Etoricoxib + Paracetamol Pharmacology
Etoricoxib + Paracetamol
2.Osteoarthritis
3.Ankylosing spondylitis
4.Chronic low back pain
5.Acute pain and gout
Etoricoxib
Distribution- Widely distributed in the body
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine and feces
2. Taste disturbances
3. Mouth ulcers
4. Flatulence
5. Constipation
6. Appetite and weight changes
7. Chest pain
8. Fatigue
9. Paresthesia
10. Myalgia
11. Rash
12. Blurred vision
13. Insomnia
14. Muscle cramps
15. Ulceration of the stomach or intestine
16. Cold or flu-like symptoms
17. Dizziness
18. Excessive fluid retention in the body tissues, resulting in swelling (oedema)
19. Epistaxis
20. Difficulty in breathing (dyspnoea)
21. Weakness or loss of strength (asthenia)
22. High blood pressure (hypertension)
23. Anxiety
24. Headache
2. Hyper sensitivity to other NSAID
3. Active peptic ulceration
4. Inflammatory bowel disease
5. Severe congestive heart failure
2. Renal impairment
3. Cardiac diseases
4. Hepatic impairment
2. Osteoarthritis
3. Acute gouty Arthritis
ACE inhibitors : Antihypertensive effects of captopril may be blunted or completely abolished by etoricoxib.
b-Blockers : Antihypertensive effect may be blunted.
Cyclosporine : Nephrotoxicity of both agents may be increased.
Digoxin : Serum digoxin levels may be increased by ibuprofen and etoricoxib.
Hydantoins : Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium : Serum lithium levels may be increased.
Loop diuretics : Decreased effects.
Methotrexate : Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates : displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics : Rofecoxib coadministration may result in increased blood pressure.
Thiazide diuretics : Naproxen and etoricoxib may cause decreased antihypertensive and diuretic action.
Osteoarthritis- 60 mg once daily
Rheumatoid Arthritis- 90 mg once daily
Acute gouty Arthritis-120 mg once daily
Paracetamol
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
2. Abdominal distress
3. Allergic reactions
4. Rash
2. Renal impairment
3. Hypertension
NEONATES : Contraindicated
2. Acute gout
3. Migraine
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Etoricoxib + Paracetamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including etoricoxib + paracetamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for etoricoxib + paracetamol and other medicines and health products. Home delivery services for etoricoxib + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take etoricoxib + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for etoricoxib + paracetamol before they complete the sale. You can get this information while placing the order for etoricoxib + paracetamol with the pharmacy.
Etoricoxib + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for etoricoxib + paracetamol might be better known than etoricoxib + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etoricoxib + paracetamol in stock, you can ask for one of the branded alternatives for etoricoxib + paracetamol.
