Levofloxacin Pharmacology


About Levofloxacin
Third generation fluoroquinolone (or quinolone), A broad spectrum antiinfective.
Mechanism of Action of Levofloxacin
Levofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Levofloxacin
Absorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.
Onset of Action for Levofloxacin
Duration of Action for Levofloxacin
Half Life of Levofloxacin
6 - 8 hour
Side Effects of Levofloxacin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Restlessness
6. Dizziness
7. Drowsiness
8. Arthralgia
9. Rash
10. Confusion
11. Insomnia
12. Anorexia
13. Bad taste
14. Headache
15. Photosensitivity.
Contra-indications of Levofloxacin
Hypersensitivity to Levofloxacin and other Fluoroquinolones
Special Precautions while taking Levofloxacin
1.Hepatic impairment
2.Renal impairment
4.Cerebral arteriosclerosis

Caution while driving the vehicle or operating machine or involved in any hazardous activities. Avoid exposure to sun light

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information

Indications for Levofloxacin
4.Urinary tract infection
5.Traveler`s diarrhoea
6.Skin and soft tissue infections
Interactions for Levofloxacin
Typical Dosage for Levofloxacin
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
Sinusitis, Bronchitis, Pneumonia, Skin and soft tissue infections: 500 mg daily for 1 - 2 week
Urinary tract infection: 250 mg / day for 10 days
Traveler`s diarrhoea: 500 mg / day along with Loperamide
Urethritis: 500 mg orally once daily for 7 days
Schedule of Levofloxacin
Storage Requirements for Levofloxacin
Store at 25 - 30 degree C in a tightly closed container.
Effects of Missed Dosage of Levofloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Levofloxacin
Give supportive measures and symptomatic treatment. Empty the stomach. Maintain appropriate hydration.

Home Delivery for Levofloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levofloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levofloxacin and other medicines and health products. Home delivery services for levofloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levofloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levofloxacin before they complete the sale. You can get this information while placing the order for levofloxacin with the pharmacy.

Levofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for levofloxacin might be better known than levofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levofloxacin in stock, you can ask for one of the branded alternatives for levofloxacin.