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- Pharmacology For Cefdinir + Cefepime
Cefdinir + Cefepime Pharmacology
Cefdinir + CefepimeAbout Cefdinir + CefepimeN/AMechanism of Action of Cefdinir + CefepimeN/APharmacokinets of Cefdinir + CefepimeN/AOnset of Action for Cefdinir + CefepimeN/ADuration of Action for Cefdinir + CefepimeN/AHalf Life of Cefdinir + CefepimeN/ASide Effects of Cefdinir + CefepimeN/AContra-indications of Cefdinir + CefepimeN/ASpecial Precautions while taking Cefdinir + CefepimeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Cefdinir + CefepimeN/AInteractions for Cefdinir + CefepimeN/ATypical Dosage for Cefdinir + CefepimeN/ASchedule of Cefdinir + CefepimeN/AStorage Requirements for Cefdinir + CefepimeN/AEffects of Missed Dosage of Cefdinir + CefepimeN/AEffects of Overdose of Cefdinir + CefepimeN/A
CefdinirAbout CefdinirSemisynthetic (Third Generation ) cephalosporin antibiotic, Oral broad-spectrum antibiotic.Mechanism of Action of CefdinirCefdinir is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefdinir inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like CefdinirPharmacokinets of CefdinirAbsorption: Partially absorbed after oral administration, Distribution: Volume of distribution is greater for children than adults. Metabolism: The drug is not significantly metabolized inside the body. Excretion: Excreted mainly through urine
Onset of Action for CefdinirN/ADuration of Action for CefdinirN/AHalf Life of Cefdinir2 hoursSide Effects of Cefdinir1.Rashes
9.Pseudo membranous colitis
Contra-indications of Cefdinir1.Hypersensitivity to cephalosporins
2.Pseudo membranous colitis
Special Precautions while taking Cefdinir1.Renal impairment
2.Patient allergic to Penicillins
3. Use cautiously along with antacids, anticoagulants, & along with other nephrotoxic drugs
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be used.Breast Feeding Related InformationUse with cautionChildren Related Information(Above 6 months): may be usedIndications for Cefdinir1.Pneumonia
5.Skin & soft tissue infections
Interactions for CefdinirAntacids: Cefdinir rate and extent of absorption is reduced in presence of antacid.
Probenecid: It inhibits renal excretion of cefdinir and may prolong plasma levels by competitively inhibiting renal tubular secretion.
Iron: Concomitant administration of cefdinir with therapeutic iron supplement reduces absorption.
Loop diuretics: Risk of nephrotoxicity may be increased.
Typical Dosage for CefdinirAdults: 0.3g twice daily
Children(above 6 months): 14 mg/kg/day twice daily
Maximum child dose: 600mg/day
Pneumonia, Bronchitis, Sinusitis, Otitismedia, Pharyngitis, Tonsillitis & Skin infections:
0.3gm orally twice daily or 0.6mg once daily up to 10 days
Children above 6months:
7mg/kg twice daily or 14mg/kg once daily up to 10 days
Schedule of CefdinirHStorage Requirements for CefdinirStore in a cool dry place.Protect from heat and light.Keep out of the reach of children.Effects of Missed Dosage of CefdinirTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefdinirSymptoms of over dosage include Nausea, vomiting, diarrhea & some times siezures Treatment includes removal of drug from the body by dialysis & supportive measures
CefepimeAbout CefepimeFourth Generation cephalosporin antibiotic.Mechanism of Action of CefepimeCefepime is a 3rd generation cephalosporin which exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Cefepime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like CefipimePharmacokinets of CefepimeWell absorbed after Parenteral administration, Distribution: widely distributed, Metabolism: It is metabolized inside the body Excretion: Excreted mainly through urineOnset of Action for Cefepime30 minutesDuration of Action for CefepimeN/AHalf Life of CefepimeN/ASide Effects of Cefepime1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
7.Pseudo membranous colitis
10.Elevated liver enzymes
Contra-indications of Cefepime1.Hypersensitivity to cephalosporins or Penicillins
2.Along with other nephrotoxic drugs
Special Precautions while taking Cefepime1.Renal impairment
2.Pseudo membranous colitis
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationContraindicated
Neonates: contraindicatedIndications for Cefepime1.Pneumonia
2.Resistant hospital acquired infections
4.Empiric therapy in febrile neutropenic patients
5.Urinary tract infections
7.Tonsillitis, Pharyngitis etc.
8.Skin & soft tissue infections
Interactions for CefepimeN/ATypical Dosage for CefepimeAdults: 1 to 2 gm I.V. twice daily or thrice daily
Urinary tract infections:500mg to 1gm I.V. or I.M. twice daily for 10 days. In severe cases dose may be increased up to 2gm twice daily for 10 days
Infections in neutropenic patients:6gm/day in 3 divided doses; for 1week
Pneumonia:1 to 2 gm twice daily for 10 days
Intra abdominal infections:2gm twice daily for 10 days
Schedule of CefepimeHStorage Requirements for CefepimeStore in a temperature range of 2 degree to 25 degree C and protect from light.Effects of Missed Dosage of CefepimeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefepimeSymptoms of over dosage include neuromuscular disorders and may precipitate seizures. Treatment includes removal of drug from the body by hemodialysis & supportive measures
Home Delivery for Cefdinir + Cefepime in Your City
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Cefdinir + Cefepime is a generic medicine name and there are several brands available for it. Some of the brands for cefdinir + cefepime might be better known than cefdinir + cefepime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefdinir + cefepime in stock, you can ask for one of the branded alternatives for cefdinir + cefepime.