Cefepime Pharmacology


About Cefepime
Fourth Generation cephalosporin antibiotic.
Mechanism of Action of Cefepime
Cefepime is a 3rd generation cephalosporin which exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Cefepime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefipime
Pharmacokinets of Cefepime
Well absorbed after Parenteral administration, Distribution: widely distributed, Metabolism: It is metabolized inside the body Excretion: Excreted mainly through urine
Onset of Action for Cefepime
30 minutes
Duration of Action for Cefepime
Half Life of Cefepime
Side Effects of Cefepime
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2 Rashes
7.Pseudo membranous colitis
10.Elevated liver enzymes
Contra-indications of Cefepime
1.Hypersensitivity to cephalosporins or Penicillins
2.Along with other nephrotoxic drugs
Special Precautions while taking Cefepime
1.Renal impairment
2.Pseudo membranous colitis
Pregnancy Related Information
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Neonates: contraindicated
Indications for Cefepime
2.Resistant hospital acquired infections
4.Empiric therapy in febrile neutropenic patients
5.Urinary tract infections
7.Tonsillitis, Pharyngitis etc.
8.Skin & soft tissue infections
Interactions for Cefepime
Typical Dosage for Cefepime
Adults: 1 to 2 gm I.V. twice daily or thrice daily
Urinary tract infections:500mg to 1gm I.V. or I.M. twice daily for 10 days. In severe cases dose may be increased up to 2gm twice daily for 10 days
Infections in neutropenic patients:6gm/day in 3 divided doses; for 1week
Pneumonia:1 to 2 gm twice daily for 10 days
Intra abdominal infections:2gm twice daily for 10 days
Schedule of Cefepime
Storage Requirements for Cefepime
Store in a temperature range of 2 degree to 25 degree C and protect from light.
Effects of Missed Dosage of Cefepime
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefepime
Symptoms of over dosage include neuromuscular disorders and may precipitate seizures. Treatment includes removal of drug from the body by hemodialysis & supportive measures

Home Delivery for Cefepime in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefepime.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefepime and other medicines and health products. Home delivery services for cefepime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefepime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefepime before they complete the sale. You can get this information while placing the order for cefepime with the pharmacy.

Cefepime is a generic medicine name and there are several brands available for it. Some of the brands for cefepime might be better known than cefepime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefepime in stock, you can ask for one of the branded alternatives for cefepime.