Clobetasol Propionate + Nadifloxacin Pharmacology

Clobetasol Propionate + Nadifloxacin

About Clobetasol Propionate + Nadifloxacin
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Mechanism of Action of Clobetasol Propionate + Nadifloxacin
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Pharmacokinets of Clobetasol Propionate + Nadifloxacin
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Onset of Action for Clobetasol Propionate + Nadifloxacin
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Duration of Action for Clobetasol Propionate + Nadifloxacin
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Half Life of Clobetasol Propionate + Nadifloxacin
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Side Effects of Clobetasol Propionate + Nadifloxacin
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Contra-indications of Clobetasol Propionate + Nadifloxacin
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Special Precautions while taking Clobetasol Propionate + Nadifloxacin
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Pregnancy Related Information
Contraindicated
Old Age Related Information
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Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Clobetasol Propionate + Nadifloxacin
1.Acne vulgaris
2.Inflammatory skin diseases
Interactions for Clobetasol Propionate + Nadifloxacin
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Typical Dosage for Clobetasol Propionate + Nadifloxacin
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Schedule of Clobetasol Propionate + Nadifloxacin
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Storage Requirements for Clobetasol Propionate + Nadifloxacin
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Effects of Missed Dosage of Clobetasol Propionate + Nadifloxacin
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Effects of Overdose of Clobetasol Propionate + Nadifloxacin
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Clobetasol propionate

About Clobetasol propionate
Topical adenocorticoid, Anti inflammatory.
Mechanism of Action of Clobetasol propionate
Clobetasol is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation. Thus inhibiting inflammatory mediators and other actions Clobetasol are used for anti-inflammatory conditions.
Pharmacokinets of Clobetasol propionate
Absorption: Clobetasol is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, amount of drug applied and the epidermal barrier (nature of skin)
Onset of Action for Clobetasol propionate
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Duration of Action for Clobetasol propionate
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Half Life of Clobetasol propionate
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Side Effects of Clobetasol propionate
1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis

Contra-indications of Clobetasol propionate
1.Hypersensitivity to Clobetasol and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral,fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Clobetasol propionate
1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes,mouth and mucous membrane
5.Avoid occlusive dressing or plastic damage
6.Not used more than 5 days on the face or in the children
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below12 years: Contraindicated
Indications for Clobetasol propionate
1.Skin disorders
2.Eczema
3.Psoriasis
4.Alopecia areata
5.Inflammation of corticosteroid dermatoses (secondary infected)
6.Chronic discoid lupus Erythematosus
Interactions for Clobetasol propionate
N/A
Typical Dosage for Clobetasol propionate
Topical: Clobetasol 0.05 % cream and gel are available. Medicament is applied thinly and evenly on the affected area. 2 times a day, maximum 2 weeks. Maximum dose: 50 g of the cream/ week.
Schedule of Clobetasol propionate
H
Storage Requirements for Clobetasol propionate
Store at room temperature. Protect from heat, moisture and light. Keep out of the reach of children
Effects of Missed Dosage of Clobetasol propionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clobetasol propionate
Give supportive measures and symptomatic treatment.

Nadifloxacin

About Nadifloxacin
Fluoroquinolone Antibiotic
Mechanism of Action of Nadifloxacin
Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication.It is a potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria, including Propionibacterium acnes and Staphylococcus epidermidis. Nadifloxacin showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), which was similar to potency against methicillin-sensitive Staphylococcus aureus (MSSA). The drug was also active against new quinolone-resistant MRSA.
Pharmacokinets of Nadifloxacin
Absorption:Through Skin
Elimination:Renal
Onset of Action for Nadifloxacin
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Duration of Action for Nadifloxacin
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Half Life of Nadifloxacin
N/A
Side Effects of Nadifloxacin
1.Irritation
2.Pruritus
3.Flushes
4.Papules
5.Skin dryness
6.Felling of facial warmth.
Contra-indications of Nadifloxacin
Hypersensitivity
Special Precautions while taking Nadifloxacin
N/A
Pregnancy Related Information
Use with cautionCaution
Old Age Related Information
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Breast Feeding Related Information
N/A
Children Related Information
Caution in using in premature babies, new borns and infants.
Indications for Nadifloxacin
1.Acne vulgaris
2.Folliculitis and sycosis vulgaris
3.Topical bacterial infections with susceptible bacteria
Interactions for Nadifloxacin
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Typical Dosage for Nadifloxacin
Apply cream two limes a day to lesions. In case of acne washing of face before applying the cream.

Schedule of Nadifloxacin
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Storage Requirements for Nadifloxacin
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Effects of Missed Dosage of Nadifloxacin
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Effects of Overdose of Nadifloxacin
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Home Delivery for Clobetasol Propionate + Nadifloxacin in Your City

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Clobetasol Propionate + Nadifloxacin is a generic medicine name and there are several brands available for it. Some of the brands for clobetasol propionate + nadifloxacin might be better known than clobetasol propionate + nadifloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clobetasol propionate + nadifloxacin in stock, you can ask for one of the branded alternatives for clobetasol propionate + nadifloxacin.