- Medicine India
- Generic Medicines
- Pharmacology For Duloxetine + Mecobalamin
Duloxetine + Mecobalamin Pharmacology
Duloxetine + MecobalaminAbout Duloxetine + MecobalaminN/AMechanism of Action of Duloxetine + MecobalaminN/APharmacokinets of Duloxetine + MecobalaminN/AOnset of Action for Duloxetine + MecobalaminN/ADuration of Action for Duloxetine + MecobalaminN/AHalf Life of Duloxetine + MecobalaminN/ASide Effects of Duloxetine + MecobalaminN/AContra-indications of Duloxetine + MecobalaminN/ASpecial Precautions while taking Duloxetine + MecobalaminN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Duloxetine + Mecobalamin1.Management of neuropathic pain associated with diabetic peripheral neuropathy, and fibromyalgia
Interactions for Duloxetine + MecobalaminN/ATypical Dosage for Duloxetine + MecobalaminN/ASchedule of Duloxetine + MecobalaminN/AStorage Requirements for Duloxetine + MecobalaminN/AEffects of Missed Dosage of Duloxetine + MecobalaminN/AEffects of Overdose of Duloxetine + MecobalaminN/A
DuloxetineAbout DuloxetineA serotonin-norepinephrine reuptake inhibitor,Thiophene derivative, Antidepressant.Mechanism of Action of DuloxetineDuloxetine preferentially inhibits the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitter Serotonin in the synaptic cleft and produces antidepressant effectPharmacokinets of DuloxetineAbsorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: Duloxetine is extensively metabolised in the liver. Excretion: Excreted mainly through urine and small amount excreted through urine.Onset of Action for DuloxetineN/ADuration of Action for DuloxetineN/AHalf Life of Duloxetine12 hoursSide Effects of Duloxetine1.Diarrhea
Contra-indications of Duloxetine1.Hypersensitivity to Duloxetine
2.Patient on Monoamine Oxidase Inhibitors therapy
3.Uncontrolled Narrow-Angle Glaucoma
4.Severe hepatic impairment
Special Precautions while taking Duloxetine1.Bipolar affective disorder
2.History of mania
5.People with bleeding tendencies
Pregnancy Related InformationcontraindicatedOld Age Related Informationuse with cautionBreast Feeding Related InformationcontraindicatedChildren Related InformationcontraindicatedIndications for Duloxetine1. Major depressive disorder
2. Diabetic Peripheral Neuropathic Pain
3. Generalised anxiety disorder
Interactions for DuloxetineN/ATypical Dosage for DuloxetineMajor Depressive Disorder: 20 - 60mg / day in 2 divided doses
Diabetic Peripheral Neuropathic Pain:60 mg/day
Generalized Anxiety Disorder: 60 mg/ day
Schedule of DuloxetineN/AStorage Requirements for DuloxetineStore at 15 - 25 degree C. Keep out of the reach of children.Effects of Missed Dosage of DuloxetineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of DuloxetineGive supportive measures and symptomatic treatment. Gastric lavage can be done to eliminate the drug from the body. Charcoal can be given to reduce the absorption of the drug.
MecobalaminAbout MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/A
Home Delivery for Duloxetine + Mecobalamin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including duloxetine + mecobalamin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for duloxetine + mecobalamin and other medicines and health products. Home delivery services for duloxetine + mecobalamin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take duloxetine + mecobalamin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for duloxetine + mecobalamin before they complete the sale. You can get this information while placing the order for duloxetine + mecobalamin with the pharmacy.
Duloxetine + Mecobalamin is a generic medicine name and there are several brands available for it. Some of the brands for duloxetine + mecobalamin might be better known than duloxetine + mecobalamin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have duloxetine + mecobalamin in stock, you can ask for one of the branded alternatives for duloxetine + mecobalamin.