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- Pharmacology For Minoxidil + Finasteride
Minoxidil + Finasteride Pharmacology
Minoxidil + Finasteride
About Minoxidil + FinasterideN/AMechanism of Action of Minoxidil + FinasterideN/APharmacokinets of Minoxidil + FinasterideN/AOnset of Action for Minoxidil + FinasterideN/ADuration of Action for Minoxidil + FinasterideN/AHalf Life of Minoxidil + FinasterideN/ASide Effects of Minoxidil + Finasteride1.Nausea or vomiting
2.Changes in skin or hair pigmentation
3.Tenderness in the breast area
4.Fragile or thin skin at the area of application
5.Itching or irritation at the point of application
Contra-indications of Minoxidil + FinasterideN/ASpecial Precautions while taking Minoxidil + FinasterideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Minoxidil + FinasterideHair loss treatment.Interactions for Minoxidil + FinasterideN/ATypical Dosage for Minoxidil + FinasterideSolution is applied in the mornings and/or evenings directly onto the area which is thinning or bald.
Before applying, ensure the scalp area is dry. Next, spread the solution evenly over the affected area(s). Finally, leave to allow to air dry without covering your scalp. Once completely dry, you are able to hair products, cover as you like, and lay down.
Always clean your hands using soap both before, and after applying Solution.
Schedule of Minoxidil + FinasterideN/AStorage Requirements for Minoxidil + FinasterideN/AEffects of Missed Dosage of Minoxidil + FinasterideN/AEffects of Overdose of Minoxidil + FinasterideN/AMinoxidil
About MinoxidilA potassium channel agonist,Direct-Acting Vasodilator, Hair- growth stimulant,In androgenic alopecia.Mechanism of Action of MinoxidilMinoxidil works by activating PGHS 1 (prostaglandin endoperoxide synthase-1) which helps promote hair growth. It enhances follicular size and results in thicker hair shafts and stimulates and prolongs the anagen phase of the hair cycle. This will results in longer and increased number of hairs.Pharmacokinets of MinoxidilAbsorption: It is poorly absorbed after topical administrationOnset of Action for MinoxidilN/ADuration of Action for MinoxidilN/AHalf Life of MinoxidilN/ASide Effects of Minoxidil1.Headache
2.Dizziness
3.Irritation
4.Itch
5.Contact dermatitis
6.Palpitation
7.Irregular heart beat
8.Nausea
9.Vomiting
10.Diarrhoea
11.Dermatitis
12.Chest pain
13.Hypertension
14.HypotensionContra-indications of Minoxidil1.Hypersensitivity to MinoxidilSpecial Precautions while taking Minoxidil1.Renal impairment
2.Hepatic impairment
3.Cardiac impairment
4.Avoid contact with broken area, eye and mucus membranePregnancy Related InformationContraindicated.Old Age Related InformationUse with caution
above 65 years: contraindicatedBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
NEONATES: contraindicated
Indications for Minoxidil1. Alopecia areata
2. Androgenic alopeciaInteractions for MinoxidilN/ATypical Dosage for MinoxidilTopical
Adult: Apply 1 ml solution on the dry scalp and hair 2 times daily for 4 months or longer
Children: contraindicated
Schedule of MinoxidilN/AStorage Requirements for MinoxidilStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of MinoxidilApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MinoxidilGive supportive measures and symptomatic treatment. Thoroughly wash the hair. In accidental ingestion drug can be removed from the body by inducing emesis or gastric lavage. Absorption of the drug can be reduced by administration of activated charcoalFinasteride
About Finasteride5 Alpha-Reductase Inhibitor, Synthetic anti-androgen.Mechanism of Action of FinasterideThis synthetic 4-azasteroid derivative competitively inhibits steroid 5alpha reductase, which is an enzyme responsible for active androgen dehydrotestosterone (this enzyme influences the development of prostate gland, so decreasing level of this hormone relieve the symptoms associated with benign prostatic hyperplasia)from testosterone.Pharmacokinets of FinasterideAbsorption- Poorly absorbed after oral administration
Distribution- Widely distributed in the body. It crosses the blood-brain barrier. 90% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites. Two metabolites, the t-butyl side chain monohydroxylated and monocarboxylic acid metabolites have been identified that possess not more than 20% of the 5alpha-reductase inhibitory activity of finasteride.
Excretion- It is excreted through urine and feces
Onset of Action for FinasterideAfter a few monthsDuration of Action for Finasteride24hrsHalf Life of FinasterideIts plasma half life is 4.8-6 hoursSide Effects of Finasteride1. Increased libido
2. Breast tenderness
3. Impotence
4. Hypersensitivity reactions.
5. Impotence (inability to have or maintain an erection)
6. Nipple discharge
Contra-indications of FinasterideContraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Finasteride1. Hepatic dysfunction
2. Patients with large residual urine volume
3. Increase in PSA levelPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Finasteride1. Benign prostatic hyperplasia
2. 1st stage of prostate cancer
3. Hirsuitism
4. Acne
5. Adjuvant therapy of radical prostectomy
6. Androgenic baldness
Interactions for FinasterideTheophylline: Increased theophylline clearance and decreased its half-life.Typical Dosage for FinasterideOral-
Adult-
5mg/day for 6 to 12 months
Androgenic baldness: 1mg/day for 3 months or more
Schedule of FinasterideN/AStorage Requirements for FinasterideStore it at room temperature and away from excess heat and moistureEffects of Missed Dosage of FinasterideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FinasterideGive symptomatic and supportive treatmentHome Delivery for Minoxidil + Finasteride in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including minoxidil + finasteride.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for minoxidil + finasteride and other medicines and health products. Home delivery services for minoxidil + finasteride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take minoxidil + finasteride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for minoxidil + finasteride before they complete the sale. You can get this information while placing the order for minoxidil + finasteride with the pharmacy.
Minoxidil + Finasteride is a generic medicine name and there are several brands available for it. Some of the brands for minoxidil + finasteride might be better known than minoxidil + finasteride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have minoxidil + finasteride in stock, you can ask for one of the branded alternatives for minoxidil + finasteride.
