Cefpodoxime Pharmacology


About Cefpodoxime
Third Generation Cephalosporin antibiotic, Oral antibiotic.
Mechanism of Action of Cefpodoxime
Cefpodoxime is a 3rd generation cephalosporin which exerts its bactericidal action mainly against gram positive organisms by inhibiting bacterial cell wall synthesis. Cefpodoxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefpodoxime.
It is active against enterobacteriaceae, streptococci ,staphylococci aureus, & H. influenzae.
Pharmacokinets of Cefpodoxime
Absorption: Orally well absorbed &food increases absorption rate. Distribution: widely distributed, Metabolism: Its ester prodrug Cefpodoxime proxetil is deesterified in to its active metabolite Cefpodoxime in the body, Excretion: Excreted mainly through urine
Onset of Action for Cefpodoxime
Duration of Action for Cefpodoxime
Half Life of Cefpodoxime
Side Effects of Cefpodoxime
1.Rashes & allergic manifestation
6.Pseudo membranous colitis

Contra-indications of Cefpodoxime
1.Hypersensitivity to cephalosporins
Special Precautions while taking Cefpodoxime
1.Renal impairment
2.Those allergic to penicillins
3.Neuromuscular disorders
4.Use cautiously along with other nephrotoxic drugs

Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Children Related Information
(Above 6 months): may be used
Neonates: contraindicated
Indications for Cefpodoxime
1.Pneumonia, bronchitis &other respiratory tract infections
3.Urinary tract &genital tract infections
4.Gonorrhea & rectal gonococcal infections
5.Skin infections
7.Tonsillitis, Pharyngitis
Interactions for Cefpodoxime
Antacids and H2 blockers : Plasma concentration of cefpodoxime proxetil may be decreased by 30%.
Probenecid : Plasma levels of cefpodoxime increased when used concomitantly.

Typical Dosage for Cefpodoxime
Adults: 0. 2gm twice daily.
Maximum adult dose: Up to 0.8gm/day
Children: 5mg/kg/day
Maximum child dose: 200mg/day
Adults: 0. 2gm twice daily for two weeks
Adults: 0. 2gm twice daily for 10 days
0.2 gm single dose followed by 0.1gm doxycycline orally twice daily for a week
Pharyngitis & Tonsillitis
Adults: 0.1gm orally twice daily for 10 days
Children: 5mg/kg/day orally twice daily for 5 to 10 days
Urinary tract infections:0.1gm twice daily for a week
Otitismedia (2 to12 years old): 5mg/kg/day
Skin infections: 400mg twice daily for two weeks
Schedule of Cefpodoxime
Storage Requirements for Cefpodoxime
Effects of Missed Dosage of Cefpodoxime
Effects of Overdose of Cefpodoxime

Home Delivery for Cefpodoxime in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefpodoxime.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefpodoxime and other medicines and health products. Home delivery services for cefpodoxime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefpodoxime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefpodoxime before they complete the sale. You can get this information while placing the order for cefpodoxime with the pharmacy.

Cefpodoxime is a generic medicine name and there are several brands available for it. Some of the brands for cefpodoxime might be better known than cefpodoxime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefpodoxime in stock, you can ask for one of the branded alternatives for cefpodoxime.