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- Pharmacology For Gatifloxacin + Ambroxol
Gatifloxacin + Ambroxol Pharmacology
Gatifloxacin + AmbroxolAbout Gatifloxacin + AmbroxolN/AMechanism of Action of Gatifloxacin + AmbroxolN/APharmacokinets of Gatifloxacin + AmbroxolN/AOnset of Action for Gatifloxacin + AmbroxolN/ADuration of Action for Gatifloxacin + AmbroxolN/AHalf Life of Gatifloxacin + AmbroxolN/ASide Effects of Gatifloxacin + AmbroxolN/AContra-indications of Gatifloxacin + AmbroxolN/ASpecial Precautions while taking Gatifloxacin + AmbroxolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Gatifloxacin + AmbroxolN/AInteractions for Gatifloxacin + AmbroxolN/ATypical Dosage for Gatifloxacin + AmbroxolN/ASchedule of Gatifloxacin + AmbroxolN/AStorage Requirements for Gatifloxacin + AmbroxolN/AEffects of Missed Dosage of Gatifloxacin + AmbroxolN/AEffects of Overdose of Gatifloxacin + AmbroxolN/A
GatifloxacinAbout GatifloxacinFourth-generation fluoroquinolone, DNA Gyrase Inhibitor,Topoisomerase I Inhibitor, Antibiotic.Mechanism of Action of GatifloxacinGatifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gatifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis in microorganisms.Pharmacokinets of GatifloxacinAbsorption: Gatifloxacin is well absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes limited metabolism. Excretion: Drug is excreted mainly through urine.Onset of Action for GatifloxacinN/ADuration of Action for GatifloxacinN/AHalf Life of Gatifloxacin8 hourSide Effects of Gatifloxacin1.Nausea
Contra-indications of GatifloxacinHypersensitivity to Gatifloxacin and other FluoroquinolonesSpecial Precautions while taking Gatifloxacin1.Hepatic impairment
4.Concomitant use of antiarrhythmic drugs
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
6.Avoid long exposure to sunlight.
Pregnancy Related InformationUse with caution
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: contraindicatedIndications for Gatifloxacin1.Pneumonia
4.Urinary tract infections
6.Skin and skin structure infections
Interactions for GatifloxacinProbenicid : Systemic exposure to gatifloxacin is increased following concomitant administration of gatifloxacin and probenicid.
Ferrous sulphate /Antacid : Systemic exposure is reduced when gatifloxacin is given concomitantly with Ferrous sulphate or with antacids containing aluminium or magnesium salts.
Typical Dosage for GatifloxacinAdults: 400 mg once daily for 1 - 2 week
Dose is determined on the basis of severity of the infection and type of infecting organism
Bronchitis: 400 mg once daily for 5 days
Sinusitis: 400 mg once daily for 10 days
Pneumonia: 400 mg once daily for 1 - 2 week
Skin and skin structure infections, Complicated UTI, Pyelonephritis: 400 mg once daily for 7 - 10 days
Uncomplicated UTI: 200 mg / day for 3 days
Gonorrhoea: 400 mg as a single dose.
Schedule of GatifloxacinHStorage Requirements for GatifloxacinStore at room temperature in a tightly closed container.Effects of Missed Dosage of GatifloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of GatifloxacinGive supportive measures and symptomatic treatment.
AmbroxolAbout AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
3.Gastric and duodenal ulcer
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.
Home Delivery for Gatifloxacin + Ambroxol in Your City
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Gatifloxacin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for gatifloxacin + ambroxol might be better known than gatifloxacin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gatifloxacin + ambroxol in stock, you can ask for one of the branded alternatives for gatifloxacin + ambroxol.