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Indapamide + Amlodipine Pharmacology
Indapamide + Amlodipine
About Indapamide + AmlodipineN/AMechanism of Action of Indapamide + AmlodipineN/APharmacokinets of Indapamide + AmlodipineN/AOnset of Action for Indapamide + AmlodipineN/ADuration of Action for Indapamide + AmlodipineN/AHalf Life of Indapamide + AmlodipineN/ASide Effects of Indapamide + AmlodipineN/AContra-indications of Indapamide + AmlodipineN/ASpecial Precautions while taking Indapamide + AmlodipineN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Indapamide + AmlodipineHypertensionInteractions for Indapamide + AmlodipineN/ATypical Dosage for Indapamide + AmlodipineN/ASchedule of Indapamide + AmlodipineN/AStorage Requirements for Indapamide + AmlodipineN/AEffects of Missed Dosage of Indapamide + AmlodipineN/AEffects of Overdose of Indapamide + AmlodipineN/AIndapamide
About IndapamideThiazide-related(a non-thiazide sulphonamide) drug, Diuretic, Antihypertensive.Mechanism of Action of IndapamideIt exerts thiazides like diuretic action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion.
It causes vasodilatation by Ca channel blockade. It decreases total peripheral resistance and exerts anti hypertensive action. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Pharmacokinets of IndapamideAbsorption: It is compleately absorbed orally.
Distribution: Widely distributed
Metabolism: Extensively metabolized inside the body, and a small portion reaches tubular fluid.
Excretion: Excreted mainly through urine and rest is excreted through faeces.
Onset of Action for Indapamide1 to 2 hoursDuration of Action for Indapamide24 to 36 hoursHalf Life of IndapamideN/ASide Effects of Indapamide1. Dizziness
2 Headache
3. Orthostatic hypotension
4. Back pain
5. Infection
6. Rhinitis
7. Pharyngitis
8. Sinusitis
9. Vertigo
10 Nausea
11. Diarrhoea
12. Vomiting
13. Constipation
14. Muscle cramps
15. Peripheral edema
16. Polyuria
17. Weakness
18. Hypochloremia
19. Hypokalaemia
20. Hyponatraemia
21. Hyper urecaemia
22. Elevated levels of glucose calcium and lipids
23. Gastro intestinal disturbances
24. Impotence
25. Visual impairment
26. Electrolyte imbalance
27.Ototoxicity
Contra-indications of Indapamide1. Hepatic impairment.
2. Hypersensitivity to the drug
3. Hypersensitivity to Sulfonamides
4. Anuric renal failure
5. Cerebro vascular accidents
Special Precautions while taking Indapamide1. Renal impairment
2. Progressive Liver diseases
3. Hyper urecaemia and Gout
4. Diabetes mellitus
5. Fluid and electrolyte imbalance
6. Cirrhosis
7. Hyper calcaemia
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Indapamide1. Hypertension
2. Oedema
Interactions for IndapamideDiazoxide: Synergistic action - may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity.
Frusemide: Synergy leading to profound diuresis and greater than predicted electroyte loss.
Sulfonylureas: Hypoglycaemic effects enhanced.
Chlorpropamide: Hypokalaemia.
Propantheline: Bioavailability of indapamide increased.
Metoclopramide: Bioavailability of indapamide decreased.
NSAID`s: Natriuretic effect of indapamide decreased. Typical Dosage for IndapamideHyper tension: 1.25mg single daily dose. Increased to 2.5mg if required after 4 weeks.
Maximum dose: 5mg/day
Edema: 2.5mg single daily dose. Increased to 5mg if required after 1 week.
Schedule of IndapamideGStorage Requirements for IndapamideStore at a cool dry place; and at a temperature below 30 degree C. in a well closed container. Keep out of reach of children.Effects of Missed Dosage of IndapamideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Indapamide Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.Amlodipine
About AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
2.Prinzmetal`s angina
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.Home Delivery for Indapamide + Amlodipine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for indapamide + amlodipine and other medicines and health products. Home delivery services for indapamide + amlodipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take indapamide + amlodipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for indapamide + amlodipine before they complete the sale. You can get this information while placing the order for indapamide + amlodipine with the pharmacy.
Indapamide + Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for indapamide + amlodipine might be better known than indapamide + amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have indapamide + amlodipine in stock, you can ask for one of the branded alternatives for indapamide + amlodipine.
