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- Pharmacology For Cefpodoxime + Dicloxacillin
Cefpodoxime + Dicloxacillin Pharmacology
Cefpodoxime + Dicloxacillin
About Cefpodoxime + DicloxacillinN/AMechanism of Action of Cefpodoxime + DicloxacillinN/APharmacokinets of Cefpodoxime + DicloxacillinN/AOnset of Action for Cefpodoxime + DicloxacillinN/ADuration of Action for Cefpodoxime + DicloxacillinN/AHalf Life of Cefpodoxime + DicloxacillinN/ASide Effects of Cefpodoxime + DicloxacillinN/AContra-indications of Cefpodoxime + DicloxacillinN/ASpecial Precautions while taking Cefpodoxime + DicloxacillinN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Cefpodoxime + Dicloxacillin1.URTI including pharyngitis and tonsilitis
2.Acute exacerbation of chronic bronchitis
3.Acute community acquired pneumonia
4.Acute uncomplicated gonorrhea
5.Uncomplicated urinary tract infection
6.Skin infections
7.Penicillin resistant staphylococci
Interactions for Cefpodoxime + DicloxacillinN/ATypical Dosage for Cefpodoxime + DicloxacillinN/ASchedule of Cefpodoxime + DicloxacillinN/AStorage Requirements for Cefpodoxime + DicloxacillinN/AEffects of Missed Dosage of Cefpodoxime + DicloxacillinN/AEffects of Overdose of Cefpodoxime + DicloxacillinN/ACefpodoxime
About CefpodoximeThird Generation Cephalosporin antibiotic, Oral antibiotic.Mechanism of Action of CefpodoximeCefpodoxime is a 3rd generation cephalosporin which exerts its bactericidal action mainly against gram positive organisms by inhibiting bacterial cell wall synthesis. Cefpodoxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefpodoxime.
It is active against enterobacteriaceae, streptococci ,staphylococci aureus, & H. influenzae.
Pharmacokinets of CefpodoximeAbsorption: Orally well absorbed &food increases absorption rate. Distribution: widely distributed, Metabolism: Its ester prodrug Cefpodoxime proxetil is deesterified in to its active metabolite Cefpodoxime in the body, Excretion: Excreted mainly through urineOnset of Action for CefpodoximeN/ADuration of Action for CefpodoximeN/AHalf Life of CefpodoximeN/ASide Effects of Cefpodoxime1.Rashes & allergic manifestation
2.Vaginitis
3.Pruritus
4.Candidiasis
5.Headache
6.Pseudo membranous colitis
7.Nausea
8.Vomiting
9.Diarrhea
10.Leucopenia
11.Thrombocytopenia
Contra-indications of Cefpodoxime1.Hypersensitivity to cephalosporinsSpecial Precautions while taking Cefpodoxime1.Renal impairment
2.Those allergic to penicillins
3.Neuromuscular disorders
4.Use cautiously along with other nephrotoxic drugs
Pregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related Information(Above 6 months): may be used
Neonates: contraindicatedIndications for Cefpodoxime1.Pneumonia, bronchitis &other respiratory tract infections
2.Sinusitis
3.Urinary tract &genital tract infections
4.Gonorrhea & rectal gonococcal infections
5.Skin infections
6.Otitismedia
7.Tonsillitis, Pharyngitis
Interactions for CefpodoximeAntacids and H2 blockers : Plasma concentration of cefpodoxime proxetil may be decreased by 30%.
Probenecid : Plasma levels of cefpodoxime increased when used concomitantly.
Typical Dosage for CefpodoximeAdults: 0. 2gm twice daily.
Maximum adult dose: Up to 0.8gm/day
Children: 5mg/kg/day
Maximum child dose: 200mg/day
Pneumonia:
Adults: 0. 2gm twice daily for two weeks
Bronchitis:
Adults: 0. 2gm twice daily for 10 days
Gonorrhea:
0.2 gm single dose followed by 0.1gm doxycycline orally twice daily for a week
Pharyngitis & Tonsillitis
Adults: 0.1gm orally twice daily for 10 days
Children: 5mg/kg/day orally twice daily for 5 to 10 days
Urinary tract infections:0.1gm twice daily for a week
Otitismedia (2 to12 years old): 5mg/kg/day
Skin infections: 400mg twice daily for two weeks
Schedule of CefpodoximeHStorage Requirements for CefpodoximeN/AEffects of Missed Dosage of CefpodoximeN/AEffects of Overdose of CefpodoximeN/ADicloxacillin
About DicloxacillinA semisynthetic narrow spectrum beta-lactam antibiotic ofpenicillin class, Penicillinase resistant Antibiotic.Mechanism of Action of DicloxacillinLike other ?-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.Pharmacokinets of DicloxacillinAbsorption :Absorption after oral administration is rapid but incomplete,food delays absorption
Distribution: widespread, highest in kidneys & liver, CSF low
Protein Binding: 96%
Metabolism: hepatic CYP3A4
Excretion: renal, feces
Onset of Action for DicloxacillinN/ADuration of Action for DicloxacillinN/AHalf Life of Dicloxacillin0.7 hourSide Effects of Dicloxacillin1.Diarrhoea
2.Nausea
3.Rash
4.Urticaria
5.Pain and inflammation at injection site
6.Superinfection (including candidiasis)
7.Allergy
8.Transient increases in liver enzymes and bilirubin
Contra-indications of Dicloxacillin1.Hypersensitivity to penicillins,cephalosporins, carbapenems
2.Not to be used in the eye
3.Cholestatic hepatitis associated with the use of dicloxacillin
Special Precautions while taking Dicloxacillin1.Renal impairment
2.Hepatic impairment
Pregnancy Related InformationUse with caution Old Age Related InformationUse with caution Breast Feeding Related InformationExcreted in breast milk, use cautionChildren Related InformationN/AIndications for Dicloxacillin1.Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
2.Staphylococcal skin infections and cellulitis ? including impetigo, otitis externa, folliculitis, boils, carbuncles, and mastitis
3.Pneumonia (adjunct)
4.Osteomyelitis, septic arthritis, throat infections, streptococcus
5.Septicaemia
6.Empirical treatment for endocarditis
7.Surgical prophylaxis
Interactions for Dicloxacillin1.Dicloxacillin decreases anticoagulant effect of warfarin
2.Probenecid prolongs T1/2 of dicloxacillin
3.Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Typical Dosage for DicloxacillinAdult:250 to 500mg in every 6 hours
Paediatric:<40 kg: 12.5-25 mg/kg/day PO divided q6hr
Schedule of DicloxacillinN/AStorage Requirements for DicloxacillinN/AEffects of Missed Dosage of DicloxacillinN/AEffects of Overdose of DicloxacillinN/AHome Delivery for Cefpodoxime + Dicloxacillin in Your City
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Cefpodoxime + Dicloxacillin is a generic medicine name and there are several brands available for it. Some of the brands for cefpodoxime + dicloxacillin might be better known than cefpodoxime + dicloxacillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefpodoxime + dicloxacillin in stock, you can ask for one of the branded alternatives for cefpodoxime + dicloxacillin.
