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- Pharmacology For Ceftriaxone + Tazobactam
Ceftriaxone + Tazobactam Pharmacology
Ceftriaxone + Tazobactam
About Ceftriaxone + TazobactamN/AMechanism of Action of Ceftriaxone + TazobactamN/APharmacokinets of Ceftriaxone + TazobactamN/AOnset of Action for Ceftriaxone + TazobactamN/ADuration of Action for Ceftriaxone + TazobactamN/AHalf Life of Ceftriaxone + TazobactamN/ASide Effects of Ceftriaxone + TazobactamN/AContra-indications of Ceftriaxone + TazobactamN/ASpecial Precautions while taking Ceftriaxone + TazobactamN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Ceftriaxone + TazobactamIt is a combination of third generation Cephalosporins Ceftriaxone and Beta-lactamase inhibitor Tazobactam. It enhances the activity of beta lactam antibacterials against beta lactamase producing bacteria.
1.Pneumonia
2.Lower respiratory tract infection
Interactions for Ceftriaxone + TazobactamN/ATypical Dosage for Ceftriaxone + TazobactamAdult:1000 mg of Ceftriaxone + 125 mg mg of Tazobactam / 500 mg of Ceftriaxone + 62.5 mg of Tazobactam / 250 mg of Ceftriaxone + 31.25 mg of Tazobactam to be given once a day depending upon the severity of the infection. Maximum daily dose: 4 g
Children: 50-75 mg / kg every 12 hours. Maximum daily dose: 2g.
Schedule of Ceftriaxone + TazobactamN/AStorage Requirements for Ceftriaxone + TazobactamN/AEffects of Missed Dosage of Ceftriaxone + TazobactamN/AEffects of Overdose of Ceftriaxone + TazobactamN/ACeftriaxone
About CeftriaxoneThird Generation Cephalosporin antibiotic(Parenteral).Mechanism of Action of CeftriaxoneCeftriaxone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftriaxone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftriaxone.
Pharmacokinets of CeftriaxoneAbsorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: A portion of the drug is metabolized in the body. Excretion:
Excreted through urine & bile. A small portion of drug appears in breast milk.Onset of Action for CeftriaxoneSuddenDuration of Action for Ceftriaxone8 hoursHalf Life of CeftriaxoneN/ASide Effects of Ceftriaxone1.Nausea
2.Vomiting
3.Diarrhoea
4.Superinfection
5.Skin rash
6.Urticaria
7.Pseudomembranous colitis
8.Pain at site of injectionContra-indications of CeftriaxoneHypersensitivity to CeftriaxoneSpecial Precautions while taking Ceftriaxone1.Hepatic impairment
2.Renal impairmentPregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be used
Neonates: Use with caution
Indications for Ceftriaxone1.Meningitis
2.Septicaemia
3.Typhoid
4.UTI
5.Prophylaxis in surgical infections
6.Lower respiratory tract infections
7.Pneumonia
8.Pelvic inflammatory disease
9.STD
10.BacteraemiaInteractions for CeftriaxoneAlcohol: Disulfiram like reaction.
Aminoglycosides & fruesmide: Nephrotoxicity potentiated.
Chloramphenicol: Decreased efficacy of ceftriaxone.Typical Dosage for CeftriaxoneAdults: 1g to 2gm I.M. or I.V. Once daily or two times daily
Maximum adult dose: Up to 4gm/day
Meningitis & Endocarditis: 1 to 2gm I.M. or I.V twice daily; two weeks for meningitis & four weeks for endocarditis
Gonorrhea: 250mg once daily
Children: 50 to 100 mg/kg/day I.M or I.V. two times daily
Maximum child dose: 2g/day
Meningitis & Endocarditis: 50 to 100 mg/kg/day twice daily; two weeks for meningitis & four weeks for endocarditis
Schedule of CeftriaxoneHStorage Requirements for CeftriaxoneN/AEffects of Missed Dosage of CeftriaxoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CeftriaxoneSymptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment is supportive.Tazobactam
About TazobactamA Penicillanic acid sulfone beta-lactamase inhibitor, penams, To increase the antibacterial activity of penicillins against ?-lactamase?producing organisms.Mechanism of Action of TazobactamTazobactam is a Penicillanic acid sulfone beta lactamase inhibitor.Sulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Piperacillin.Pharmacokinets of TazobactamN/AOnset of Action for TazobactamN/ADuration of Action for TazobactamN/AHalf Life of TazobactamN/ASide Effects of Tazobactam1.Gastrointestinal disturbances
2.Headache
3.Dizziness
4.Insomnia
5.Rash
6.Pain
7.Hypertension
8.Edema
9.Pruritus
10.Agitation
11.Local reactions
Contra-indications of TazobactamHypersensitivity to TazobactamSpecial Precautions while taking Tazobactam1.Renal impairment
2.Cystic fibrosis
3.Haematopoiesis
4.Monitor electrolytes
5.Discontinue if bleeding disorders occur
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Tazobactam1.Skin infections
2.Pneumonia
3.Postpartum endometritis
4.Pelvic inflammatory disease
5.Appendicitis
6.Peritonitis
Interactions for TazobactamN/ATypical Dosage for TazobactamIV Infusion over 30 minutes.
Adults: 3 to 4 grams of Piperacillin, in combination with 0.375 to 0.5 grams of Tazobactam, every 6 - 8 hours for 7 - 10 days.
Schedule of TazobactamN/AStorage Requirements for TazobactamN/AEffects of Missed Dosage of TazobactamN/AEffects of Overdose of TazobactamN/AHome Delivery for Ceftriaxone + Tazobactam in Your City
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