Etoricoxib + Thiocolchicoside Pharmacology

Etoricoxib + Thiocolchicoside

About Etoricoxib + Thiocolchicoside
N/A
Mechanism of Action of Etoricoxib + Thiocolchicoside
N/A
Pharmacokinets of Etoricoxib + Thiocolchicoside
N/A
Onset of Action for Etoricoxib + Thiocolchicoside
N/A
Duration of Action for Etoricoxib + Thiocolchicoside
N/A
Half Life of Etoricoxib + Thiocolchicoside
N/A
Side Effects of Etoricoxib + Thiocolchicoside
N/A
Contra-indications of Etoricoxib + Thiocolchicoside
N/A
Special Precautions while taking Etoricoxib + Thiocolchicoside
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Etoricoxib + Thiocolchicoside
1.Rheumatoid arthritis
2.Osteoarthritis
3.Ankylosing spondylitis
4.Chronic low back pain
5.Acute pain and gout
Interactions for Etoricoxib + Thiocolchicoside
N/A
Typical Dosage for Etoricoxib + Thiocolchicoside
N/A
Schedule of Etoricoxib + Thiocolchicoside
N/A
Storage Requirements for Etoricoxib + Thiocolchicoside
N/A
Effects of Missed Dosage of Etoricoxib + Thiocolchicoside
N/A
Effects of Overdose of Etoricoxib + Thiocolchicoside
N/A

Etoricoxib

About Etoricoxib
NSAID, selective COX-2 inhibitor, Analgesic,Anti-inflammatory,Antiarthritic.
Mechanism of Action of Etoricoxib
This NSAID is a selective COX2 inhibitor (blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases. These prostaglandins cause pain, swelling and inflammation). This inhibition results the analgesics and anti-inflammatory action peripherally
Pharmacokinets of Etoricoxib
Absorption- Well absorbed after administration
Distribution- Widely distributed in the body
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine and feces
Onset of Action for Etoricoxib
24 min
Duration of Action for Etoricoxib
24 hrs
Half Life of Etoricoxib
Its plasma half life is 22 hrs
Side Effects of Etoricoxib
1. Dry mouth
2. Taste disturbances
3. Mouth ulcers
4. Flatulence
5. Constipation
6. Appetite and weight changes
7. Chest pain
8. Fatigue
9. Paresthesia
10. Myalgia
11. Rash
12. Blurred vision
13. Insomnia
14. Muscle cramps
15. Ulceration of the stomach or intestine
16. Cold or flu-like symptoms
17. Dizziness
18. Excessive fluid retention in the body tissues, resulting in swelling (oedema)
19. Epistaxis
20. Difficulty in breathing (dyspnoea)
21. Weakness or loss of strength (asthenia)
22. High blood pressure (hypertension)
23. Anxiety
24. Headache
Contra-indications of Etoricoxib
1. Hypersensitivity to the drug
2. Hyper sensitivity to other NSAID
3. Active peptic ulceration
4. Inflammatory bowel disease
5. Severe congestive heart failure
Special Precautions while taking Etoricoxib
1. Allergic disorders
2. Renal impairment
3. Cardiac diseases
4. Hepatic impairment
Pregnancy Related Information
Contraindicated

Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Etoricoxib
1. Rheumatoid Arthritis
2. Osteoarthritis
3. Acute gouty Arthritis
Interactions for Etoricoxib
Anticoagulants : May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding.
ACE inhibitors : Antihypertensive effects of captopril may be blunted or completely abolished by etoricoxib.
b-Blockers : Antihypertensive effect may be blunted.
Cyclosporine : Nephrotoxicity of both agents may be increased.
Digoxin : Serum digoxin levels may be increased by ibuprofen and etoricoxib.
Hydantoins : Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium : Serum lithium levels may be increased.
Loop diuretics : Decreased effects.
Methotrexate : Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates : displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics : Rofecoxib coadministration may result in increased blood pressure.
Thiazide diuretics : Naproxen and etoricoxib may cause decreased antihypertensive and diuretic action.
Typical Dosage for Etoricoxib
Oral- Adults-
Osteoarthritis- 60 mg once daily
Rheumatoid Arthritis- 90 mg once daily
Acute gouty Arthritis-120 mg once daily

Schedule of Etoricoxib
N/A
Storage Requirements for Etoricoxib
Store at room temperature away from moisture and heat
Effects of Missed Dosage of Etoricoxib
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Etoricoxib
Give symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.

Thiocolchicoside

About Thiocolchicoside
A GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant.
Mechanism of Action of Thiocolchicoside
Thiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.
Pharmacokinets of Thiocolchicoside
N/A
Onset of Action for Thiocolchicoside
N/A
Duration of Action for Thiocolchicoside
N/A
Half Life of Thiocolchicoside
N/A
Side Effects of Thiocolchicoside
1. Diarrhoea
2. Gastralgia
3. Nausea
4. Vomiting
5. Drowsiness
6. Anaphylactic reaction
Contra-indications of Thiocolchicoside
1. Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Thiocolchicoside
1. Use with caution in patients with diarrhea
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Thiocolchicoside
Painful muscle spasm associated with
1. Degenerative vertebral disorders
2. Torticollis
3. Dorsal pain
4. Low back pain
5. Traumatological disorders
6. Neurological disorders
Interactions for Thiocolchicoside
No known interactions with other drugs.
Typical Dosage for Thiocolchicoside
Adult-
Oral- 4mg twice a day for 5 to 7 days.
Intramuscular-
4mg twice a day for 3 to 5 days.
Schedule of Thiocolchicoside
N/A
Storage Requirements for Thiocolchicoside
N/A
Effects of Missed Dosage of Thiocolchicoside
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Thiocolchicoside
Give symptomatic and supportive treatment.

Home Delivery for Etoricoxib + Thiocolchicoside in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for etoricoxib + thiocolchicoside and other medicines and health products. Home delivery services for etoricoxib + thiocolchicoside may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take etoricoxib + thiocolchicoside only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for etoricoxib + thiocolchicoside before they complete the sale. You can get this information while placing the order for etoricoxib + thiocolchicoside with the pharmacy.

Etoricoxib + Thiocolchicoside is a generic medicine name and there are several brands available for it. Some of the brands for etoricoxib + thiocolchicoside might be better known than etoricoxib + thiocolchicoside itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etoricoxib + thiocolchicoside in stock, you can ask for one of the branded alternatives for etoricoxib + thiocolchicoside.