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- Pharmacology For Alpha-Lipoic Acid + Vitamins
Alpha-Lipoic Acid + Vitamins Pharmacology
Alpha-Lipoic Acid + VitaminsAbout Alpha-Lipoic Acid + VitaminsN/AMechanism of Action of Alpha-Lipoic Acid + VitaminsN/APharmacokinets of Alpha-Lipoic Acid + VitaminsN/AOnset of Action for Alpha-Lipoic Acid + VitaminsN/ADuration of Action for Alpha-Lipoic Acid + VitaminsN/AHalf Life of Alpha-Lipoic Acid + VitaminsN/ASide Effects of Alpha-Lipoic Acid + VitaminsN/AContra-indications of Alpha-Lipoic Acid + VitaminsN/ASpecial Precautions while taking Alpha-Lipoic Acid + VitaminsN/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Alpha-Lipoic Acid + Vitamins1.Diabetic And Peripheral Neuropathy
Interactions for Alpha-Lipoic Acid + VitaminsN/ATypical Dosage for Alpha-Lipoic Acid + VitaminsN/ASchedule of Alpha-Lipoic Acid + VitaminsN/AStorage Requirements for Alpha-Lipoic Acid + VitaminsN/AEffects of Missed Dosage of Alpha-Lipoic Acid + VitaminsN/AEffects of Overdose of Alpha-Lipoic Acid + VitaminsN/A
Alpha-Lipoic acidAbout Alpha-Lipoic acidNaturally occurring dithiol compound , antioxidant, Agent for neuropathies.Mechanism of Action of Alpha-Lipoic acidAlpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.
Pharmacokinets of Alpha-Lipoic acidAbsorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.
Onset of Action for Alpha-Lipoic acidN/ADuration of Action for Alpha-Lipoic acidN/AHalf Life of Alpha-Lipoic acidN/ASide Effects of Alpha-Lipoic acid1.Nausea
2.VomitingContra-indications of Alpha-Lipoic acid1.Contraindicated during radiotherapySpecial Precautions while taking Alpha-Lipoic acidPatient with diabetes and problems with glucose intolerancePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Alpha-Lipoic acid1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disordersInteractions for Alpha-Lipoic acidN/ATypical Dosage for Alpha-Lipoic acidAdult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.Schedule of Alpha-Lipoic acidN/AStorage Requirements for Alpha-Lipoic acidStore at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.Effects of Missed Dosage of Alpha-Lipoic acidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of Alpha-Lipoic acidGive supportive measures and symptomatic treatment.
VitaminsAbout VitaminsVitamins are substances that are found in foods we eat. The term vitamin is derived from the words vital and amine, because vitamins are required for life and were originally thought to be amines. All vitamins are not amines. Vitamins are different in their chemistry, but they all are organic nutrients that are necessary in small amounts for normal metabolism and good health. Most vitamins must be provided by the diet or by supplements; only three vitamins (D, K, and the B vitamin biotin) can be manufactured in the body from non dietary sources. Vitamins are not sources of energy as are carbohydrates, fats, and proteins. Instead, vitamins serve as chemical partners for the enzymes involved in the body`s metabolism, cell production, tissue repair, and other vital processes. Vitamins serve crucial functions in almost all bodily processes example immune, hormonal and nervous systems.
In humans there are thirteen vitamins, divided into two groups. They are fat soluble and water soluble. Fat-soluble vitamins are stored in the fat tissues in your body and in your liver. They go and wait around in your body fat until your body needs them. Water-soluble vitamins are different. Water-soluble vitamins, the vitamins don`t get stored as much in body. Instead, they travel through bloodstream comes out when urinate if body don`t used it.
In humans there are thirteen vitamins, divided into two groups; four fat-soluble vitamins (A, D, E and K), and nine water-soluble vitamins (eight B vitamins and vitamin C).
Mechanism of Action of VitaminsN/APharmacokinets of VitaminsN/AOnset of Action for VitaminsN/ADuration of Action for VitaminsN/AHalf Life of VitaminsN/ASide Effects of VitaminsN/AContra-indications of VitaminsN/ASpecial Precautions while taking VitaminsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for VitaminsN/AInteractions for VitaminsN/ATypical Dosage for VitaminsN/ASchedule of VitaminsN/AStorage Requirements for VitaminsN/AEffects of Missed Dosage of VitaminsN/AEffects of Overdose of VitaminsN/A
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