Ceftazidime Pharmacology


About Ceftazidime
Third Generation Cephalosporin antibiotic, Parenteral antibiotic.
Mechanism of Action of Ceftazidime
Ceftazidime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftazidime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftazidime.It is more active against pseudomonas.
Pharmacokinets of Ceftazidime
Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not metabolized in the body. Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Onset of Action for Ceftazidime
Duration of Action for Ceftazidime
8 hours
Half Life of Ceftazidime
1.8 hours
Side Effects of Ceftazidime
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestation
9.Pseudo membranous colitis
12.Elevated liver enzymes
Contra-indications of Ceftazidime
1.Hypersensitivity to the drug or other cephalosporins
2.Never administer along with chloramphenicol.
Special Precautions while taking Ceftazidime
1.Renal impairment
2.Those allergic to penicillins
3. Neuromuscular disorders
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used, but arginine containing formulation like ceptaz is contraindicated
Neonates: may be used ,but arginine containing formulation like ceptaz is contraindicated
Indications for Ceftazidime
1.Febrile neutropenic patients with haematological malignancies
2.Burn infections
3.Respiratory tract infections
4.Urinogenital tract infections
5.Bone & Joint infections
7.CNS infections
8.Skin & wound infections
Interactions for Ceftazidime
No known interaction.
Typical Dosage for Ceftazidime
Adults: 0.5g to 2gm I.M. or I.V. three times daily.
Children: 30 to 50 mg/kg/day I.M or I.V. three times daily.
Neonates: 30mg/kg I.V. two times daily
Schedule of Ceftazidime
Storage Requirements for Ceftazidime
Store in a refrigerator at -20 degree celciousss
Effects of Missed Dosage of Ceftazidime
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Ceftazidime
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive

Home Delivery for Ceftazidime in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ceftazidime.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ceftazidime and other medicines and health products. Home delivery services for ceftazidime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ceftazidime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ceftazidime before they complete the sale. You can get this information while placing the order for ceftazidime with the pharmacy.

Ceftazidime is a generic medicine name and there are several brands available for it. Some of the brands for ceftazidime might be better known than ceftazidime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ceftazidime in stock, you can ask for one of the branded alternatives for ceftazidime.