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- Pharmacology For Etoricoxib + Thiocolchicoside
Etoricoxib + Thiocolchicoside Pharmacology
Etoricoxib + ThiocolchicosideAbout Etoricoxib + ThiocolchicosideN/AMechanism of Action of Etoricoxib + ThiocolchicosideN/APharmacokinets of Etoricoxib + ThiocolchicosideN/AOnset of Action for Etoricoxib + ThiocolchicosideN/ADuration of Action for Etoricoxib + ThiocolchicosideN/AHalf Life of Etoricoxib + ThiocolchicosideN/ASide Effects of Etoricoxib + ThiocolchicosideN/AContra-indications of Etoricoxib + ThiocolchicosideN/ASpecial Precautions while taking Etoricoxib + ThiocolchicosideN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Etoricoxib + Thiocolchicoside1.Rheumatoid arthritis
4.Chronic low back pain
5.Acute pain and gout
Interactions for Etoricoxib + ThiocolchicosideN/ATypical Dosage for Etoricoxib + ThiocolchicosideN/ASchedule of Etoricoxib + ThiocolchicosideN/AStorage Requirements for Etoricoxib + ThiocolchicosideN/AEffects of Missed Dosage of Etoricoxib + ThiocolchicosideN/AEffects of Overdose of Etoricoxib + ThiocolchicosideN/A
EtoricoxibAbout EtoricoxibNSAID, selective COX-2 inhibitor, Analgesic,Anti-inflammatory,Antiarthritic.Mechanism of Action of EtoricoxibThis NSAID is a selective COX2 inhibitor (blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases. These prostaglandins cause pain, swelling and inflammation). This inhibition results the analgesics and anti-inflammatory action peripherallyPharmacokinets of EtoricoxibAbsorption- Well absorbed after administration
Distribution- Widely distributed in the body
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine and feces
Onset of Action for Etoricoxib24 minDuration of Action for Etoricoxib24 hrsHalf Life of EtoricoxibIts plasma half life is 22 hrsSide Effects of Etoricoxib1. Dry mouth
2. Taste disturbances
3. Mouth ulcers
6. Appetite and weight changes
7. Chest pain
12. Blurred vision
14. Muscle cramps
15. Ulceration of the stomach or intestine
16. Cold or flu-like symptoms
18. Excessive fluid retention in the body tissues, resulting in swelling (oedema)
20. Difficulty in breathing (dyspnoea)
21. Weakness or loss of strength (asthenia)
22. High blood pressure (hypertension)
Contra-indications of Etoricoxib1. Hypersensitivity to the drug
2. Hyper sensitivity to other NSAID
3. Active peptic ulceration
4. Inflammatory bowel disease
5. Severe congestive heart failureSpecial Precautions while taking Etoricoxib1. Allergic disorders
2. Renal impairment
3. Cardiac diseases
4. Hepatic impairmentPregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Etoricoxib1. Rheumatoid Arthritis
3. Acute gouty ArthritisInteractions for EtoricoxibAnticoagulants : May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding.
ACE inhibitors : Antihypertensive effects of captopril may be blunted or completely abolished by etoricoxib.
b-Blockers : Antihypertensive effect may be blunted.
Cyclosporine : Nephrotoxicity of both agents may be increased.
Digoxin : Serum digoxin levels may be increased by ibuprofen and etoricoxib.
Hydantoins : Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium : Serum lithium levels may be increased.
Loop diuretics : Decreased effects.
Methotrexate : Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates : displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics : Rofecoxib coadministration may result in increased blood pressure.
Thiazide diuretics : Naproxen and etoricoxib may cause decreased antihypertensive and diuretic action.Typical Dosage for EtoricoxibOral- Adults-
Osteoarthritis- 60 mg once daily
Rheumatoid Arthritis- 90 mg once daily
Acute gouty Arthritis-120 mg once daily
Schedule of EtoricoxibN/AStorage Requirements for EtoricoxibStore at room temperature away from moisture and heatEffects of Missed Dosage of EtoricoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of EtoricoxibGive symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.
ThiocolchicosideAbout ThiocolchicosideA GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant.Mechanism of Action of ThiocolchicosideThiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.Pharmacokinets of ThiocolchicosideN/AOnset of Action for ThiocolchicosideN/ADuration of Action for ThiocolchicosideN/AHalf Life of ThiocolchicosideN/ASide Effects of Thiocolchicoside1. Diarrhoea
6. Anaphylactic reaction
Contra-indications of Thiocolchicoside1. Contraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Thiocolchicoside1. Use with caution in patients with diarrheaPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for ThiocolchicosidePainful muscle spasm associated with
1. Degenerative vertebral disorders
3. Dorsal pain
4. Low back pain
5. Traumatological disorders
6. Neurological disorders
Interactions for ThiocolchicosideNo known interactions with other drugs.Typical Dosage for ThiocolchicosideAdult-
Oral- 4mg twice a day for 5 to 7 days.
4mg twice a day for 3 to 5 days.
Schedule of ThiocolchicosideN/AStorage Requirements for ThiocolchicosideN/AEffects of Missed Dosage of ThiocolchicosideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ThiocolchicosideGive symptomatic and supportive treatment.
Home Delivery for Etoricoxib + Thiocolchicoside in Your City
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Etoricoxib + Thiocolchicoside is a generic medicine name and there are several brands available for it. Some of the brands for etoricoxib + thiocolchicoside might be better known than etoricoxib + thiocolchicoside itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etoricoxib + thiocolchicoside in stock, you can ask for one of the branded alternatives for etoricoxib + thiocolchicoside.