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- Pharmacology For Mosapride + Methyl Polysiloxane
Mosapride + Methyl Polysiloxane Pharmacology
Mosapride + Methyl Polysiloxane
About Mosapride + Methyl PolysiloxaneN/AMechanism of Action of Mosapride + Methyl PolysiloxaneN/APharmacokinets of Mosapride + Methyl PolysiloxaneN/AOnset of Action for Mosapride + Methyl PolysiloxaneN/ADuration of Action for Mosapride + Methyl PolysiloxaneN/AHalf Life of Mosapride + Methyl PolysiloxaneN/ASide Effects of Mosapride + Methyl PolysiloxaneN/AContra-indications of Mosapride + Methyl PolysiloxaneN/ASpecial Precautions while taking Mosapride + Methyl PolysiloxaneN/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationContrindicatedIndications for Mosapride + Methyl PolysiloxaneDyspepsia with flatulence.Interactions for Mosapride + Methyl PolysiloxaneN/ATypical Dosage for Mosapride + Methyl PolysiloxaneOne tab tidSchedule of Mosapride + Methyl PolysiloxaneN/AStorage Requirements for Mosapride + Methyl PolysiloxaneN/AEffects of Missed Dosage of Mosapride + Methyl PolysiloxaneN/AEffects of Overdose of Mosapride + Methyl PolysiloxaneN/AMosapride
About MosaprideA selective 5HT4 agonist, A gastroprokinetic agent.Mechanism of Action of MosaprideMosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of MosaprideAbsorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.
Onset of Action for MosaprideN/ADuration of Action for MosaprideN/AHalf Life of Mosapride2 - 3 hoursSide Effects of Mosapride1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Dry mouth
5.Nausea
Contra-indications of Mosapride1.Hypersensitivity to MosaprideSpecial Precautions while taking Mosapride1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES: contraindicated
Indications for Mosapride1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
5.Nausea
Interactions for MosaprideMosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride. Typical Dosage for MosaprideAdult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of MosaprideN/AStorage Requirements for MosaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of MosaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MosaprideGive supportive measures and symptomatic treatment.
Methyl Polysiloxane
About Methyl PolysiloxaneSiloxanes, Antiflatulent.Mechanism of Action of Methyl PolysiloxaneMethyl Polysiloxane relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas.Pharmacokinets of Methyl PolysiloxaneN/AOnset of Action for Methyl PolysiloxaneN/ADuration of Action for Methyl PolysiloxaneN/AHalf Life of Methyl PolysiloxaneN/ASide Effects of Methyl PolysiloxaneN/AContra-indications of Methyl PolysiloxaneHypersensitivity to Methyl PolysiloxaneSpecial Precautions while taking Methyl PolysiloxaneKidney failurePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methyl Polysiloxane1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Methyl PolysiloxaneN/ATypical Dosage for Methyl Polysiloxane125 - 166 mg taken half an hour before food.
Methyl Polysiloxane in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Methyl Polysiloxane
Schedule of Methyl PolysiloxaneN/AStorage Requirements for Methyl PolysiloxaneStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of Methyl PolysiloxaneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Methyl PolysiloxaneGive symptomatic and supportive treatment.Home Delivery for Mosapride + Methyl Polysiloxane in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mosapride + methyl polysiloxane.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride + methyl polysiloxane and other medicines and health products. Home delivery services for mosapride + methyl polysiloxane may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take mosapride + methyl polysiloxane only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mosapride + methyl polysiloxane before they complete the sale. You can get this information while placing the order for mosapride + methyl polysiloxane with the pharmacy.
Mosapride + Methyl Polysiloxane is a generic medicine name and there are several brands available for it. Some of the brands for mosapride + methyl polysiloxane might be better known than mosapride + methyl polysiloxane itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride + methyl polysiloxane in stock, you can ask for one of the branded alternatives for mosapride + methyl polysiloxane.
