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- Pharmacology For Nabumetone + Paracetamol
Nabumetone + Paracetamol Pharmacology
Nabumetone + ParacetamolAbout Nabumetone + ParacetamolN/AMechanism of Action of Nabumetone + ParacetamolN/APharmacokinets of Nabumetone + ParacetamolN/AOnset of Action for Nabumetone + ParacetamolN/ADuration of Action for Nabumetone + ParacetamolN/AHalf Life of Nabumetone + ParacetamolN/ASide Effects of Nabumetone + ParacetamolN/AContra-indications of Nabumetone + ParacetamolN/ASpecial Precautions while taking Nabumetone + ParacetamolN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Nabumetone + ParacetamolPain and inflammation associated with musculoskeletal and joint disorders.Interactions for Nabumetone + ParacetamolN/ATypical Dosage for Nabumetone + ParacetamolN/ASchedule of Nabumetone + ParacetamolN/AStorage Requirements for Nabumetone + ParacetamolN/AEffects of Missed Dosage of Nabumetone + ParacetamolN/AEffects of Overdose of Nabumetone + ParacetamolN/A
NabumetoneAbout NabumetoneNSAID, arylalkanoic acid derivative, Analgesic, anti-inflammatory.Mechanism of Action of NabumetoneThe parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis, most likely through binding to the COX-1 and COX-2 receptors.Its action is more potent on COX2. This results its antipyretic, analgesics and anti-inflammatory action.Pharmacokinets of NabumetoneAbsorption- Well absorbed after oral administration. Rapidly it undergoes biotransformation in the plasma to its active metabolite 6-methoxy-2-naphthylacetic acid (6MNA).
Distribution- Widely distributed in the body. 99% bound to plasma proteins
Metabolism-It is metabolized in the liver to its inactive metabolites. Excretion- Excreted through urine and feces
Onset of Action for NabumetoneN/ADuration of Action for NabumetoneN/AHalf Life of Nabumetone22-30 hoursSide Effects of Nabumetone1. Diarrhea
6. Dry mouth
7. Sores in the mouth
9. Difficulty falling asleep or staying asleep
10. Increased sweating
11. Ringing in the ears
12. Unexpected weight gain
13. Yellowing of the skin or eyes
14. Lack of energy
15. Loss of appetite
16. Upset stomach
17. Pain in the upper right part of the stomach
18. Flu-like symptoms
24. Swelling of the eyes, face, lips, tongue, throat, arms, hands, feet ankles, or lower legs
25. Difficulty breathing or swallowing
26. HoarsenessContra-indications of Nabumetone1. Hypersensitivity to it
2. Hypersensitivity to other NSAIDsSpecial Precautions while taking Nabumetone1. Renal impairment
2. Hepatic dysfunction
3. Heart failure
5. Condition which predispose to fluid retention
6. History of peptic ulcer
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Nabumetone1. Rheumatoid arthritis
3. Inflammatory conditions
4. Soft tissue injuries
6. GoutInteractions for NabumetoneCouramine or other anticoagulants: Risk of ulceration or haemorrhage.
Diuretics: May diminish effectiveness and intensity of renal failure.
Acetaminophen: May increase the risk of renal damage.
Salicylates: May decrease the effectiveness of the drug.
Typical Dosage for NabumetoneOral-
Osteoarthritis / Rheumatoid arthritis - 1g as a single dose with or without food
Soft tissue injuries- 2g per day taken in divided doses for a maximum of 7 days
Schedule of NabumetoneN/AStorage Requirements for NabumetoneStore it at room temperature and away from excess heat and moistureEffects of Missed Dosage of NabumetoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NabumetoneGive symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal for the prevention of further absorption of the drug
ParacetamolAbout ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Nabumetone + Paracetamol in Your City
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Nabumetone + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for nabumetone + paracetamol might be better known than nabumetone + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nabumetone + paracetamol in stock, you can ask for one of the branded alternatives for nabumetone + paracetamol.