Ofloxacin Pharmacology


About Ofloxacin
A second generation fluoroquinolone(quinolones), Antibiotic.
Mechanism of Action of Ofloxacin
Ofloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Ofloxacin
Absorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for Ofloxacin
With in 0.5 hour
Duration of Action for Ofloxacin
12 - 16 hours
Half Life of Ofloxacin
5 - 8 hours
Side Effects of Ofloxacin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin
1. Hypersensitivity to Ofloxacin and other Fluoroquinolones
Special Precautions while taking Ofloxacin
1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES : Contraindicated

Indications for Ofloxacin
1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. Cervicitis
Interactions for Ofloxacin
Oral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.
Typical Dosage for Ofloxacin
Adults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses

Schedule of Ofloxacin
Storage Requirements for Ofloxacin
Store at 15 - 30 degree C in a tightly closed container.
Effects of Missed Dosage of Ofloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Ofloxacin
Give supportive measures and symptomatic treatment. Gastric lavage has to be done.

Home Delivery for Ofloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ofloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ofloxacin and other medicines and health products. Home delivery services for ofloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ofloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ofloxacin before they complete the sale. You can get this information while placing the order for ofloxacin with the pharmacy.

Ofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for ofloxacin might be better known than ofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ofloxacin in stock, you can ask for one of the branded alternatives for ofloxacin.