Ceftriaxone Pharmacology


About Ceftriaxone
Third Generation Cephalosporin antibiotic(Parenteral).
Mechanism of Action of Ceftriaxone
Ceftriaxone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftriaxone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftriaxone.

Pharmacokinets of Ceftriaxone
Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: A portion of the drug is metabolized in the body. Excretion:
Excreted through urine & bile. A small portion of drug appears in breast milk.
Onset of Action for Ceftriaxone
Duration of Action for Ceftriaxone
8 hours
Half Life of Ceftriaxone
Side Effects of Ceftriaxone
5.Skin rash
7.Pseudomembranous colitis
8.Pain at site of injection
Contra-indications of Ceftriaxone
Hypersensitivity to Ceftriaxone
Special Precautions while taking Ceftriaxone
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Neonates: Use with caution
Indications for Ceftriaxone
5.Prophylaxis in surgical infections
6.Lower respiratory tract infections
8.Pelvic inflammatory disease
Interactions for Ceftriaxone
Alcohol: Disulfiram like reaction.
Aminoglycosides & fruesmide: Nephrotoxicity potentiated.
Chloramphenicol: Decreased efficacy of ceftriaxone.
Typical Dosage for Ceftriaxone
Adults: 1g to 2gm I.M. or I.V. Once daily or two times daily
Maximum adult dose: Up to 4gm/day
Meningitis & Endocarditis: 1 to 2gm I.M. or I.V twice daily; two weeks for meningitis & four weeks for endocarditis
Gonorrhea: 250mg once daily

Children: 50 to 100 mg/kg/day I.M or I.V. two times daily
Maximum child dose: 2g/day
Meningitis & Endocarditis: 50 to 100 mg/kg/day twice daily; two weeks for meningitis & four weeks for endocarditis

Schedule of Ceftriaxone
Storage Requirements for Ceftriaxone
Effects of Missed Dosage of Ceftriaxone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ceftriaxone
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment is supportive.

Home Delivery for Ceftriaxone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ceftriaxone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ceftriaxone and other medicines and health products. Home delivery services for ceftriaxone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ceftriaxone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ceftriaxone before they complete the sale. You can get this information while placing the order for ceftriaxone with the pharmacy.

Ceftriaxone is a generic medicine name and there are several brands available for it. Some of the brands for ceftriaxone might be better known than ceftriaxone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ceftriaxone in stock, you can ask for one of the branded alternatives for ceftriaxone.