Sparfloxacin Pharmacology


About Sparfloxacin
A third generation fluoroquinolone, A synthetic broad-spectrum antibiotic.
Mechanism of Action of Sparfloxacin
Sparfloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Sparfloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Sparfloxacin
Absorption: The drug is absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes hepatic metabolism.
Excretion: Drug is excreted through urine and faeces.
Onset of Action for Sparfloxacin
Duration of Action for Sparfloxacin
Half Life of Sparfloxacin
15 - 20 hour
Side Effects of Sparfloxacin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Seizure
6. Dizziness
7. Headache
8. Pseudomembranous colitis
9. Rash
10. Somnolence
11. Insomnia
12. Photosensitivity
13. Pruritis

Contra-indications of Sparfloxacin
1. Hypersensitivity to Sparfloxacin and other Fluoroquinolones
Special Precautions while taking Sparfloxacin
1. Hepatic impairment
2. Renal impairment
3. Cardiac impairment
4. Epilepsy
5. Concomitant use of anti-arrhythmic drug.
6. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
7. Avoid exposure to sunlight.
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Sparfloxacin
1. Bronchitis
2. Pneumonia
3. Gonococcal urethritis
Interactions for Sparfloxacin
Typical Dosage for Sparfloxacin
Adults: Loading dose: 400 mg / day followed by 200 mg / day for 10 days
Gonococcal urethritis: 200 mg / day as single dose.

Schedule of Sparfloxacin
Storage Requirements for Sparfloxacin
Store at 20- 25 degree C in a tightly closed container.
Effects of Missed Dosage of Sparfloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sparfloxacin
Give supportive measures and symptomatic treatment.

Home Delivery for Sparfloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sparfloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sparfloxacin and other medicines and health products. Home delivery services for sparfloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sparfloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sparfloxacin before they complete the sale. You can get this information while placing the order for sparfloxacin with the pharmacy.

Sparfloxacin is a generic medicine name and there are several brands available for it. Some of the brands for sparfloxacin might be better known than sparfloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sparfloxacin in stock, you can ask for one of the branded alternatives for sparfloxacin.