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- Pharmacology For Nebivolol + Valsartan
Nebivolol + Valsartan Pharmacology
Nebivolol + Valsartan
About Nebivolol + ValsartanN/AMechanism of Action of Nebivolol + ValsartanN/APharmacokinets of Nebivolol + ValsartanN/AOnset of Action for Nebivolol + ValsartanN/ADuration of Action for Nebivolol + ValsartanN/AHalf Life of Nebivolol + ValsartanN/ASide Effects of Nebivolol + ValsartanN/AContra-indications of Nebivolol + ValsartanN/ASpecial Precautions while taking Nebivolol + ValsartanN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Nebivolol + ValsartanHypertensionInteractions for Nebivolol + ValsartanN/ATypical Dosage for Nebivolol + ValsartanN/ASchedule of Nebivolol + ValsartanN/AStorage Requirements for Nebivolol + ValsartanN/AEffects of Missed Dosage of Nebivolol + ValsartanN/AEffects of Overdose of Nebivolol + ValsartanN/ANebivolol
About NebivololThird generation cardio selective beta-1 receptor antagonist, Antihypertensive.Mechanism of Action of NebivololNebivolol is a 3rd generation cardio selective beta-1 receptor antagonist which reduces vascular resistance, acutely lowers arterial blood pressure without depressing left ventricular function and exerts anti hypertensive effects. The drug causes coronary vasodilatation and improves myocardial ischaemia through nitric oxide release.Pharmacokinets of NebivololAbsorption: Well absorbed orally, Distribution: It is distributed in to the body, Metabolism: It is extensively metabolized inside the body give active hydroxyl metabolite. Excretion: Excreted mainly through urine and rest of drug is excreted through faecesOnset of Action for Nebivolol2 to 6hoursDuration of Action for NebivololN/AHalf Life of Nebivolol24hoursSide Effects of Nebivolol1.Dizziness
2.Headache
3.Tiredness
4.Gastrointestinal problems
5.Nausea
6.Rash
7.Fatigue
8.Vomiting
9.Diarrhoea
10.Raynaud`s syndrome
11.Paraesthesia
12.Dyspnoea
13.Oedema
Contra-indications of Nebivolol1.Hypersensitivity to the drug
2.Uncontrolled heart failure
3.Second or third degree heart block
4.Cardiogenic shock
5.Bradycardia
6.Phaeochromocytoma
7.Hepatic impairment
8.Sick sinus syndrome
9.Chronic obstructive pulmonary disorders
10.Metabolic acidosis
11.Hypotension
12.Peripheral vascular disorders
13.Along with Verapamil
Special Precautions while taking Nebivolol1.Cardiac insufficiency
2.First degree heart block
3.Prinzmetal angina
4.Raynaud`s syndrome
5.Renal impairment
6.The drug should be gradually withdraw with caution
7.Chronic obstructive pulmonary diseases
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationContraindicated.Indications for Nebivolol1.HypertensionInteractions for NebivololN/ATypical Dosage for Nebivolol5mg once daily
Patients above 65years of age: Starts with 2.5mg and increases to 5mg based on patient`s response
Renal impairment: Starts with 2.5mg and increases to 5mg based on patient`s response
Schedule of NebivololHStorage Requirements for NebivololStore in a dry place below 25 degree C. Keep out of reach of children
Effects of Missed Dosage of NebivololTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NebivololTreatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal to reduce absorption. Treat Bradycardia with atropine. If required administer Isoproterinol with caution; in heart block. Treat hypotension with glucagons and vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosidesValsartan
About ValsartanAngiotensin II receptor antagonist, Antihypertensive.Mechanism of Action of ValsartanIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of ValsartanAbsorption: Absorbed orally, bioavailability is about 25%.
Distribution: It is distributed in to the body in a protein bound form.
Metabolism: About 20% of the drug undergoes metabolism.
Excretion: Excreted mainly through faeces and rest is excreted through urine.
Onset of Action for Valsartan2 hoursDuration of Action for Valsartan24 hoursHalf Life of Valsartan6 hoursSide Effects of Valsartan1. Dizziness
2. Headache
3. Coughing
4. Edema
5. Nausea
6. Abdominal pain
7. Diarrhoea
8. Pharyngitis
9. Rhinitis
10. Sinusitis
11. Upper respiratory tract infections
12. Weakness
13. Arthralgia
14. Neutropenia
15. Fetopathic
16. Precipitate renal failure in renal artery stenosis and in insufficient renal blood flow
17. Rashes
18. Hyperkalemia
Contra-indications of Valsartan1. Hypersensitivity to the drugSpecial Precautions while taking Valsartan1.Renal impairment: Use with caution in renal impairment. Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow.
2.Hepatic impairment: Use with caution in hepatic impairment and dosage adjustment is required.
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6. Use cautiously in volume depleted and salt depleted individuals
7. Patient should be cautiously involve in driving or operating heavy machinery during therapy
8. Avoid alcohol or use with caution during therapy
9. Use with caution in hyperkalemia and along with potassium sparing diuretics
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Valsartan1. HypertensionInteractions for ValsartanPotassium-sparing diuretics (e.g., Spironolactone, Triamterene, Amiloride), Potassium supplements, or Salt substitutes containing potassium: Concomitant use of Valsartan with these drugs will result in hyperkalaemia and in heart failure patients it increases serum creatinine. Typical Dosage for ValsartanStarts with 80mg once daily. Increase the dosage after 2 to 4 weeks intervals depending upon the patient`s response to 160mg once daily or two divided doses or a diuretic should be added if required. Further increase in dosage is depending up on patient`s response.
Maximum dose: 320mg/day.
Schedule of ValsartanHStorage Requirements for ValsartanStore at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container.
Effects of Missed Dosage of ValsartanTake the missed dose as soon as remember; If it is the time of next dose then skip the missed dose and take the regular dose.
Effects of Overdose of ValsartanTreatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal saline.Home Delivery for Nebivolol + Valsartan in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nebivolol + valsartan.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nebivolol + valsartan and other medicines and health products. Home delivery services for nebivolol + valsartan may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take nebivolol + valsartan only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nebivolol + valsartan before they complete the sale. You can get this information while placing the order for nebivolol + valsartan with the pharmacy.
Nebivolol + Valsartan is a generic medicine name and there are several brands available for it. Some of the brands for nebivolol + valsartan might be better known than nebivolol + valsartan itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nebivolol + valsartan in stock, you can ask for one of the branded alternatives for nebivolol + valsartan.
