Cefixime Pharmacology


About Cefixime
Third Generation Cephalosporin Oral antibiotic
Mechanism of Action of Cefixime
Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.
Pharmacokinets of Cefixime
Absorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urine
Onset of Action for Cefixime
Within one hour
Duration of Action for Cefixime
18 hours
Half Life of Cefixime
3 hour
Side Effects of Cefixime
1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
11. Headache
12. Dizziness
Contra-indications of Cefixime
1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime
1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Above 6 months: may be used
Neonates: contraindicated
Indications for Cefixime
5.Urinary tract infections
7.Infections caused by susceptible organisms.
Interactions for Cefixime
Probenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.
Typical Dosage for Cefixime
Adults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of Cefixime
Storage Requirements for Cefixime
Effects of Missed Dosage of Cefixime
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefixime
Adopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis

Home Delivery for Cefixime in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefixime.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefixime and other medicines and health products. Home delivery services for cefixime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefixime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefixime before they complete the sale. You can get this information while placing the order for cefixime with the pharmacy.

Cefixime is a generic medicine name and there are several brands available for it. Some of the brands for cefixime might be better known than cefixime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefixime in stock, you can ask for one of the branded alternatives for cefixime.