Naproxen + Paracetamol Pharmacology

Naproxen + Paracetamol

About Naproxen + Paracetamol
N/A
Mechanism of Action of Naproxen + Paracetamol
N/A
Pharmacokinets of Naproxen + Paracetamol
N/A
Onset of Action for Naproxen + Paracetamol
N/A
Duration of Action for Naproxen + Paracetamol
N/A
Half Life of Naproxen + Paracetamol
N/A
Side Effects of Naproxen + Paracetamol
N/A
Contra-indications of Naproxen + Paracetamol
N/A
Special Precautions while taking Naproxen + Paracetamol
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Naproxen + Paracetamol
1.Rheumatic disorders
2.Acute musculoskeletal disorders
3.Migrain
4.Acute gout
Interactions for Naproxen + Paracetamol
N/A
Typical Dosage for Naproxen + Paracetamol
N/A
Schedule of Naproxen + Paracetamol
N/A
Storage Requirements for Naproxen + Paracetamol
N/A
Effects of Missed Dosage of Naproxen + Paracetamol
N/A
Effects of Overdose of Naproxen + Paracetamol
N/A

Naproxen

About Naproxen
NSAID, 2-arylpropionic acid (profen) derivative, Analgesic, anti-inflammatory,antipyretic.
Mechanism of Action of Naproxen
Naproxen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Naproxen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.
Pharmacokinets of Naproxen
Absorption: Naproxen is well absorbed after oral administration and its bioavailability is about 95 %.
Distribution: It is distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: Naproxen and its metabolites are excreted mainly in the urine.
Onset of Action for Naproxen
1 hours
Duration of Action for Naproxen
7 hours
Half Life of Naproxen
10-20 hours
Side Effects of Naproxen
1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastrointestinal bleeding
5. Abdominal pain
6. Constipation
7. Peptic ulceration
8. Dyspepsia
9. Headache
10. Drowsiness
11. Oedema
12. Agranulocytosis
13. Neutropenia
14. Thrombocytopenia
15. Dizziness
16. Rash
17. Pruritis
Contra-indications of Naproxen
1. Hypersensitivity to Naproxen and other NSAIDs
2. Inflammatory bowel disease
3. Peptic ulcer
4. Severe renal impairment
Special Precautions while taking Naproxen
1. Hepatic impairment
2. Renal impairment
3. Hypertension
4. Gastrointestinal diseases
5. Pre existing asthma
6. Oedema
7. Heart failure
8. Myocardial infarction
9. Stroke
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Naproxen
1. Rheumatoid arthritis
2. Ankylosing spondylitis
3. Acute gout
4. Joint disorders e.g. inflammatory disease and crystal deposition in the joints
5. Osteoarthritis
6. For the relief of pain and inflammation in dental minor surgery and orthopedic
7. Dysmenorrhoea
8. Juvenile arthritis
9. Migraine
Interactions for Naproxen
N/A
Typical Dosage for Naproxen
Adult: 500 - 1 g / day in 2 divided doses
Pain, Migraine, Dysmenorrhoea, Tendonitis, and Bursitis: Initial dose: 500 mg followed by 250 mg every 6 - 8 hours.
Maximum daily dose after first day: 1250mg
Acute gout: Initial dose: 750 mg followed by 250 mg every 8 hours until attack has subsided.
Children: 5 mg / kg body weight 2 times daily
Schedule of Naproxen
H
Storage Requirements for Naproxen
Store Naproxen at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Naproxen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Naproxen
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Home Delivery for Naproxen + Paracetamol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including naproxen + paracetamol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for naproxen + paracetamol and other medicines and health products. Home delivery services for naproxen + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take naproxen + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for naproxen + paracetamol before they complete the sale. You can get this information while placing the order for naproxen + paracetamol with the pharmacy.

Naproxen + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for naproxen + paracetamol might be better known than naproxen + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have naproxen + paracetamol in stock, you can ask for one of the branded alternatives for naproxen + paracetamol.