Lomefloxacin Pharmacology

Lomefloxacin

About Lomefloxacin

A second generation fluoroquinolone antibiotic, Antibiotic.

Mechanism of Action of Lomefloxacin

Lomefloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Lomefloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.

Pharmacokinets of Lomefloxacin

Absorption: They are rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism. Excretion: Drug is excreted mainly through urine.

Onset of Action for Lomefloxacin

Within 1 hour.

Duration of Action for Lomefloxacin

16-24 hours.

Half Life of Lomefloxacin

6 - 9 hours

Side Effects of Lomefloxacin

1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Restlessness
6.Dizziness
7.Drowsiness
8.Headache
9.Rash
10.Confusion
11.Insomnia

Contra-indications of Lomefloxacin

Hypersensitivity to Lomefloxacin and other Fluoroquinolones

Special Precautions while taking Lomefloxacin

1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Pseudo membranous colitis
5.Dehydration
6.Avoid exposure to sunlight
7.Caution while driving the vehicle or operating machine or involved in any hazardous activities.

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated.

Children Related Information

Contraindicated
NEONATES: Contraindicated

Indications for Lomefloxacin

1.Urinary tract infection
2.Bronchitis
3.Gonorrhoea
4.Skin and soft tissue infections

Interactions for Lomefloxacin

Antacids (Aluminium/Magnesium hydroxide), Iron salts, Sucralfate, Zinc salts: Decreases absorption of lomefloxacin resulting in reduced serum levels.
Antineoplastic agents: Efficacy of lomefloxacin reduced.
Cimetidine: Interference with elimination of lomefloxacin reduced.
Probenecid: Diminished urinary excretion of lomefloxacin.
Anticoagulants: Effects of anticoagulants enhanced.
Food: Delays the rate of absorption of lomefloxacin.

Typical Dosage for Lomefloxacin

Adults: 400 mg / day at night for 10 - 14 days depending on the severity of the infection

Schedule of Lomefloxacin

Storage Requirements for Lomefloxacin

Store at 15 - 30 degree C in a tightly closed container.

Effects of Missed Dosage of Lomefloxacin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.

Effects of Overdose of Lomefloxacin

Give supportive measures and symptomatic treatment. Induce emesis or gastric lavage has to be done.

Home Delivery for Lomefloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lomefloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lomefloxacin and other medicines and health products. Home delivery services for lomefloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lomefloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lomefloxacin before they complete the sale. You can get this information while placing the order for lomefloxacin with the pharmacy.

Lomefloxacin is a generic medicine name and there are several brands available for it. Some of the brands for lomefloxacin might be better known than lomefloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lomefloxacin in stock, you can ask for one of the branded alternatives for lomefloxacin.