Cefaclor Pharmacology


About Cefaclor
A second-generation cephalosporin antibiotic, Oral Broad-spectrum antibiotics.
Mechanism of Action of Cefaclor
Cefaclor is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefaclor inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefaclor.
Cefaclor has more activity against ampicillin resistant haemophilus influenzae and branhamella catarrhalis
Pharmacokinets of Cefaclor
Absorption: well absorbed orally, food delays absorption, Distribution: widely distributed, Metabolism: not metabolized, Excretion: excreted mainly through urine; & small amount is excreted in breast milk
Onset of Action for Cefaclor
Within one hour
Duration of Action for Cefaclor
8 hours
Half Life of Cefaclor
Side Effects of Cefaclor
5.Super infection
8.Hypersensitivity reactions
9.Joint pain
17.Elevated liver enzymes.
Contra-indications of Cefaclor
1.Hypersensitivity to cephalosporins
2.Neuromuscular disorders
Special Precautions while taking Cefaclor
1.Renal impairment
2.Neuromuscular disorders
3.Those allergic to penicillins

Pregnancy Related Information
Use with caution
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Neonates: contraindicated
Indications for Cefaclor
1.Pneumonia & Pulmonary infections
3.Urinary tract infections & genital tract infections
4.Pharyngitis & Tonsillitis
5.Skin & wound infections
6.Bronchitis & Sinusitis
Interactions for Cefaclor
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.
Bacteriostatic agents like Chloramphenicol: Decrease efficacy of Cefaclor.
Probenecid: Slows tubular excretion and this enhances efficacy.
Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefaclor.
Lab.test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb?s Test: False positive.
Urinary 17-Ketosteroid values: Falsely elevated values.

Typical Dosage for Cefaclor
Adults: 0.25gm to 0.5gm orally three times daily or four times daily
Urinary tract infections: 2gm once daily orally
Children: 20mg/kg/day to 40mg/kg/day based on severity of infections

Schedule of Cefaclor
Storage Requirements for Cefaclor
Store in a cool place.

Effects of Missed Dosage of Cefaclor
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefaclor
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures

Home Delivery for Cefaclor in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefaclor.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefaclor and other medicines and health products. Home delivery services for cefaclor may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefaclor only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefaclor before they complete the sale. You can get this information while placing the order for cefaclor with the pharmacy.

Cefaclor is a generic medicine name and there are several brands available for it. Some of the brands for cefaclor might be better known than cefaclor itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefaclor in stock, you can ask for one of the branded alternatives for cefaclor.