruction
2.Faecal impaction
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ispaghula Husk1.Constipation
2.Haemorrhoids
3.Mild to moderate hypercholesterolaemia
Interactions for Ispaghula HuskMay delay or reduce GI absorption of the cardiac glycosides, coumarin derivatives, lithium, vitamin (e.g. vitamin B12) and minerals (e.g. calcium, iron or zinc), carbamazepineTypical Dosage for Ispaghula HuskConstipation: 3.5 g, taken 1-3 times daily. To be taken immediately after mixing in 150 ml of water or fruit juice
Haemorrhoids: 3.5 g, taken 1-3 times daily. To be taken immediately after mixing in 150 ml of water or fruit juice
Mild to moderate hypercholesterolaemia: As an adjunct to lipid-lowering diet: 7 g daily
Schedule of Ispaghula HuskN/AStorage Requirements for Ispaghula HuskStore below 40 degree celcius in a well closed container. Protect from sunlight and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Ispaghula HuskN/AEffects of Overdose of Ispaghula HuskN/AHome Delivery for Mebeverine + Ispaghula Husk in Your City
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