Mosapride + Pantoprazole Pharmacology

Mosapride + Pantoprazole

About Mosapride + Pantoprazole
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Mechanism of Action of Mosapride + Pantoprazole
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Pharmacokinets of Mosapride + Pantoprazole
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Onset of Action for Mosapride + Pantoprazole
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Duration of Action for Mosapride + Pantoprazole
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Half Life of Mosapride + Pantoprazole
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Side Effects of Mosapride + Pantoprazole
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Contra-indications of Mosapride + Pantoprazole
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Special Precautions while taking Mosapride + Pantoprazole
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
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Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Mosapride + Pantoprazole
1.Acid reflux diseases
2.Irritable bowel syndrome
3.Functional dyspepsia

Interactions for Mosapride + Pantoprazole
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Typical Dosage for Mosapride + Pantoprazole
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Schedule of Mosapride + Pantoprazole
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Storage Requirements for Mosapride + Pantoprazole
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Effects of Missed Dosage of Mosapride + Pantoprazole
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Effects of Overdose of Mosapride + Pantoprazole
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Mosapride

About Mosapride
A selective 5HT4 agonist, A gastroprokinetic agent.
Mechanism of Action of Mosapride
Mosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.
Pharmacokinets of Mosapride
Absorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.

Onset of Action for Mosapride
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Duration of Action for Mosapride
N/A
Half Life of Mosapride
2 - 3 hours
Side Effects of Mosapride
1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Dry mouth
5.Nausea
Contra-indications of Mosapride
1.Hypersensitivity to Mosapride
Special Precautions while taking Mosapride
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Mosapride
1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
5.Nausea
Interactions for Mosapride
Mosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride.
Typical Dosage for Mosapride
Adult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of Mosapride
N/A
Storage Requirements for Mosapride
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Mosapride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Mosapride
Give supportive measures and symptomatic treatment.

Pantoprazole

About Pantoprazole
A proton pump inhibitor, Benzimidazole derivative, Anti ulcer.
Mechanism of Action of Pantoprazole
Pantoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Pantoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Pantoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Pantoprazole is more acid stable and its activity is lowered in higher pH. It is the only proton pump inhibitor which is available as parenteral form.



Pharmacokinets of Pantoprazole
Absorption: Pantoprazole is well absorbed after oral administration. Its bioavailability is about 77% since it`s undergoes first pass metabolism.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Pantoprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Pantoprazole
2-4 hours
Duration of Action for Pantoprazole
1 day
Half Life of Pantoprazole
60 minutes
Side Effects of Pantoprazole
1. Diarrhoea
2. Nausea
3. Vomiting
4. Headache
5. Flatulence
6. Abdominal pain
7. Pruritis
8. Dizziness
9. Rash

Contra-indications of Pantoprazole
1. Hypersensitivity to Pantoprazole
Special Precautions while taking Pantoprazole
1. Hepatic impairment
2. Monitor liver function
3. Avoid prolonged use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
Below 12 years : Contraindicated
Indications for Pantoprazole
1. Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
Interactions for Pantoprazole
Phenazone (antipyrine), diazepam, digoxin, theophylline, carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin, nifedipine, caffeine, metoprolol or ethanol : No clinically relevant interaction at therapeutic doses.
Oral contraceptives : Does not appear to compromise hormonal contraceptive efficacy as no interaction with a low dose combined oral contraceptive has been seen.
Typical Dosage for Pantoprazole
Oral :
Adult: 20-40mg / day before breakfast.
Duodenal ulcer: 40mg / day to be taken before breakfast for 2 - 4 weeks.
Benign Gastric ulcer: 40mg / day to be taken before breakfast for 1 - 2months.
Zollinger- Ellison syndrome: 80 mg / day in 2 divided doses increase the dose to 240 mg/ day if needed.
Gastroesophageal reflux disease: 20 - 40 mg / day to be taken before breakfast for 1 month and continue the treatment for 1 more month if needed.
Parenteral: 40 mg once daily as IV injection over 15 minutes.
Children below 12 years : Not recommended
Schedule of Pantoprazole
H
Storage Requirements for Pantoprazole
Store at 15 - 30 degree C in a tightly closed container. Protect from light.
Effects of Missed Dosage of Pantoprazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pantoprazole
Give supportive measures and symptomatic treatment.

Home Delivery for Mosapride + Pantoprazole in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride + pantoprazole and other medicines and health products. Home delivery services for mosapride + pantoprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mosapride + pantoprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mosapride + pantoprazole before they complete the sale. You can get this information while placing the order for mosapride + pantoprazole with the pharmacy.

Mosapride + Pantoprazole is a generic medicine name and there are several brands available for it. Some of the brands for mosapride + pantoprazole might be better known than mosapride + pantoprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride + pantoprazole in stock, you can ask for one of the branded alternatives for mosapride + pantoprazole.