Dextrose 5% Pharmacology

Dextrose 5%

About Dextrose 5%
Intravenous injection / parenteral nutrient, a solution of Dextrose 5% in Water, Carbohydrate caloric nutritional supplement and fluid replenishment.
Mechanism of Action of Dextrose 5%
Dextrose restores blood glucose levels in hypoglycemia and provides a source of carbohydrate calories after IV injection. It decreases losses of body protein and nitrogen, promotes glycogen deposition, and prevents ketosis. It reverses CNS effects of hypoglycemia by rapidly increasing serum glucose levels.
Dextrose injection undergoes oxidation to carbon dioxide and water. Water is an essential constituent of all body tissues Average normal adult requirement ranges from two to three liters. Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments.
Pharmacokinets of Dextrose 5%
Absorption: It is well absorbed after parenteral administration.
Onset of Action for Dextrose 5%
Duration of Action for Dextrose 5%
Half Life of Dextrose 5%
Side Effects of Dextrose 5%
1.Fluid and electrolyte imbalances (((Hypokalemia and dehydration)))
3.Hyperosmotic syndrome (((mental confusion and loss of consciousness)))
4.Reactive hypoglycemia
5.Infection at the site of injection
6.Venous thrombosis
Contra-indications of Dextrose 5%
1.Hypersensitivity to dextrose solution, corn or corn products
2.Diabetic coma while patient is hyperglycemic
3.Intracranial haemorrhage
4.In the presence of delirium in dehydrated patients.
Special Precautions while taking Dextrose 5%
1.Diabetes mellitus
2.Ischemic stroke
4.Renal impairment
5,Urinary tract obstruction
6.Essential electrolytes, minerals, and vitamins should be supplied if needed
7.Potassium should be added to dextrose solutions administered to fasting patients with good renal function, especially those on digitalis therapy
8. Do not administer D50W if there is any doubt about IV patency.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Dextrose 5%
1. Prevention of: dehydration, excessive tissue protein catabolism, depletion of liver glycogen
2. As vehicle for IV numerous drugs
3. Provide calorie in preoperative and post operative patients, patient with severe hepatic, cardiac or gastric disease
4. Source of water in inadequate water intake and excessive water loses
5. Treatment of ketosis in starvation, diarrhoea, vomiting or high fever
6. Hypernatremia
Interactions for Dextrose 5%
Typical Dosage for Dextrose 5%
ADULT: 1.5 - 3 L/day
Maintenance therapy: 1.5-2 L/day over 8-12 hour
Maximum infusion rate: 0.85mg/kg body weight / hour

Schedule of Dextrose 5%
Storage Requirements for Dextrose 5%
Store the drug at 15 - 30 degree C. Do not freeze.
Effects of Missed Dosage of Dextrose 5%
Effects of Overdose of Dextrose 5%
Give supportive measures and symptomatic treatment.

Home Delivery for Dextrose 5% in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextrose 5%.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextrose 5% and other medicines and health products. Home delivery services for dextrose 5% may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dextrose 5% only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextrose 5% before they complete the sale. You can get this information while placing the order for dextrose 5% with the pharmacy.

Dextrose 5% is a generic medicine name and there are several brands available for it. Some of the brands for dextrose 5% might be better known than dextrose 5% itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextrose 5% in stock, you can ask for one of the branded alternatives for dextrose 5%.