Cefoperazone Sodium + Sulbactam Sodium Pharmacology

Cefoperazone Sodium + Sulbactam Sodium

About Cefoperazone Sodium + Sulbactam Sodium
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Mechanism of Action of Cefoperazone Sodium + Sulbactam Sodium
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Pharmacokinets of Cefoperazone Sodium + Sulbactam Sodium
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Onset of Action for Cefoperazone Sodium + Sulbactam Sodium
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Duration of Action for Cefoperazone Sodium + Sulbactam Sodium
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Half Life of Cefoperazone Sodium + Sulbactam Sodium
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Side Effects of Cefoperazone Sodium + Sulbactam Sodium
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Contra-indications of Cefoperazone Sodium + Sulbactam Sodium
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Special Precautions while taking Cefoperazone Sodium + Sulbactam Sodium
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Pregnancy Related Information
Use with caution
Old Age Related Information
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Breast Feeding Related Information
Use with caution
Children Related Information
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Indications for Cefoperazone Sodium + Sulbactam Sodium
It is a combination of third generation Cephalosporins Cefperazone sodium and Beta-lactamase inhibitor Sulbactam.
1.Pharyngitis
2.Tonsillitis
3.Pneumonia
4.Bronchitis
5.Other respiratory tract infections
6.Septicemia
7.Meningitis
8.Urinogenital tract infections
9.Bone & Joint infections
10.Gonorrhea
11.Endometritis
12.Skin & Soft tissue infections
13.Pelvic inflammatory diseases
14.Intra abdominal infections
Interactions for Cefoperazone Sodium + Sulbactam Sodium
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Typical Dosage for Cefoperazone Sodium + Sulbactam Sodium
Adults:
1 to 2 gm I.M. or I.V. twice daily
In severe infections:
3 to 4 gm I.M. or I.V. thrice daily
Maximum adult dose: 8gm/day.
Children:
40 to 80 mg / kg / day two times daily to four times daily
Maximum child dose: 160 mg / kg / day
Schedule of Cefoperazone Sodium + Sulbactam Sodium
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Storage Requirements for Cefoperazone Sodium + Sulbactam Sodium
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Effects of Missed Dosage of Cefoperazone Sodium + Sulbactam Sodium
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Effects of Overdose of Cefoperazone Sodium + Sulbactam Sodium
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Cefoperazone Sodium

About Cefoperazone Sodium
A third generation cephalosporin antibiotic, Parenteral antibiotic.
Mechanism of Action of Cefoperazone Sodium
Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis
Pharmacokinets of Cefoperazone Sodium
Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not significantly metabolized inside the body. Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

Onset of Action for Cefoperazone Sodium
Sudden
Duration of Action for Cefoperazone Sodium
12 hours
Half Life of Cefoperazone Sodium
2 hours
Side Effects of Cefoperazone Sodium
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestation
3.Super infection
4.Pseudo membranous colitis
5.Nausea
6.Vomiting
7.Diarrhea
8.Elevated liver enzymes
9.Neutropenia
10.Hypoprothrombinemia
Contra-indications of Cefoperazone Sodium
1.Hypersensitivity to cephalosporins
2.Pseudo membranous colitis
Special Precautions while taking Cefoperazone Sodium
1.Renal impairment
2.Hepatic impairment
3 Patient allergic to penicillins
4.Neuromuscular disorders
5.Along with other nephrotoxic drugs
Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
Neonates: contraindicated
Indications for Cefoperazone Sodium
1.Meningitis
2.Biliary infections
3.Septicemia
4.Infections in immunocompromised patients
5.Urinary tract &genital tract infections
6.Surgical prophylaxis
7.Skin & soft tissue infections
8.Bone & Joint infections
9.Gonorrhea,
10.Peritonitis.
Interactions for Cefoperazone Sodium
Alcohol: Disulfiram like reaction upto 72 hours after cefoperazone intake.
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.
Oral anticoagulants: Hypothrombinemic effect potentiated, bleeding complications may occur.
Bacteriostatic agents like Chloramphenicol: Decreases efficacy of Cefoperazone sodium.
Probenecid: Slows tubular excretion and this enhances efficacy.
Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefoperazone Sodium.
Lab. Test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb?s Test: False positive.
Urinary 17-Ketosteroid values: Falsely elevated values.

Typical Dosage for Cefoperazone Sodium
Adults: 1g to 2gm I.M. or I.V. two times daily to three times daily.
In severe infections: 12gm/day in two to four divided doses
Children: 50 to 200 mg/kg/day I.M or I.V. two times daily
In meningitis child dosage: Up to 300mg/kg/day
Maximum adult dose: Up to 12gm/day
Maximum child dose: 300mg/kg/day

Schedule of Cefoperazone Sodium
H
Storage Requirements for Cefoperazone Sodium
Store in a refrigerator & away from light.
Effects of Missed Dosage of Cefoperazone Sodium
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefoperazone Sodium
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Hypoprothrombinemia may also occur. Treatment includes removal of drug from the body by dialysis, administration of vitamin K or blood products & supportive measures

Sulbactam Sodium

About Sulbactam Sodium
An irreversible ?-lactamase inhibitor, To increase the antibacterial activity of penicillins and cephalosporins against ?-lactamase?producing organisms.
Mechanism of Action of Sulbactam Sodium
Sulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Amoxycillin.
It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.

Pharmacokinets of Sulbactam Sodium
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Onset of Action for Sulbactam Sodium
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Duration of Action for Sulbactam Sodium
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Half Life of Sulbactam Sodium
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Side Effects of Sulbactam Sodium
1.Injection site reactions
2.Anaphylaxis
3.Diarrhoea
4.Rash
5.Blood dyscrasias
6.Elevated liver enzymes
Contra-indications of Sulbactam Sodium
Hypersensitivity to Sulbactam
Special Precautions while taking Sulbactam Sodium
Patient hypersensitive to Cephalosporin
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
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Indications for Sulbactam Sodium
1.Skin infections
2.Intra abdominal infectionS
3.Gynecologic infections
Interactions for Sulbactam Sodium
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Typical Dosage for Sulbactam Sodium
Adults:
IM or IV: 1.5 - 3g every 6 hours; dose is depending on creatinine clearance
Schedule of Sulbactam Sodium
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Storage Requirements for Sulbactam Sodium
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Effects of Missed Dosage of Sulbactam Sodium
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Effects of Overdose of Sulbactam Sodium
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