Nabumetone + Paracetamol Pharmacology

Nabumetone + Paracetamol

About Nabumetone + Paracetamol
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Mechanism of Action of Nabumetone + Paracetamol
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Pharmacokinets of Nabumetone + Paracetamol
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Onset of Action for Nabumetone + Paracetamol
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Duration of Action for Nabumetone + Paracetamol
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Half Life of Nabumetone + Paracetamol
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Side Effects of Nabumetone + Paracetamol
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Contra-indications of Nabumetone + Paracetamol
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Special Precautions while taking Nabumetone + Paracetamol
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Nabumetone + Paracetamol
Pain and inflammation associated with musculoskeletal and joint disorders.
Interactions for Nabumetone + Paracetamol
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Typical Dosage for Nabumetone + Paracetamol
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Schedule of Nabumetone + Paracetamol
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Storage Requirements for Nabumetone + Paracetamol
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Effects of Missed Dosage of Nabumetone + Paracetamol
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Effects of Overdose of Nabumetone + Paracetamol
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Nabumetone

About Nabumetone
NSAID, arylalkanoic acid derivative, Analgesic, anti-inflammatory.
Mechanism of Action of Nabumetone
The parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis, most likely through binding to the COX-1 and COX-2 receptors.Its action is more potent on COX2. This results its antipyretic, analgesics and anti-inflammatory action.
Pharmacokinets of Nabumetone
Absorption- Well absorbed after oral administration. Rapidly it undergoes biotransformation in the plasma to its active metabolite 6-methoxy-2-naphthylacetic acid (6MNA).
Distribution- Widely distributed in the body. 99% bound to plasma proteins
Metabolism-It is metabolized in the liver to its inactive metabolites. Excretion- Excreted through urine and feces
Onset of Action for Nabumetone
N/A
Duration of Action for Nabumetone
N/A
Half Life of Nabumetone
22-30 hours
Side Effects of Nabumetone
1. Diarrhea
2. Constipation
3. Gas
4. Dizziness
5. Headache
6. Dry mouth
7. Sores in the mouth
8. Nervousness
9. Difficulty falling asleep or staying asleep
10. Increased sweating
11. Ringing in the ears
12. Unexpected weight gain
13. Yellowing of the skin or eyes
14. Lack of energy
15. Loss of appetite
16. Upset stomach
17. Pain in the upper right part of the stomach
18. Flu-like symptoms
19. Fever
20. Blisters
21. Rash
22. Itching
23. Hives
24. Swelling of the eyes, face, lips, tongue, throat, arms, hands, feet ankles, or lower legs
25. Difficulty breathing or swallowing
26. Hoarseness
Contra-indications of Nabumetone
1. Hypersensitivity to it
2. Hypersensitivity to other NSAIDs
Special Precautions while taking Nabumetone
1. Renal impairment
2. Hepatic dysfunction
3. Heart failure
4. Hypertension
5. Condition which predispose to fluid retention
6. History of peptic ulcer
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Nabumetone
1. Rheumatoid arthritis
2. Osteoarthritis
3. Inflammatory conditions
4. Soft tissue injuries
5. Migraine
6. Gout
Interactions for Nabumetone
Couramine or other anticoagulants: Risk of ulceration or haemorrhage.
Diuretics: May diminish effectiveness and intensity of renal failure.
Acetaminophen: May increase the risk of renal damage.
Salicylates: May decrease the effectiveness of the drug.
Typical Dosage for Nabumetone
Oral-
Adults-
Osteoarthritis / Rheumatoid arthritis - 1g as a single dose with or without food
Soft tissue injuries- 2g per day taken in divided doses for a maximum of 7 days
Schedule of Nabumetone
N/A
Storage Requirements for Nabumetone
Store it at room temperature and away from excess heat and moisture
Effects of Missed Dosage of Nabumetone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nabumetone
Give symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal for the prevention of further absorption of the drug

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Home Delivery for Nabumetone + Paracetamol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nabumetone + paracetamol and other medicines and health products. Home delivery services for nabumetone + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nabumetone + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nabumetone + paracetamol before they complete the sale. You can get this information while placing the order for nabumetone + paracetamol with the pharmacy.

Nabumetone + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for nabumetone + paracetamol might be better known than nabumetone + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nabumetone + paracetamol in stock, you can ask for one of the branded alternatives for nabumetone + paracetamol.