Tolperisone Pharmacology

Tolperisone

About Tolperisone
Centrally acting muscle relaxant
Mechanism of Action of Tolperisone
Tolperisone is a centrally acting muscle relaxant.Tolperisone acts at the level of spinal cord by blocking sodium channels and calcium channels. Tolperisone exerts its spinal reflex inhibitory action predominantly via a pre synaptic inhibition of the transmitter release from the primary afferent endings via a combined action on voltage-gated sodium and calcium channels.Tolperisone causes muscle relaxation by its action on central nervous system. It also leads to membrane stabilization & has analgesic activity. This muscle relaxation is dose dependant.
Pharmacokinets of Tolperisone
Absorption: Well absorbed from GI tract. Peak plasma concentration in 0.5-1 hr. Bioavailability: 20%.
Metabolism: Extensively metabolised by liver and kidney
Excretion: Excreted mainly via urine as metabolites.
Onset of Action for Tolperisone
N/A
Duration of Action for Tolperisone
N/A
Half Life of Tolperisone
(IV): 1.5 hrour
Side Effects of Tolperisone
1.Muscular weakness
2.Headache
3.Hypotension
4.Nausea
5Vomiting
6.Abdominal discomfort
Contra-indications of Tolperisone
1.Myasthenia gravis
2.Hypersensitivity
Special Precautions while taking Tolperisone
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated in children below the age of 1 year.
Indications for Tolperisone
1.Acute muscle spasm in back
2.Spasticity in neurological disorders, viz, multiocular sclerosis, myelopathy, encephalomyelitis
3.Spondylosis and arthrosis of large joints
4.Diabetic angiopathy, peripheral vascular disease, thromboangitis obliterans and Raynauds syndrome
Interactions for Tolperisone
Tolperisone may enhance the effects of other neuromuscular blocking agents.
Typical Dosage for Tolperisone
1.The usually recommended dose of Tolperisone hydrochloride in adults is 50 mg tablet given three times a day that can be increased to a maximum daily dose of 600 mg if required.
2.In children, the drug is administered in a daily dose of 5-10 mg/kg/day, given in three divided doses.
3.The dose of the drug should be reduced in the elderly and in patients with hepatic or renal insufficiency.
4.The dosage of the drug should be maintained until the therapeutic effect is reached. Afterwards, the dosage of the drug should be reduced gradually.
Schedule of Tolperisone
N/A
Storage Requirements for Tolperisone
N/A
Effects of Missed Dosage of Tolperisone
N/A
Effects of Overdose of Tolperisone
N/A

Home Delivery for Tolperisone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolperisone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolperisone and other medicines and health products. Home delivery services for tolperisone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tolperisone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolperisone before they complete the sale. You can get this information while placing the order for tolperisone with the pharmacy.

Tolperisone is a generic medicine name and there are several brands available for it. Some of the brands for tolperisone might be better known than tolperisone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolperisone in stock, you can ask for one of the branded alternatives for tolperisone.