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- Pharmacology For Domperidone + Naproxen
Domperidone + Naproxen Pharmacology
Domperidone + Naproxen
About Domperidone + NaproxenN/AMechanism of Action of Domperidone + NaproxenN/APharmacokinets of Domperidone + NaproxenN/AOnset of Action for Domperidone + NaproxenN/ADuration of Action for Domperidone + NaproxenN/AHalf Life of Domperidone + NaproxenN/ASide Effects of Domperidone + NaproxenN/AContra-indications of Domperidone + NaproxenN/ASpecial Precautions while taking Domperidone + NaproxenN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Domperidone + Naproxen1.Rheumatic disorders
2.Acute musculoskeletal disorders
3.Acute migraine attacks
4.Acute gout
5.Dysmenorrhoea
Interactions for Domperidone + NaproxenN/ATypical Dosage for Domperidone + NaproxenN/ASchedule of Domperidone + NaproxenN/AStorage Requirements for Domperidone + NaproxenN/AEffects of Missed Dosage of Domperidone + NaproxenN/AEffects of Overdose of Domperidone + NaproxenN/ADomperidone
About DomperidoneAntidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.Mechanism of Action of DomperidoneDomperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Pharmacokinets of DomperidoneAbsorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.Onset of Action for Domperidone30 - 60 minutesDuration of Action for Domperidone6 - 8 hoursHalf Life of Domperidone7.5 hoursSide Effects of Domperidone1.Diarrhoea
2.Dry mouth
3.Galactorrhoea
4.Gynaecomastia
5.Skin rash
6.Abdominal discomfort
7.Dystonic reactions
Contra-indications of Domperidone1.Hypersensitivity to Domperidone
2.Prolactin releasing pituitary tumour(prolactinoma)
3.Gastrointestinal obstruction
Special Precautions while taking Domperidone1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Domperidone1.Nausea and vomiting associated with gastrointestinal disorder and migraine.
2.Delayed gastric emptying of functional origin
3.As an Antiemetic in patient receiving cytotoxic drugs
4.Preanaesthetic medication
Interactions for DomperidoneDigoxin: Oral dose of digoxin needs to be reduced.
Aspirin, Paracetamol & Oral Diazepam: Increases absorption of these agents.
Anticholinergic agents: Antagonize the effects of domperidone.
Phenothiazines: CNS depression enhanced by domperidone.
Antimuscarinic agents and opioids: Antagonize GI effects of domperidone.
Suxamethonium: Neuromuscular blockade enhanced by domperidone.Typical Dosage for DomperidoneAdults: 30 - 40 mg / day in 3 - 4 divided doses 30 minutes before meals and at bed time if required. After 2 weeks dose can be increased to 60 - 80 mg / day if needed.
Migraine: 20 mg by mouth may be taken up to every 4 hours with Paracetamol, as required up to a maximum of 4 doses in 24 hours.
Children: 300 mcg / kg body weight 3 - 4 times daily 30 minutes before meals and at bed time if required
Schedule of DomperidoneHStorage Requirements for DomperidoneStore at room temperature (15 - 30 degree C). Protect from direct sun light and moistureEffects of Missed Dosage of DomperidoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DomperidoneGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage and absorption of the drug can be reduced by administration of activated charcoal. To control Extrapyramidal reactions give antiparkinsonian or anticholinergic agents. Naproxen
About NaproxenNSAID, 2-arylpropionic acid (profen) derivative, Analgesic, anti-inflammatory,antipyretic.Mechanism of Action of NaproxenNaproxen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Naproxen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of NaproxenAbsorption: Naproxen is well absorbed after oral administration and its bioavailability is about 95 %.
Distribution: It is distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: Naproxen and its metabolites are excreted mainly in the urine.
Onset of Action for Naproxen1 hoursDuration of Action for Naproxen7 hoursHalf Life of Naproxen10-20 hoursSide Effects of Naproxen1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastrointestinal bleeding
5. Abdominal pain
6. Constipation
7. Peptic ulceration
8. Dyspepsia
9. Headache
10. Drowsiness
11. Oedema
12. Agranulocytosis
13. Neutropenia
14. Thrombocytopenia
15. Dizziness
16. Rash
17. Pruritis
Contra-indications of Naproxen1. Hypersensitivity to Naproxen and other NSAIDs
2. Inflammatory bowel disease
3. Peptic ulcer
4. Severe renal impairment
Special Precautions while taking Naproxen1. Hepatic impairment
2. Renal impairment
3. Hypertension
4. Gastrointestinal diseases
5. Pre existing asthma
6. Oedema
7. Heart failure
8. Myocardial infarction
9. Stroke
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: ContraindicatedIndications for Naproxen1. Rheumatoid arthritis
2. Ankylosing spondylitis
3. Acute gout
4. Joint disorders e.g. inflammatory disease and crystal deposition in the joints
5. Osteoarthritis
6. For the relief of pain and inflammation in dental minor surgery and orthopedic
7. Dysmenorrhoea
8. Juvenile arthritis
9. Migraine
Interactions for NaproxenN/ATypical Dosage for NaproxenAdult: 500 - 1 g / day in 2 divided doses
Pain, Migraine, Dysmenorrhoea, Tendonitis, and Bursitis: Initial dose: 500 mg followed by 250 mg every 6 - 8 hours.
Maximum daily dose after first day: 1250mg
Acute gout: Initial dose: 750 mg followed by 250 mg every 8 hours until attack has subsided.
Children: 5 mg / kg body weight 2 times daily
Schedule of NaproxenHStorage Requirements for NaproxenStore Naproxen at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of NaproxenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NaproxenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Home Delivery for Domperidone + Naproxen in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including domperidone + naproxen.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for domperidone + naproxen and other medicines and health products. Home delivery services for domperidone + naproxen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take domperidone + naproxen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for domperidone + naproxen before they complete the sale. You can get this information while placing the order for domperidone + naproxen with the pharmacy.
Domperidone + Naproxen is a generic medicine name and there are several brands available for it. Some of the brands for domperidone + naproxen might be better known than domperidone + naproxen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have domperidone + naproxen in stock, you can ask for one of the branded alternatives for domperidone + naproxen.
