- Medicine India
- Generic Medicines
- Pharmacology For Nimesulide + Paracetamol + Serratiopeptidase
Nimesulide + Paracetamol + Serratiopeptidase Pharmacology
Nimesulide + Paracetamol + SerratiopeptidaseAbout Nimesulide + Paracetamol + SerratiopeptidaseN/AMechanism of Action of Nimesulide + Paracetamol + SerratiopeptidaseN/APharmacokinets of Nimesulide + Paracetamol + SerratiopeptidaseN/AOnset of Action for Nimesulide + Paracetamol + SerratiopeptidaseN/ADuration of Action for Nimesulide + Paracetamol + SerratiopeptidaseN/AHalf Life of Nimesulide + Paracetamol + SerratiopeptidaseN/ASide Effects of Nimesulide + Paracetamol + SerratiopeptidaseN/AContra-indications of Nimesulide + Paracetamol + SerratiopeptidaseN/ASpecial Precautions while taking Nimesulide + Paracetamol + SerratiopeptidaseN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Nimesulide + Paracetamol + SerratiopeptidasePain and inflammation associated with musculoskeletal and joint disorders.Interactions for Nimesulide + Paracetamol + SerratiopeptidaseN/ATypical Dosage for Nimesulide + Paracetamol + SerratiopeptidaseN/ASchedule of Nimesulide + Paracetamol + SerratiopeptidaseN/AStorage Requirements for Nimesulide + Paracetamol + SerratiopeptidaseN/AEffects of Missed Dosage of Nimesulide + Paracetamol + SerratiopeptidaseN/AEffects of Overdose of Nimesulide + Paracetamol + SerratiopeptidaseN/A
NimesulideAbout NimesulideCOX-2 selective NSAID, Analgesic,antipyretic.Mechanism of Action of NimesulideThis Non Steroidal Anti Inflammatory Drug reduces prostaglandin synthesis by the inhibition of cyclo oxygenase enzyme2 selectively. This is a weaker inhibition .So it produces weaker analgesic property. Its potent anti-inflammatory activity is due to its action on various stages of inflammation. This leads to the inhibition of super oxide anion formation invitro by activated neutrophil, inhibition of histamine release from tissue mast cells and basophiles. Additionally it also prevents platelet activating factor synthesis and metalloproteinase synthesis thus prevents the breakdown of osteoarthritic human cartilage. It also prevent tumor necrosis factor alpha and thus reduce the formation of cytokines. This drug can activate glucocorticoid receptors in the body.Pharmacokinets of NimesulideAbsorption-Completely absorbed after oral administration.
Distribution-Widely distributed in the body and extensively bind to the plasma proteins i.e.99%.
Metabolism-It is metabolized in liver to its metabolites.4-hydroxyl derivative is its one active metabolite.
Excretion - Excreted via urine and bile.
Onset of Action for Nimesulide30 to 60 minutesDuration of Action for Nimesulide8-10 hoursHalf Life of NimesulideIts plasma half life is long-nearly 2daysSide Effects of Nimesulide1. Nausea
4. Heart burn
5. Epigastric pain
7. Skin rash
Contra-indications of Nimesulide1. Hypersensitivity to this drug
2. Active peptic ulcer
3. Hepatic impairment
Special Precautions while taking Nimesulide1. Renal impairment
2. Heart failure
3. Alcohol abuse
5. Crohns disease
7. Gastric ulcer
8. Diabetis mellitus
10. Hepatic failure
11. Rectal irritation or bleeding
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Nimesulide1. Painful inflammatory conditions associated with -
Musculoskeletal system, Dysmenorrhea, Thrombophlebitis, Gout
2. Dental pain
3. ENT infection
5. Rheumatoid arthritis
6. Gynecological disorder
7. Low back pain
8. Post operative pain
Interactions for NimesulideFenofibrate, Salicyclic acid, Valproic acid and Tolbutamide: These drugs displace nimesulide from the plasma binding sites.
Methotrexate and Frusemide: These drugs may be displaced from plasma proteins by nimesulide.
Warfarin: Exercise caution since efficacy may be increased.
Theophylline: Efficacy of slow release theophylline preparations reduced. Typical Dosage for NimesulideOral-
Adults - 100 mg two times daily.
Children - 5mg/kg/day divided in 2 or 3 doses.
Schedule of NimesulideHStorage Requirements for NimesulideStore in cool, dark, dry placeEffects of Missed Dosage of NimesulideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of NimesulideEmpty the stomach if necessary. Symptomatic treatment should be given
ParacetamolAbout ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
SerratiopeptidaseAbout SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
3. Gastric discomfort
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
7. Fibrocystic breast swelling
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.
Home Delivery for Nimesulide + Paracetamol + Serratiopeptidase in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nimesulide + paracetamol + serratiopeptidase.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nimesulide + paracetamol + serratiopeptidase and other medicines and health products. Home delivery services for nimesulide + paracetamol + serratiopeptidase may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take nimesulide + paracetamol + serratiopeptidase only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nimesulide + paracetamol + serratiopeptidase before they complete the sale. You can get this information while placing the order for nimesulide + paracetamol + serratiopeptidase with the pharmacy.
Nimesulide + Paracetamol + Serratiopeptidase is a generic medicine name and there are several brands available for it. Some of the brands for nimesulide + paracetamol + serratiopeptidase might be better known than nimesulide + paracetamol + serratiopeptidase itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nimesulide + paracetamol + serratiopeptidase in stock, you can ask for one of the branded alternatives for nimesulide + paracetamol + serratiopeptidase.