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- Pharmacology For Ceftriaxone + Sulbactam Sodium
Ceftriaxone + Sulbactam Sodium Pharmacology
Ceftriaxone + Sulbactam Sodium
About Ceftriaxone + Sulbactam SodiumN/AMechanism of Action of Ceftriaxone + Sulbactam SodiumN/APharmacokinets of Ceftriaxone + Sulbactam SodiumN/AOnset of Action for Ceftriaxone + Sulbactam SodiumN/ADuration of Action for Ceftriaxone + Sulbactam SodiumN/AHalf Life of Ceftriaxone + Sulbactam SodiumN/ASide Effects of Ceftriaxone + Sulbactam SodiumN/AContra-indications of Ceftriaxone + Sulbactam SodiumN/ASpecial Precautions while taking Ceftriaxone + Sulbactam SodiumN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Ceftriaxone + Sulbactam SodiumIt is a combination of third generation Cephalosporins Ceftriaxone and Beta-lactamase inhibitor Sulbactam.
1.Urinary tract infections
2.Meningitis
3.Otitismedia
4.Skin & Soft tissue infections
5.Gonorrhoea
6.Syphilis
7.Chancroid
8.Osteomyelitis
9.Nosocomial infections
10.Cholecystitis
11.Surgical prophylaxis
Interactions for Ceftriaxone + Sulbactam SodiumN/ATypical Dosage for Ceftriaxone + Sulbactam SodiumAdults:
Ceftriaxone 250mg to 1000mg + Sulbactum sodium 125mg to 500mg as 2:1 combination Once daily or twice daily depending up on the severity of infections
Schedule of Ceftriaxone + Sulbactam SodiumN/AStorage Requirements for Ceftriaxone + Sulbactam SodiumN/AEffects of Missed Dosage of Ceftriaxone + Sulbactam SodiumN/AEffects of Overdose of Ceftriaxone + Sulbactam SodiumN/ACeftriaxone
About CeftriaxoneThird Generation Cephalosporin antibiotic(Parenteral).Mechanism of Action of CeftriaxoneCeftriaxone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftriaxone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftriaxone.
Pharmacokinets of CeftriaxoneAbsorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: A portion of the drug is metabolized in the body. Excretion:
Excreted through urine & bile. A small portion of drug appears in breast milk.Onset of Action for CeftriaxoneSuddenDuration of Action for Ceftriaxone8 hoursHalf Life of CeftriaxoneN/ASide Effects of Ceftriaxone1.Nausea
2.Vomiting
3.Diarrhoea
4.Superinfection
5.Skin rash
6.Urticaria
7.Pseudomembranous colitis
8.Pain at site of injectionContra-indications of CeftriaxoneHypersensitivity to CeftriaxoneSpecial Precautions while taking Ceftriaxone1.Hepatic impairment
2.Renal impairmentPregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be used
Neonates: Use with caution
Indications for Ceftriaxone1.Meningitis
2.Septicaemia
3.Typhoid
4.UTI
5.Prophylaxis in surgical infections
6.Lower respiratory tract infections
7.Pneumonia
8.Pelvic inflammatory disease
9.STD
10.BacteraemiaInteractions for CeftriaxoneAlcohol: Disulfiram like reaction.
Aminoglycosides & fruesmide: Nephrotoxicity potentiated.
Chloramphenicol: Decreased efficacy of ceftriaxone.Typical Dosage for CeftriaxoneAdults: 1g to 2gm I.M. or I.V. Once daily or two times daily
Maximum adult dose: Up to 4gm/day
Meningitis & Endocarditis: 1 to 2gm I.M. or I.V twice daily; two weeks for meningitis & four weeks for endocarditis
Gonorrhea: 250mg once daily
Children: 50 to 100 mg/kg/day I.M or I.V. two times daily
Maximum child dose: 2g/day
Meningitis & Endocarditis: 50 to 100 mg/kg/day twice daily; two weeks for meningitis & four weeks for endocarditis
Schedule of CeftriaxoneHStorage Requirements for CeftriaxoneN/AEffects of Missed Dosage of CeftriaxoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CeftriaxoneSymptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment is supportive.Sulbactam Sodium
About Sulbactam SodiumAn irreversible ?-lactamase inhibitor, To increase the antibacterial activity of penicillins and cephalosporins against ?-lactamase?producing organisms.Mechanism of Action of Sulbactam SodiumSulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Amoxycillin.
It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.
Pharmacokinets of Sulbactam SodiumN/AOnset of Action for Sulbactam SodiumN/ADuration of Action for Sulbactam SodiumN/AHalf Life of Sulbactam SodiumN/ASide Effects of Sulbactam Sodium1.Injection site reactions
2.Anaphylaxis
3.Diarrhoea
4.Rash
5.Blood dyscrasias
6.Elevated liver enzymes
Contra-indications of Sulbactam SodiumHypersensitivity to SulbactamSpecial Precautions while taking Sulbactam SodiumPatient hypersensitive to CephalosporinPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Sulbactam Sodium1.Skin infections
2.Intra abdominal infectionS
3.Gynecologic infections
Interactions for Sulbactam SodiumN/ATypical Dosage for Sulbactam SodiumAdults:
IM or IV: 1.5 - 3g every 6 hours; dose is depending on creatinine clearance
Schedule of Sulbactam SodiumN/AStorage Requirements for Sulbactam SodiumN/AEffects of Missed Dosage of Sulbactam SodiumN/AEffects of Overdose of Sulbactam SodiumN/AHome Delivery for Ceftriaxone + Sulbactam Sodium in Your City
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