Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc Pharmacology

Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

About Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Mechanism of Action of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Pharmacokinets of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Onset of Action for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Duration of Action for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Half Life of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Side Effects of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Contra-indications of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Special Precautions while taking Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Pregnancy Related Information

Use with caution

Old Age Related Information

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Breast Feeding Related Information

Use with caution

Children Related Information

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Indications for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

1.Diabetic neuropathy
2.Nutritional supplement

Interactions for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Typical Dosage for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Schedule of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Storage Requirements for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Effects of Missed Dosage of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Effects of Overdose of Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc

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Gamma linolenic acid

About Gamma linolenic acid

An essential Fatty acid(omega-6 family), A dietary supplement with antiinflammatory.

Mechanism of Action of Gamma linolenic acid

GLA is metabolized to the 20-carbon polyunsaturated fatty acid DGLA, which is cyclooxygenated to prostaglandin E1 (PGE1). PGE1 elicits biologic activities by binding to surface receptors on smooth muscle cells, increasing intracellular cAMP.
GLA, via conversion to PGE1, exhibits anti-inflammatory, antithrombotic, antiproliferative, and lipid-lowering potential. It also enhances smooth muscle relaxation and vasodilation. In addition, EFAs including GLA are important constituents of membrane phospholipids, including the mitochondrial membrane, where they enhance the integrity and the fluidity of the membrane. Studies have shown that GLA has a role in management of Dry eye, Atopic eczema and cyclical mastalgia (pre-menstrual breast pain).

Pharmacokinets of Gamma linolenic acid

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Onset of Action for Gamma linolenic acid

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Duration of Action for Gamma linolenic acid

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Half Life of Gamma linolenic acid

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Side Effects of Gamma linolenic acid

1.Upset stomach
2.Diarrhea
3.Soft stool
4.Bloating
5.Gas

Contra-indications of Gamma linolenic acid

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Special Precautions while taking Gamma linolenic acid

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Gamma linolenic acid

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Interactions for Gamma linolenic acid

1.Phenothiazines and anticonvulsants due to an increased incidence of seizures.
2.Even though no cases are known of interaction with anticoagulant medications, it may be prudent to closely monitor concomitant usage.
3.Gamma Linolenic acid is shown to reduce tremors from lithium use in manic depressives.

Typical Dosage for Gamma linolenic acid

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Schedule of Gamma linolenic acid

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Storage Requirements for Gamma linolenic acid

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Effects of Missed Dosage of Gamma linolenic acid

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Effects of Overdose of Gamma linolenic acid

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Mecobalamin

About Mecobalamin

Water soluble, Form of Vitamin B12

Mechanism of Action of Mecobalamin

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Pharmacokinets of Mecobalamin

Absorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine

Onset of Action for Mecobalamin

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Duration of Action for Mecobalamin

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Half Life of Mecobalamin

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Side Effects of Mecobalamin

1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site

Contra-indications of Mecobalamin

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Special Precautions while taking Mecobalamin

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Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

N/A

Indications for Mecobalamin

1.Peripheral neuropathies
2.Megaloblastic anaemia

Interactions for Mecobalamin

1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol

Typical Dosage for Mecobalamin

Peripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk

Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.

Schedule of Mecobalamin

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Storage Requirements for Mecobalamin

Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.

Effects of Missed Dosage of Mecobalamin

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Effects of Overdose of Mecobalamin

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Alpha-Lipoic acid

About Alpha-Lipoic acid

Naturally occurring dithiol compound , antioxidant, Agent for neuropathies.

Mechanism of Action of Alpha-Lipoic acid

Alpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.

Pharmacokinets of Alpha-Lipoic acid

Absorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.

Onset of Action for Alpha-Lipoic acid

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Duration of Action for Alpha-Lipoic acid

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Half Life of Alpha-Lipoic acid

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Side Effects of Alpha-Lipoic acid

1.Nausea
2.Vomiting

Contra-indications of Alpha-Lipoic acid

1.Contraindicated during radiotherapy

Special Precautions while taking Alpha-Lipoic acid

Patient with diabetes and problems with glucose intolerance

Pregnancy Related Information

Use with caution

Old Age Related Information

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Breast Feeding Related Information

Use with caution

Children Related Information

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Indications for Alpha-Lipoic acid

1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disorders

Interactions for Alpha-Lipoic acid

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Typical Dosage for Alpha-Lipoic acid

Adult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.

Schedule of Alpha-Lipoic acid

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Storage Requirements for Alpha-Lipoic acid

Store at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.

Effects of Missed Dosage of Alpha-Lipoic acid

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.

Effects of Overdose of Alpha-Lipoic acid

Give supportive measures and symptomatic treatment.

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Typical Dosage for

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Zinc

About Zinc

Trance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.

Mechanism of Action of Zinc

Zinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.

Pharmacokinets of Zinc

Absorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.

Onset of Action for Zinc

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Duration of Action for Zinc

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Half Life of Zinc

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Side Effects of Zinc

1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes

Contra-indications of Zinc

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Special Precautions while taking Zinc

1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction

Pregnancy Related Information

Use with caution

Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Zinc

1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia

Interactions for Zinc

Fluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.

Typical Dosage for Zinc

Adults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.

Schedule of Zinc

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Storage Requirements for Zinc

Store at a temperature below 30 degree C

Effects of Missed Dosage of Zinc

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Zinc

Provide symptomatic treatment and supportive measures

Home Delivery for Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc and other medicines and health products. Home delivery services for gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc before they complete the sale. You can get this information while placing the order for gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc with the pharmacy.

Gamma linolenic acid + Mecobalamin + Alpha-Lipoic acid + Benfothiamine + Zinc is a generic medicine name and there are several brands available for it. Some of the brands for gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc might be better known than gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc in stock, you can ask for one of the branded alternatives for gamma linolenic acid + mecobalamin + alpha-lipoic acid + benfothiamine + zinc.