Gatifloxacin Pharmacology


About Gatifloxacin
Fourth-generation fluoroquinolone, DNA Gyrase Inhibitor,Topoisomerase I Inhibitor, Antibiotic.
Mechanism of Action of Gatifloxacin
Gatifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gatifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis in microorganisms.
Pharmacokinets of Gatifloxacin
Absorption: Gatifloxacin is well absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes limited metabolism. Excretion: Drug is excreted mainly through urine.
Onset of Action for Gatifloxacin
Duration of Action for Gatifloxacin
Half Life of Gatifloxacin
8 hour
Side Effects of Gatifloxacin
4.Abdominal discomfort

Contra-indications of Gatifloxacin
Hypersensitivity to Gatifloxacin and other Fluoroquinolones
Special Precautions while taking Gatifloxacin
1.Hepatic impairment
2.Renal impairment
4.Concomitant use of antiarrhythmic drugs
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
6.Avoid long exposure to sunlight.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: contraindicated
Indications for Gatifloxacin
4.Urinary tract infections
6.Skin and skin structure infections
Interactions for Gatifloxacin
Probenicid : Systemic exposure to gatifloxacin is increased following concomitant administration of gatifloxacin and probenicid.
Ferrous sulphate /Antacid : Systemic exposure is reduced when gatifloxacin is given concomitantly with Ferrous sulphate or with antacids containing aluminium or magnesium salts.
Typical Dosage for Gatifloxacin
Adults: 400 mg once daily for 1 - 2 week
Dose is determined on the basis of severity of the infection and type of infecting organism
Bronchitis: 400 mg once daily for 5 days
Sinusitis: 400 mg once daily for 10 days
Pneumonia: 400 mg once daily for 1 - 2 week
Skin and skin structure infections, Complicated UTI, Pyelonephritis: 400 mg once daily for 7 - 10 days
Uncomplicated UTI: 200 mg / day for 3 days
Gonorrhoea: 400 mg as a single dose.
Schedule of Gatifloxacin
Storage Requirements for Gatifloxacin
Store at room temperature in a tightly closed container.
Effects of Missed Dosage of Gatifloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Gatifloxacin
Give supportive measures and symptomatic treatment.

Home Delivery for Gatifloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gatifloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gatifloxacin and other medicines and health products. Home delivery services for gatifloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gatifloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gatifloxacin before they complete the sale. You can get this information while placing the order for gatifloxacin with the pharmacy.

Gatifloxacin is a generic medicine name and there are several brands available for it. Some of the brands for gatifloxacin might be better known than gatifloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gatifloxacin in stock, you can ask for one of the branded alternatives for gatifloxacin.