- Medicine India
- Generic Medicines
- C
- Pharmacology For Cefixime + Cloxacillin
Cefixime + Cloxacillin Pharmacology
Cefixime + Cloxacillin
About Cefixime + CloxacillinN/AMechanism of Action of Cefixime + CloxacillinN/APharmacokinets of Cefixime + CloxacillinN/AOnset of Action for Cefixime + CloxacillinN/ADuration of Action for Cefixime + CloxacillinN/AHalf Life of Cefixime + CloxacillinN/ASide Effects of Cefixime + CloxacillinN/AContra-indications of Cefixime + CloxacillinN/ASpecial Precautions while taking Cefixime + CloxacillinN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Cefixime is contraindicated in breast feeding, the combination generic cannot be used in breast feedingChildren Related InformationN/AIndications for Cefixime + CloxacillinIt is a combination of third generation Cephalosporins Cefixime and penicillinase resistant Semisynthetic penicillin Cloxacillin.
1.Tonsillitis
2.Pharyngitis
3.Pneumonia
4.Bronchitis & other respiratory tract infections
5.Skin & soft tissue infections
6.Urinary tract infections
Interactions for Cefixime + CloxacillinN/ATypical Dosage for Cefixime + CloxacillinAdult:1 tablet to be taken 2 times daily.Schedule of Cefixime + CloxacillinN/AStorage Requirements for Cefixime + CloxacillinN/AEffects of Missed Dosage of Cefixime + CloxacillinN/AEffects of Overdose of Cefixime + CloxacillinN/ACefixime
About CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis Cloxacillin
About CloxacillinIt is a Penicillinase resistant Penicillin, Penicillin derived antibiotic.Mechanism of Action of CloxacillinCloxacillin is a bactericidal drug. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. In addition to this it is not degraded by penicillinase enzyme and therefore it can be useful against penicillinase producing bacteria also.Pharmacokinets of CloxacillinAbsorption .It is readily absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through urine and small amount excreted through breast milk.Onset of Action for Cloxacillin30-60 minutesDuration of Action for CloxacillinAbout 6 hoursHalf Life of Cloxacillin30 minutesSide Effects of Cloxacillin1.Anaphylaxis
2.Rash
3.Urticaria
4.Thrombocytopenia
5.Seizure
Contra-indications of CloxacillinHypersensitive to Cloxacillin or other Penicillins.Special Precautions while taking Cloxacillin1.Heart failure
2.Uremia
3.Hypokalemia
4 Bleeding tendencies
5.Meningitis
6.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Cloxacillin1.Urinary tract infections
2.Respiratory tract infections
3.Septicaemia
4.Osteomyelitis
5.Endocarditis
6.Pneumonia
7.Sinusitis
8.Bronchiectasis
Interactions for CloxacillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Atenolol: Bio-availability of atenolol reduced.
Allopurinol: Increases risk of cloxacillin induced skin rash.
Probenecid: Increases blood levels.
Erythromycin & Tetracyclines: Reduce efficacy.
Clavulanic Acid: Synergy.
Food: Interferes with absorptionTypical Dosage for CloxacillinADULT
1 - 2 g daily in four divided dose depending on the severity of infection
CHILDREN
50 - 100 mg/kg/day in four divided dose depending on the severity of infection
Schedule of CloxacillinHStorage Requirements for CloxacillinThe vial should be stored in room temperature away from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of CloxacillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of CloxacillinGive supportive measures and symptomatic treatment. Absorption of drug can be reduced by gastric lavage or induction of emesisHome Delivery for Cefixime + Cloxacillin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefixime + cloxacillin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefixime + cloxacillin and other medicines and health products. Home delivery services for cefixime + cloxacillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cefixime + cloxacillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefixime + cloxacillin before they complete the sale. You can get this information while placing the order for cefixime + cloxacillin with the pharmacy.
Cefixime + Cloxacillin is a generic medicine name and there are several brands available for it. Some of the brands for cefixime + cloxacillin might be better known than cefixime + cloxacillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefixime + cloxacillin in stock, you can ask for one of the branded alternatives for cefixime + cloxacillin.
