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- Pharmacology For Mecobalamin + Piracetam
Mecobalamin + Piracetam Pharmacology
Mecobalamin + PiracetamAbout Mecobalamin + PiracetamN/AMechanism of Action of Mecobalamin + PiracetamN/APharmacokinets of Mecobalamin + PiracetamN/AOnset of Action for Mecobalamin + PiracetamN/ADuration of Action for Mecobalamin + PiracetamN/AHalf Life of Mecobalamin + PiracetamN/ASide Effects of Mecobalamin + PiracetamN/AContra-indications of Mecobalamin + PiracetamN/ASpecial Precautions while taking Mecobalamin + PiracetamN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Mecobalamin + Piracetam1.Alcoholic neuropathy
3.Drug induced neuropathy
Interactions for Mecobalamin + PiracetamN/ATypical Dosage for Mecobalamin + PiracetamN/ASchedule of Mecobalamin + PiracetamN/AStorage Requirements for Mecobalamin + PiracetamN/AEffects of Missed Dosage of Mecobalamin + PiracetamN/AEffects of Overdose of Mecobalamin + PiracetamN/A
MecobalaminAbout MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/A
PiracetamAbout PiracetamPyrrolidone derivative, a cyclic derivative of GABA, Nootropic,in cerebrovascular insults and insufficiency.Mechanism of Action of PiracetamPiracetam is a cyclic GABA derivative. It facilitates the movement of information between the brain`s 2 hemispheres via corpus callosum and improves the function of Acetylcholine via muscarinic receptors which are implicated in memory process. Piracetam is also called as Nootropics or cognition enhancer.
Piracetam improves the production of adenosine triphosphate (ATP) which is the energy storage and energy generating molecules within our cells. Piracetam increases the blood flow to the brain and promote cerebral metabolism. It increases brain`s use of glucose and oxygen. It also enhances protein synthesis in the brain.
Piracetam enhances the excitatory neurotransmitter NMDA glutamate receptor which is involved in learning and memory process.
Piracetam modulates calcium and potassium ion channels.
Pharmacokinets of PiracetamAbsorption: It is well absorbed after oral administration.
Excretion: It is excreted mainly through urine.
Onset of Action for Piracetam30 - 60 minutesDuration of Action for Piracetam1 dayHalf Life of Piracetam4 - 5 hoursSide Effects of Piracetam1. Nausea
2. Epigastric distress
3. Skin rash
8. Sleep disturbances
13. Weight gain
Contra-indications of PiracetamN/ASpecial Precautions while taking Piracetam1. Hepatic impairment
2. Renal impairment
3. Cardiac impairment
4. Slowly withdraw the drug with caution
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES : ContraindicatedIndications for Piracetam1. Mental retardation and Dyslexia in children
2. Senile dementia and confusional states of old age
3. Cerebrovascular accidents
4. To reduce impairment of consciousness following brain surgery
Interactions for PiracetamOral anticoagulants: Increased prothrombin time.Typical Dosage for PiracetamAdults: Ischemic stroke: 12gm I.V./20 minutes, followed by 12gm I.V./day for 4 weeks or orally.
Post-stroke complications (aphasia/hemiplegia): 4.8gm/day for 8 weeks.
Age associated problems (memory lapses, vertigo, concentration gap): 2.4-4.8 gm/day for 12 weeks
Learning difficulties: 3 gm/day in 3 divided doses for 1 school year.
Children: 50 mg/kg body weight in 3 separate doses. Once the desired result has been obtained reduce the initial dose by half upto 6-8 weeks.Schedule of PiracetamHStorage Requirements for PiracetamStore below 25 degree C in tightly closed container moisture. Protect from moisture. Keep out of the reach of children.Effects of Missed Dosage of PiracetamTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and take that dose. Do not double the dose. Continue the regular schedule.Effects of Overdose of PiracetamGive supportive measures and symptomatic treatment. Drug can be removed from the body by forced diuresis. In renal insufficiency drug can be removed by dialysis.
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